ABSTRACT
OBJECTIVE: The aim of the study was to determine the effect of mindfulness-based stress reduction (MBSR) intervention on emotion regulation and glycemic control of patients with type 2 diabetes. MATERIALS AND METHODS: Sixty patients with type 2 diabetes were recruited for this randomized controlled trial from an outpatient clinic at Imam Hospital in Iran. The intervention group participated in 8 sessions of MBSR, and the control group continued the treatment as usual. Fasting blood sugar and HbA1c were measured as two indices of glycemic control. Overall mental health, depression, and anxiety were measured using the General Health Questionnaire (GHQ-28), Hamilton Depression Rating Scale (HDRS), and Hamilton Anxiety Rating Scale (HARS), respectively. All the assessments were performed at baseline and after 8 weeks and 3 months as follow-up. RESULTS: In comparison with the control group, the MBSR intervention group showed a significant reduction on all outcome measures including FBS, HbA1C, HARS, and HDRS scores (p < 0/05). CONCLUSION: MBSR had a remarkable improvement on emotional wellbeing and glycemic control of patients with type 2 diabetes.
Subject(s)
Blood Glucose , Diabetes Mellitus, Type 2/psychology , Emotions/physiology , Mental Health , Mindfulness/methods , Quality of Life/psychology , Stress, Psychological/therapy , Anxiety/blood , Anxiety/psychology , Anxiety/therapy , Depression/blood , Depression/psychology , Depression/therapy , Diabetes Mellitus, Type 2/blood , Female , Humans , Male , Middle Aged , Stress, Psychological/blood , Stress, Psychological/psychology , Treatment OutcomeABSTRACT
BACKGROUND: Early diagnosis of acute coronary syndrome (ACS) is an important factor in reducing mortality of this disease. Cardiac troponins are not elevated within first hours. So there is a need to optimize the clinical applicability and accuracy of novel ACS markers, particularly with regard to utilizing this technique in combination with other diagnostic methods. METHODS: In this prospective study, we examined 226 patients between July 2009 and March 2010, admitted with chest pain to emergency room (ER). The study groups constisted of 120 subjects presenting with chest pain whose initial and subsequent diagnosis was unstable angina (UA), and 106 subjects whose initial diagnosis was unstable angina but subsequent diagnosis was non ischemic chest pain(NICP). For each patient electrocardiogram (ECG), cardiac troponins (cTnT), creatinine phosphokinase (CPK), IMA levels were measured. We used McNemar's test for correlated proportions and logistic regression and ROC curve for achieving better result. RESULTS: In this study median IMA values were definitely higher in patients with ACS compared with non ischemic chest pain (NICP) (p < 0.0001) (83.5 to 49.6). An IMA cut-off threshold derived from the receiver operating characteristics curve (ROC) was 85U/ml and gives 54 % (95%CI 51 to 56) sensitivity and 87 % (95%CI 83 to 92) specificity in our population. Negative predictive value was 62 % (95%CI 59 to 66). When IMA and ECG and cTnT were considered together sensitivity was 97.5 % and specificity was 63 %, respectively. CONCLUSION: Ischemia-modified albumin did not provide superior sensitivity or specificity compared with other diagnostic tests (Tab. 1, Fig. 2, Ref. 25).
