ABSTRACT
This single-dose study demonstrate the analgesic efficacy of zomepirac sodium in post-operative pain. Total Pain Relief afforded by zomepirac sodium 100 mg was significantly better than mefenamic acid 500 mg. Pain Intensity Difference scores likewise showed that the zomepirac sodium 100 mg was significantly better than zomepirac sodium 50 mg. zomepirac sodium 25 mg and placebo treatmentsThese results further support previous reports that zomepirac sodium is a safe and effective analgesic in the treatment of moderate to severe post-operative pain. (Summary)
ABSTRACT
1. The actions of emetine on the heart and pulmonary circulation were studied in a total of 45 anesthetized dogs2. Emetine was shown to lower both systemic and pulmonic blood pressures when injected intravenously in doses from 0.05 to 7.5 mg./Kg. The mechanism by which this hypotension was brought appeared to be solely by cardiac depression. No significant direct vasodilating action was demonstrated3. The applicability and dangers of emetine as an antihemoptic agent were discussed. (Summary)
ABSTRACT
1. The antispasmodic effect of some official drugs were studied in dogs using balloons appropriately placed on the intact enteric tract. Intestinal contractions were kymographically recorded2. Comparable doses (threshold relaxing doses) of the pharmacologic agents were determined and tested under uniform experimental conditions3. Tested against spontaneous, Barium-stimulated and Pilocarpine-stimulated intestinal contractions, Methantheline and Atropine were shown to be the most potent agents. Aminophylline, Papaverine and Glyceryl trinitrate follow in the order named. This comparison is on the basis of the average duration of their respective inhibiting effect on the intestine4. The experimental findings in this method of study appear to be in close agreement with clinical observations5. It is postulated that in certain gastro-intestinal conditions characterized by hyperperistalsis, spasm and pain, these antispasmodics will prove clinically effective, if wisely administered. (Summary and Conclusions)
ABSTRACT
Analysis of the results of the Dynamic Exercise and Post-Exercise ECG tests given to 206 young normal subjects and to 302 patients with probable, presumptive, or definite evidence of coronary heart diseases revealed the following1. Using ischemic ST depression of at least 1.0 mm as the sole criterion for a positive test, the Dynamic Exercise ECG did not give more "false positive" results than the Post-Erxercise ECG in the known normal subjects while in the "coronary" patients, the Dynamic Exercise ECG detected almost five times as many coronary insufficiencies as the Post-Exercise ECG2. Junctional ST depressions of 1.5 mm or more in the Post-Exercise ECG were found to be residuals of previous ischemic ST depressions in about 60 per cent of cases, and should therefore be regarded as suspicious indications of coronary insufficiency whenever the Dynamic Exercise ECG is unavailable3. The significance of and the possibility of the inclusion of "prolonged" QTc interval as a criterion to increase the sensiitivity of the Exercise Test was discussed4. Despite the demonstrated superiority of the Dynamic Eercise ECG it had a few limitations which the post exercise ECG could compensate. In view of this, it was recommended that the two exercise ECG tests be combined for which the name "Combined Dynamic-Post-exercise ECG Test" was proposed."(Summary and Conclusions)
ABSTRACT
No doubt physicians will continue to argue about the usefulness of chemoprophylaxis in the above conditions. However, all controlled trials so far conducted have shown that systemic antibacterials are of no value in preventing bacterial infections in these conditions. (Conclusions)
