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Carbohydr Res ; 543: 109216, 2024 Sep.
Article in English | MEDLINE | ID: mdl-39043084

ABSTRACT

In this study, a series of hydrogels were synthesized from chitosan(s) that was crosslinking with glutaraldehyde at different concentrations. Ascorbic acid in an acidic medium was used to facilitate non-covalent interactions. The chitosan(s) was obtained from shrimp cytoskeleton; while ascorbic acid was extracted from xoconostle juice. The hydrogel reaction was monitored by UV-vis spectroscopy (550 nm) to determine the reaction kinetics and reaction order at 60 °C. The hydrogels structures were characterized by NMR, FT-IR, HR-MS and SEM, while the degree of cross-linking was examined with TGA-DA. The extracellular matrices were obtained as stable hydrogels where reached maximum crosslinking was of 7 %, independent of glutaraldehyde quantity added. The rheological properties showed a behavior of weak gels and a dependence of crosslinking agent concentration on strength at different temperatures. The cytotoxicity assay showed that the gels had no adverse effects on cellular growth for all concentrations of glutaraldehyde.


Subject(s)
Biocompatible Materials , Chitosan , Hydrogels , Tissue Engineering , Hydrogels/chemistry , Hydrogels/chemical synthesis , Biocompatible Materials/chemistry , Biocompatible Materials/chemical synthesis , Biocompatible Materials/pharmacology , Chitosan/chemistry , Chitosan/pharmacology , Chitosan/chemical synthesis , Animals , Glutaral/chemistry , Rheology , Cross-Linking Reagents/chemistry
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