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1.
Genes (Basel) ; 13(9)2022 08 25.
Article in English | MEDLINE | ID: mdl-36140693

ABSTRACT

We aimed to evaluate the effect of selected polymorphisms of the ACTN3, ACE, HIF1A and PPARA genes on the immediate supercompensation training effect of elite Slovak endurance runners and football players compared with a sedentary control group. Adaptation effect levels were evaluated by 10 s continuous vertical jump test parameters measured by Optojump. Genetic polymorphisms were determined by PCR and Sanger sequencing. We found significant differences in the effect of PPARA genotypes in the experimental group. C allele genotypes represented an advantage in immediate supercompensation (p < 0.05). We observed a significant combined effect of multiple genes on immediate supercompensation (p < 0.05): the RR genotype of the ACTN3 gene, the ID genotype of the ACE gene, the Pro/Pro genotype of HIF1A, and the GC and GG genotypes of PPARA genes. In the control group, we found a significant effect (p < 0.05) on immediate supercompensation of the II genotype of the ACE gene and the Pro/Ser genotype of the HIF1A gene. We found significant differences in genotype frequency of ACE (p < 0.01) and PPARA (p < 0.001) genes. We confirmed that individual genetic polymorphisms of ACTN3, ACE, HIF1A and PPARA genes have a different effect on the level of immediate supercompensation of the lower limbs depending on the training adaptation of the probands and the combination of genotypes.


Subject(s)
Actinin , Football , Actinin/genetics , PPAR alpha/genetics , Peptidyl-Dipeptidase A/genetics , Polymorphism, Genetic , Slovakia
2.
Phys Rev Lett ; 120(20): 201604, 2018 May 18.
Article in English | MEDLINE | ID: mdl-29864367

ABSTRACT

Holographic theories with classical gravity duals are maximally chaotic; i.e., they saturate the universal bound on the rate of growth of chaos [J. Maldacena, S. H. Shenker, and D. Stanford, J. High Energy Phys. 08 (2016) 106JHEPFG1029-847910.1007/JHEP08(2016)106]. It is interesting to ask whether this property is true only for leading large N correlators or if it can show up elsewhere. In this Letter, we consider the simplest setup to tackle this question: a Brownian particle coupled to a thermal ensemble. We find that the four-point out-of-time-order correlator that diagnoses chaos initially grows at an exponential rate that saturates the chaos bound, i.e., with a Lyapunov exponent λ_{L}=2π/ß. However, the scrambling time is parametrically smaller than for plasma excitations, t_{*}∼ßlogsqrt[λ] instead of t_{*}∼ßlogN^{2}. Our result shows that, at least in certain cases, maximal chaos can be attained in the probe sector without the explicit need of gravitational degrees of freedom.

3.
Phys Rev Lett ; 112(7): 071602, 2014 Feb 21.
Article in English | MEDLINE | ID: mdl-24579588

ABSTRACT

We discuss the dc conductivity of holographic theories with translational invariance broken by a background lattice. We show that the presence of the lattice induces an effective mass for the graviton via a gravitational version of the Higgs mechanism. This allows us to obtain, at leading order in the lattice strength, an analytic expression for the dc conductivity in terms of the size of the lattice at the horizon. In locally critical theories this leads to a power law resistivity that is in agreement with an earlier field theory analysis of Hartnoll and Hofman.

4.
Philos Trans A Math Phys Eng Sci ; 369(1941): 1640-69, 2011 Apr 28.
Article in English | MEDLINE | ID: mdl-21422019

ABSTRACT

Techniques arising from string theory can be used to study assemblies of strongly interacting fermions. Via this 'holographic duality', various strongly coupled many-body systems are solved using an auxiliary theory of gravity. Simple holographic realizations of finite density exhibit single-particle spectral functions with sharp Fermi surfaces, of a form distinct from those of the Landau theory. The self-energy is given by a correlation function in an infrared (IR) fixed-point theory that is represented by a two-dimensional anti de Sitter space (AdS(2)) region in the dual gravitational description. Here, we describe in detail the gravity calculation of this IR correlation function.

5.
Science ; 329(5995): 1043-7, 2010 Aug 27.
Article in English | MEDLINE | ID: mdl-20688983

ABSTRACT

Fermi liquid theory explains the thermodynamic and transport properties of most metals. The so-called non-Fermi liquids deviate from these expectations and include exotic systems such as the strange metal phase of cuprate superconductors and heavy fermion materials near a quantum phase transition. We used the anti-de-Sitter/conformal field theory correspondence to identify a class of non-Fermi liquids; their low-energy behavior is found to be governed by a nontrivial infrared fixed point, which exhibits nonanalytic scaling behavior only in the time direction. For some representatives of this class, the resistivity has a linear temperature dependence, as is the case for strange metals.

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