ABSTRACT
OBJECTIVE: In this study, we have created and validated the Spanish translation of the Reflux Symptom Index (Sp-RSI). MATERIALS AND METHODS: RSI was translated according to the World Health Organization recommendation for the translation and adaptation of instruments. The final version of the Sp-RSI was administered twice (day 0 and day 7) to 150 participants with and without laryngopharyngeal reflux symptoms. Reliability was measured with Cronbach α, and temporal stability was measured with intraclass correlation coefficient. RESULTS: One hundred fifty participants were included. Internal consistency of the Sp-RSI measured with Cronbach α was 0.872. A subgroup analysis was performed according to age (<55 and >55 years) and sex (female, male), with Cronbach α values of 0.854, 0.869, 0.852, and 0.897, respectively. The intraclass correlation coefficient was 0.987. According to age (<55 and >55 years) and sex (female, male), the intraclass correlation coefficients were 0.990, 0.984, 0.987, and 0.987, respectively. CONCLUSIONS: The Sp-RSI reported a very high internal consistency and reliability. It is, therefore, a valid, inexpensive, and reliable tool for assessing laryngopharyngeal reflux symptoms and may be used for screening among the Spanish-speaking medical community.
Subject(s)
Gastroesophageal Reflux/diagnosis , Severity of Illness Index , Adolescent , Adult , Aged , Aged, 80 and over , Female , Humans , Language , Male , Middle Aged , Spain , Surveys and Questionnaires , Young AdultABSTRACT
Objective Laryngopharyngeal reflux (LPR) is a common illness of otolaryngology visits. Over the past few years, pepsin has become a promising marker of LPR. The objective of the present research is to analyze the existing literature using pepsin as a diagnostic tool of LPR through a systematic review. Data Sources PubMed (Medline), Trip Database, Cochrane Library, EMBASE, SUMsearch, and Web of Science. Review Methods The outcome assessed was the presence of pepsin in LPR patients. We included articles in which pepsin was studied in LPR patients (clinically suspected or with confirmed diagnosis). Studies with no control group, comparison group, and/or a sample size lower than 20 patients were excluded. Results Twelve studies were included. All included studies, with the exception of 2, found statistically significant differences for pepsin in cases compared with healthy controls. Conclusion Pepsin might be a reliable marker in LPR patients, although questions remain about optimal timing, location, nature, and threshold values for pepsin testing. Future investigations are necessary to clarify the best method to use pepsin in the diagnostic process of LPR.
Subject(s)
Laryngopharyngeal Reflux/diagnosis , Pepsin A/analysis , Biomarkers/analysis , Humans , Laryngopharyngeal Reflux/metabolism , Pepsin A/biosynthesis , Reproducibility of Results , Saliva/chemistryABSTRACT
Los linfomas constituyen la segunda causa de neoplasia en cabeza y cuello. El linfoma de Hodgkin representa solo el 1035% de todos estos casos, donde la afectación ganglionar está presente en el 7080%. Presentamos el caso de un paciente con linfoma de Hodgkin de afectación extranodal, dada la rareza de esta entidad (AU)
Lymphomas are the second leading cause of malignancy in head and neck. Hodgkin's disease (HD) accounts for only 1035% of all cases, where the lymph node is affected in 7080%. We present the case of a patient with HD with extranodal involvement, given the rarity of this entity (AU)
Subject(s)
Humans , Male , Adult , Hodgkin Disease/diagnosis , Tonsillar Neoplasms/diagnosis , Adenoidectomy , Adenoids/pathology , Sleep Wake Disorders/etiologyABSTRACT
Lymphomas are the second leading cause of malignancy in head and neck. Hodgkin's disease (HD) accounts for only 10-35% of all cases, where the lymph node is affected in 70-80%. We present the case of a patient with HD with extranodal involvement, given the rarity of this entity.
Subject(s)
Adenoids , Hodgkin Disease/diagnosis , Pharyngeal Neoplasms/diagnosis , Adult , Humans , MaleABSTRACT
OBJECTIVE: This study was undertaken to revise the diagnostic characteristics of tuberculous otitis media (TOM), a disorder that is often diagnosed late, leading to delay in specific treatment. STUDY DESIGN AND SETTING: Retrospective study of a longitudinal series of 10 TOM patients over a 7-year period at an institutional referral center. RESULTS: Most patients showed intractable otorrhea, moderately severe hearing loss, and necrotic eardrums with granulation tissue and single perforations. Multiple perforations, facial palsy, and cervical adenopathies were rare (<10% of patients). CT generally showed soft tissue involvement of the middle ear without bone erosion. The most effective laboratory test microbiological culture of exudate (diagnostic efficacy 71%). Specific antibiotic treatment was effective in all cases. CONCLUSION: The diagnosis of TOM remains a significant challenge for otorhinolaryngologists. SIGNIFICANCE: If there are strong clinical grounds for suspicion, standard laboratory tests for tuberculosis should be repeated even if initially negative.
Subject(s)
Mycobacterium Infections/microbiology , Mycobacterium tuberculosis/isolation & purification , Otitis Media/microbiology , Otitis Media/pathology , Adolescent , Adult , Aged , Antitubercular Agents/therapeutic use , Biopsy , Child, Preschool , Diagnosis, Differential , Drug Therapy, Combination , Facial Paralysis/etiology , Female , Follow-Up Studies , Hearing Loss, Sensorineural/diagnosis , Hearing Loss, Sensorineural/etiology , Humans , Male , Middle Aged , Mycobacterium Infections/diagnosis , Mycobacterium Infections/drug therapy , Otitis Media/complications , Otitis Media/drug therapy , Retrospective Studies , Tympanic Membrane/microbiology , Tympanic Membrane/pathologyABSTRACT
OBJECTIVE: Clinical study of second primary malignancies (SPM) in patients with cancer of the head and neck (HNC). Study design and setting Retrospective study over 48 patients with SPMs culled from 636 with HNC seen in 122 months. The minimum follow-up was 18 months, and the setting for the study was the institutional referral center. RESULTS: There was association between the sites of first and second tumor. The SPMs were diagnosed with a constant rate throughout the period of study. Five year-survival rate was 29%. SPM in an advanced stage either outside of the head and neck or synchronous had poor survival. CONCLUSION: The SPMs are a growing problem with better survival after treatment of the first malignancy. SIGNIFICANCE: Regular follow-up is necessary in HNC patients to improve their survival, giving special attention to the development of SPM.
Subject(s)
Carcinoma, Squamous Cell/mortality , Head and Neck Neoplasms/mortality , Neoplasms, Second Primary/mortality , Adult , Aged , Female , Humans , Male , Middle Aged , Retrospective Studies , Survival AnalysisABSTRACT
La neuropatía auditiva (NA) fue descrita por primera vez en 1966 y se trata de un síndrome en el que se presenta una hipoacusia neurosensorial de leve o media intensidad, que puede ser progresiva, y que se asocia a una falta de discriminación del lenguaje hablado discordante con el grado de la pérdida auditiva. En los pacientes destaca una grave alteración de los potenciales evocados del tronco del encéfalo, que pueden no registrarse, con unas otoemisiones acústicas normales. Los datos de la exploración audiológica demuestran que en la NA las células ciliadas externas son normales y que la lesión debe encontrarse en las células ciliadas internas, en las sinapsis aferentes entre éstas y las terminaciones de las neuronas del ganglio de Corti, en dichas neuronas o en los axones que emiten y conforman el nervio auditivo. En cualquier caso, la causa de la mala discriminación del lenguaje parece encontrarse en una desincronización de la señal a nivel del nervio acústico. Dentro de los tratamientos que se han propuesto, el que mejor resultado da en la actualidad, en términos generales, es el implante coclear (AU)
