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Ann Med Interne (Paris) ; 136(4): 311-5, 1985.
Article in French | MEDLINE | ID: mdl-4037586

ABSTRACT

Four cases of amiodarone-induced restrictive, hypoxaemic lung disease are described. The cumulative dosages of amiodarone were relatively low (30 to 100 g). Alveolar lavage studies showed a lymphocytosis and study of the lymphocytic sub-populations showed an increase in the OKT8 group, and an inversion of the OKT4/OKT8 ratio. The outcome was favourable on withdrawal of amiodarone and steroid therapy. The immunological origin of this form of lung disease was confirmed. Two patients had renal failure; in the first case, hypercalcaemia, hyperphosphoremia and renal calcification were observed. The second patient had endo- and extracapillary glomerulonephritis with C3 deposits and circulating immune complexes. Renal failure regressed in both cases on withdrawal of amiodarone and with steroid therapy.


Subject(s)
Amiodarone/adverse effects , Benzofurans/adverse effects , Drug Hypersensitivity/complications , Kidney Diseases/chemically induced , Pulmonary Alveoli/pathology , Pulmonary Fibrosis/chemically induced , Acute Kidney Injury/chemically induced , Aged , Female , Humans , Lymphocytes/classification , Male , Middle Aged , Pulmonary Fibrosis/immunology , Pulmonary Fibrosis/pathology , Therapeutic Irrigation
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