[Biochemical and immunological markers of autoimmune thyroiditis]. / Biokhimicheskie i immunologicheskie markery khronicheskogo limfotsitarnogo tireoidita.

Correlations between biochemical and immunological markers of programmed cell death (apoptosis), and the functional state of the thyroid gland (hyperthyroidism, euthyroidism, hypothyroidism) have been investigated in autoimmune thyroiditis (AT) (also known as chronic autoimmune thyroiditis). Annexin V, TRAIL and TNF-a, as well as DNA-hydrolyzing antibodies were used as the main markers. Increased levels of TRAIL were found in the serum of AT patients (hyperthyroidism>hypothyroidism>euthyroidism) compared with healthy individuals. The highest frequency of antibodies to denatured DNA (Abs-dDNA) had the highest frequency in AT patients (97%) compared with healthy controls. Among these patients, 75% had hyperthyroidism, 85% had hypothyroidism, and 84.7% had euthyroidism. Abs hydrolyzing activity demonstrated correlation dependence with symptoms of the thyroid dysfunction.

[The prevention and treatment of nasal liquorrhea in transnasal surgery of the base of the skull]. / Profilaktika i lechenie nazal'noĭ likvorei v transnazal'noĭ khirurgii osnovaniia cherepa.

The objective of the present study was to estimate the effectiveness of different methods for the reconstruction of defects in the base of the skull. It was shown that the use of the modern technique for this purpose decreases the risk of the development of postoperative complications. The vascularized flaps can be applied to hermetically close defects in the base of the skull during surgery with the use of the extended transnasal approach. It is concluded that the proposed procedure accelerates the healing process and allows the flaps to be used repeatedly if necessary.