ABSTRACT
PURPOSE: Oesophageal squamous papilloma (OSP) is a rare epithelial lesion with an unclear aetiology, found incidentally in upper gastrointestinal endoscopy (UGE). We evaluate the epidemiology, general features and endoscopic and histological characteristics of OSP in children in a single centre. METHODS: We conducted a retrospective search of 3568 medical records of children under 18 years old who underwent UGE between 2004 and 2022, at Hospital Metropolitano de Quito, Ecuador. We described the general features of 15 patients diagnosed with OSP. Histopathology reports were analysed, including a chromogenic in situ hybridisation (CISH) for human papillomavirus (HPV) 6/11. RESULTS: OSP was diagnosed in 15 patients between 10 and 16 years of age, with an estimated prevalence of 0.4%. The gender ratio male to female was 1:1.1. Most patients (n=14) underwent UGE due to abdominal pain. Lesions were found predominantly in the upper and lower part of the oesophagus; 12 patients had isolated lesions, and none of the lesions tested positive for HPV on CISH 6/11 analysis. Additionally, Helicobacter pylori and eosinophilic oesophagitis (EoE) were diagnosed in one patient each. CONCLUSION: Our study describes the clinical features of paediatric OSP in a single centre. The prevalence was similar to that in the adult population but higher than in other paediatric populations, and none of our patients had HPV.
Subject(s)
Carcinoma, Squamous Cell , Eosinophilic Esophagitis , Esophageal Neoplasms , Papilloma , Papillomavirus Infections , Adult , Humans , Male , Child , Female , Adolescent , Retrospective Studies , Papillomavirus Infections/diagnosis , Papillomavirus Infections/epidemiology , Eosinophilic Esophagitis/diagnosis , Eosinophilic Esophagitis/epidemiology , Eosinophilic Esophagitis/pathology , Esophageal Neoplasms/diagnosis , Esophageal Neoplasms/epidemiologyABSTRACT
A 1-month-old male, exclusively breastfed, presented with 24 h of bloody stools, vomiting, metabolic acidosis, and pneumatosis intestinalis. The patient was initially treated for necrotizing enterocolitis (NEC). However, after suspecting food protein-induced enterocolitis syndrome (FPIES), oral feeding was resumed using an exclusive elemental formula, and the biochemical and radiological findings were resolved.
