1.
J Org Chem
; 84(24): 15997-16002, 2019 12 20.
Article
in English
| MEDLINE
| ID: mdl-31746213
ABSTRACT
Enantioselective synthesis of ampelomin B and epi-ampelomin B, D, and E was accomplished starting from toluene, through a chemoenzymatic sequence, in which stereoselective hydrogenation, Mitsunobu reaction, and regio- and stereoselective nucleophilic opening of an epoxide were used as the main transformations. Structural revision and absolute configuration of the natural compounds were carried out.