[Short-term Lycopersicum esculentum consumption may increase plasma high density lipoproteins and decrease oxidative stress]. / El consumo de Lycopersicum esculentum podría aumentar lipoproteínas de alta densidad (HDL) y disminuir el estrés oxidativo a corto plazo.

BACKGROUND: Tomato has a high antioxidant capacity due to its high content of vitamin C, vitamin E and lycopene that is a powerful free radical scavenger. However, the effects of tomato on plasma lipoproteins is not well known, and there is little evidence about the relationship between tomato consumption and oxidative state changes in humans. AIM: To assess in vivo the effects of dietary supplementation with pure concentrated tomato juice on short term changes in oxidative state and plasma lipoproteins in healthy volunteers. SUBJECTS AND METHODS: Seventeen healthy volunteers were studied. They received a supplement of pure tomato juice during 7 days. At baseline, at the end of the supplementarion period and eight days after the end of the supplementation, a blood sample was drawn to measure total antioxidant capacity (TRAP), enzymatic antioxidants (catalase and superoxide dismutase), non-enzimatic antioxidants (lycopene and a-tocopherol) and plasma lipoproteins. RESULTS: Lycopene level increased early and significantly in comparison with basal levels (48%; p < 0.05). TRAP, catalase and superoxide dismutase did not change significantly. HDL cholesterol increased significantly in 5.6+/-4.3 mg/dL (p < 0.002) on the second sampling period, improving the ratio cholesterol/HDL. It returned to baseline in the third period. CONCLUSIONS: Dietary supplementation of concentrated tomato juice significantly increases lycopene levels and HDL cholesterol. Non significant changes observed in TRAP, catalase and superoxide dismutase were observed during the supplementation period.

El consumo de Lycopersicum esculentum podría aumentar lipoproteínas de alta densidad (HDL) y disminuir el estrés oxidativo a corto plazo / Short-term Lycopersicum esculentum consumption may increase plasma high density lipoproteins and decrease oxidative stress

Background: Tomato has a high antioxidant capacity due to its high content of vitamin C, vitamin E and lycopene that is a powerful free radical scavenger. However, the effects of tomato on plasma lipoproteins is not well known, and there is little evidence about the relationship between tomato consumption and oxidative state changes in humans. Aim: To assess in vivo the effects of dietary supplementation with pure concentrated tomato juice on short term changes in oxidative state and plasma lipoproteins in healthy volunteers. Subjects and methods: Seventeen healthy volunteers were studied. They received a supplement of pure tomato juice during 7 days. At baseline, at the end of the supplementarion period and eight days after the end of the supplementation, a blood sample was drawn to measure total antioxidant capacity (TRAP), enzymatic antioxidants (catalase and superoxide dismutase), non-enzimatic antioxidants (lycopene and a-tocopherol) and plasma lipoproteins. Results: Lycopene level increased early and significantly in comparison with basal levels (48%; p <0.05). TRAP, catalase and superoxide dismutase did not change significantly. HDL cholesterol increased significantly in 5.6±4.3 mg/dL (p <0.002) on the second sampling period, improving the ratio cholesterol/HDL. It returned to baseline in the third period. Conclusions: Dietary supplementation of concentrated tomato juice significantly increases lycopene levels and HDL cholesterol. Non significant changes observed in TRAP, catalase and superoxide dismutase were observed during the supplementation period.

Secuelas de la trombosis venosa profunda de las extremidades inferiores luego de un tratamiento anticoagulante controlado / Sequels of deep venous thrombosis of the lower limbs after a controlled anticoagulant therapy

Objetivo: Con el fin de evaluar la eficacia de la anticoagulación "clásica" en prevenir las secuelas en el sistema venoso profundo luego de un primer episodio de trombosis venosa profunda (TVP), se efectuó un año después un control clínico y con ecodoppler color, a pacientes que habían sufrido una TVP tratada con Heparina y anticoagulantes orales. Material y método: Sesenta y dos pacientes (47 mujeres y 15 varones, promedio de edad 53,5 años) fueron ingresados en el Hospital Dr. Eduardo Pereira de Valparaíso durante el episodio inicial de trombosis confirmadas con ecodoppler color y tratados con heparina sódica o de bajo peso molecular. Luego se les sometió a un prolongado tiempo de tratamiento anticoagulante oral (TACO) controlado. Fueron clasificados en trombosis distales 13 pacientes (21 por ciento), fémoro-poplíteas 21 pacientes (33,9 por ciento) e ilio-fémoro-poplíteas 28 pacientes (45,2 por ciento). Se constató el tiempo transcurrido entre el comienzo de los síntomas y el inicio del tratamiento con heparina con un promedio de 9,8 días. Se evaluó también el grado de eficacia anticoagulante del TACO según el número de controles con un International Nornalized Ratio (INR) eficaz sobre 2,0. Se encontró un buen TACO en 40 pacientes (64,5 por ciento) (INR eficaz sobre el 75 por ciento de los controles), un TACO regular en 12 pacientes (19,4 por ciento) (INR eficaz menor del 75 por ciento, pero mayor del 50 por ciento en los controles) y un TACO malo en 10 pacientes (16,1 por ciento) (INR eficaz en menos de la mitad de los controles). Resultados: Entre 9 meses y un año después se efectuó un control clínico y con ecodoppler color a todos los pacientes. La evaluación clínica se realizó según la clasificación de Casanueva del Síndrome Post-trombótico. Veinticuatro pacientes (38,7 por ciento) de los pacientes (38,7 por ciento) de los pacientes se encontraban asintomáticos (grado 0), 30 (48,4 por ciento) presentaba sólo edema (grados 1 y 2), 4 (6,5 por ciento) presentaban edema y várices secundarias (grado 3) y 4 pacientes (6,5 por ciento) presentaban además lipodermatoesclerosis o úlceras de la pierna (grado 4). Las secuelas evaluadas con ecodoppler color fueron la insuficiencia valvular, la obliteración venosa y otras lesiones, como fibrosis parietales, bandas fibrosas intraluminales y estenosis con flujo venoso parcial...