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1.
Sci Rep ; 9(1): 19000, 2019 12 12.
Article in English | MEDLINE | ID: mdl-31831864

ABSTRACT

We propose a model to generate electrocardiogram signals based on a discretized reaction-diffusion system to produce a set of three nonlinear oscillators that simulate the main pacemakers in the heart. The model reproduces electrocardiograms from healthy hearts and from patients suffering various well-known rhythm disorders. In particular, it is shown that under ventricular fibrillation, the electrocardiogram signal is chaotic and the transition from sinus rhythm to chaos is consistent with the Ruelle-Takens-Newhouse route to chaos, as experimental studies indicate. The proposed model constitutes a useful tool for research, medical education, and clinical testing purposes. An electronic device based on the model was built for these purposes.


Subject(s)
Electrocardiography , Models, Cardiovascular , Signal Processing, Computer-Assisted , Arrhythmias, Cardiac/diagnostic imaging , Computer Simulation , Diffusion , Nonlinear Dynamics , Numerical Analysis, Computer-Assisted , Time Factors , Ventricular Fibrillation/diagnostic imaging
2.
Comput Biol Med ; 104: 87-96, 2019 01.
Article in English | MEDLINE | ID: mdl-30453221

ABSTRACT

We propose a simple model of the electrical activity of the heart that reproduces realistic healthy electrocardiogram (ECG) signals. The model consists of two RLC linear oscillators periodically kicked by impulses of the main pacemaker with the frequency rate of a real heart. In the proposed model, one oscillator represents the atria, another represents the ventricles, and an electrical cardiac conduction system is included using a coupling capacitor, which can be either unidirectional or bidirectional. The network of the two capacitively coupled oscillators is periodically kicked by the main pacemaker to introduce the periodic forcing of limit cycles into the system; a time delay is introduced to represent the electrical transport delay from atria to ventricles. In this manner, healthy synthetic ECG signals are obtained by combining the signals of the currents of the oscillators. We show that an analytical solution of the model can be obtained when a single impulse is applied. From this, by the superposition principle, a solution with an impulse train is obtained. Note that analytical treatment is a feature not available in current cardiac oscillator models.


Subject(s)
Action Potentials , Biological Clocks , Electrocardiography , Heart Conduction System/physiopathology , Models, Cardiovascular , Humans
3.
Forensic Sci Int ; 281: 134-140, 2017 Dec.
Article in English | MEDLINE | ID: mdl-29128653

ABSTRACT

This paper presents a forensic methodology that determines, from among a set of recording places, the probable place where allegedly a disputed digital audio recording was made. The methodology considers that digital audio recordings are noisy signals that have two involved noise components. One component is the multiplicative noise, which is an internal feature on the audio recording that is related to the recording device. The other component is the additive noise, which is an external feature on the audio recording that can be related to the recording place. Therefore, the proposed methodology estimates a likelihood rate that helps to decide which recording place is more plausible to be associated with a disputed audio recording. This likelihood rate is defined as the probability of a finding, supposing that a specific proposition is true, divided by the probability of a finding if an alternative proposition is true. Such probabilities are calculated by performing a statistical comparison through the Kullback-Leibler divergence [1], between the probability distribution function of the additive noise associated to the disputed recording and the probability distribution function of the additive noises associated to a set of audio recordings made on the possible recording places. Then, in order to determine the recording place, the analyst requires a list of possible places where the recording could have been carried out; in these places some reference recordings will be made. In this work, the additive noise is estimated by the Geometric Approach to Spectral Subtraction (GA-SS) filter [2], applied to the noisy audio recording.

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