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Copy-number variation of housekeeping gene rpl13a in rat strains selected for nervous system excitability.
Kalendar, Ruslan; Belyayev, Alexander; Zachepilo, Tatiana; Vaido, Alexander; Maidanyuk, Dmitry; Schulman, Alan H; Dyuzhikova, Natalia.
Mol Cell Probes ; 33: 11-15, 2017 06.
Article in English | MEDLINE | ID: mdl-28192165

ABSTRACT

We evaluated copy number variation (CNV) for four genes in rat strains differing in nervous system excitability. rpl13a copy number is significantly reduced in hippocampus and bone marrow in rats with a high excitability threshold and stress. The observed phenomenon may be associated with a role for rpl13a in lipid metabolism.


Subject(s)
DNA Copy Number Variations/genetics , Nervous System Physiological Phenomena/genetics , Ribosomal Proteins/genetics , Animals , Bone Marrow/metabolism , Bone Marrow/physiology , Cortical Excitability/genetics , Cortical Excitability/physiology , Hippocampus/metabolism , Hippocampus/physiology , Rats
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