Model-based analysis of arterial pulse signals for tracking changes in arterial wall parameters: a pilot study.

Arterial wall parameters (i.e., radius and viscoelasticity) are prognostic markers for cardiovascular diseases (CVD), but their current monitoring systems are too complex for home use. Our objective was to investigate whether model-based analysis of arterial pulse signals allows tracking changes in arterial wall parameters using a microfluidic-based tactile sensor. The sensor was used to measure an arterial pulse signal. A data-processing algorithm was utilized to process the measured pulse signal to obtain the radius waveform and its first-order and second-order derivatives, and extract their key features. A dynamic system model of the arterial wall and a hemodynamic model of the blood flow were developed to interpret the extracted key features for estimating arterial wall parameters, with no need of calibration. Changes in arterial wall parameters were introduced to healthy subjects ([Formula: see text]) by moderate exercise. The estimated values were compared between pre-exercise and post-exercise for significant difference ([Formula: see text]). The estimated changes in the radius, elasticity and viscosity were consistent with the findings in the literature (between pre-exercise and 1 min post-exercise: - 11% ± 4%, 55% ± 38% and 28% ± 11% at the radial artery; - 7% ± 3%, 36% ± 28% and 16% ± 8% at the carotid artery). The model-based analysis allows tracking changes in arterial wall parameters using a microfluidic-based tactile sensor. This study shows the potential of developing a solution to at-home monitoring of the cardiovascular system for early detection, timely intervention and treatment assessment of CVD.

Unitary-quantum-lattice algorithm for two-dimensional quantum turbulence.

Quantum vortex structures and energy cascades are examined for two-dimensional quantum turbulence (2D QT) at zero temperature. A special unitary evolution algorithm, the quantum lattice algorithm, is employed to simulate the Bose-Einstein condensate governed by the Gross-Pitaevskii (GP) equation. A parameter regime is uncovered in which, as in 3D QT, there is a short Poincaré recurrence time. It is demonstrated that such short recurrence times are destroyed by stronger nonlinear interaction. The similar loss of Poincaré recurrence is also seen in the 3D GP equation. Various initial conditions are considered in an attempt to discern if 2D QT exhibits inverse cascades as is seen in 2D classical turbulence (CT). In our simulation parameter regimes, no dual cascade spectra were observed for 2D QT-unlike that seen in 2D CT.

Poincaré recurrence and spectral cascades in three-dimensional quantum turbulence.

The time evolution of the ground state wave function of a zero-temperature Bose-Einstein condensate (BEC) gas is well described by the Hamiltonian Gross-Pitaevskii (GP) equation. Using a set of appropriately interleaved unitary collision-stream operators, a qubit lattice gas algorithm is devised, which on taking moments, recovers the Gross-Pitaevskii (GP) equation under diffusion ordering (time scales as length(2)). Unexpectedly, there is a class of initial states whose Poincaré recurrence time is extremely short and which, as the grid resolution is increased, scales with diffusion ordering (and not as length(3)). The spectral results of J. Yepez et al. [Phys. Rev. Lett. 103, 084501 (2009).] for quantum turbulence are revised and it is found that it is the compressible kinetic energy spectrum that exhibits three distinct spectral regions: a small-k classical-like Kolmogorov k(-5/3), a steep semiclassical cascade region, and a large-k quantum vortex spectrum k(-3). For most evolution times the incompressible kinetic energy spectrum exhibits a somewhat robust quantum vortex spectrum of k(-3) for an extended range in k with a k(-3.4) spectrum for intermediate k. For linear vortices of winding number 1 there is an intermittent loss of the quantum vortex cascade with its signature seen in the time evolution of the kinetic energy E(kin)(t), the loss of the quantum vortex k(-3) spectrum in the incompressible kinetic energy spectrum as well as the minimalization of the vortex core isosurfaces that would totally inhibit any Kelvin wave vortex cascade. In the time intervals around these intermittencies the incompressible kinetic energy also exhibits a multicascade spectrum.

Superfluid turbulence from quantum Kelvin wave to classical Kolmogorov cascades.

The main topological feature of a superfluid is a quantum vortex with an identifiable inner and outer radius. A novel unitary quantum lattice gas algorithm is used to simulate quantum turbulence of a Bose-Einstein condensate superfluid described by the Gross-Pitaevskii equation on grids up to 5760(3). For the first time, an accurate power-law scaling for the quantum Kelvin wave cascade is determined: k(-3). The incompressible kinetic energy spectrum exhibits very distinct power-law spectra in 3 ranges of k space: a classical Kolmogorov k(-(5/3)) spectrum at scales greater than the outer radius of individual quantum vortex cores and a quantum Kelvin wave cascade spectrum k(-3) on scales smaller than the inner radius of the quantum vortex core. The k(-3) quantum Kelvin wave spectrum due to phonon radiation is robust, while the k(-(5/3)) classical Kolmogorov spectrum becomes robust on large grids.

Entropic lattice Boltzmann representations required to recover Navier-Stokes flows.

There are two disparate formulations of the entropic lattice Boltzmann scheme: one of these theories revolves around the analog of the discrete Boltzmann H function of standard extensive statistical mechanics, while the other revolves around the nonextensive Tsallis entropy. It is shown here that it is the nonenforcement of the pressure tensor moment constraints that lead to extremizations of entropy resulting in Tsallis-like forms. However, with the imposition of the pressure tensor moment constraint, as is fundamentally necessary for the recovery of the Navier-Stokes equations, it is proved that the entropy function must be of the discrete Boltzmann form. Three-dimensional simulations are performed which illustrate some of the differences between standard lattice Boltzmann and entropic lattice Boltzmann schemes, as well as the role played by the number of phase-space velocities used in the discretization.

Inelastic vector soliton collisions: a lattice-based quantum representation.

Lattice-based quantum algorithms are developed for vector soliton collisions in the completely integrable Manakov equations, a system of coupled nonlinear Schrödinger (coupled-NLS) equations that describe the propagation of pulses in a birefringent fibre of unity cross-phase modulation factor. Under appropriate conditions the exact 2-soliton vector solutions yield inelastic soliton collisions, in agreement with the theoretical predictions of Radhakrishnan et al. (1997 Phys. Rev. E56, 2213). For linearly birefringent fibres, quasi-elastic solitary-wave collisions are obtained with emission of radiation. In a coupled integrable turbulent NLS system, soliton turbulence is found with mode intensity spectrum scaling as kappa(-6).