ABSTRACT
OBJECTIVE: To assess stroke awareness among patients presenting to the emergency department with an acute ischaemic stroke or transient ischaemic attack (TIA). METHODS: A consecutive cohort of patients presenting with a cerebrovascular event was prospectively enrolled over a 15-month period and questionnaires were administered. If the patient was unable to respond to the questions or answer the questionnaire, it was administered to the primary caregiver. Comprehension of having a cerebrovascular event, reason for delay in presentation, mode of arrival and knowledge of treatment modalities were determined. RESULTS: Only 42% of 400 patients thought they were having a stroke or TIA. The median time to presentation was 3.4 h. Delayed presentation was almost equal in men and women. When asked about onset, 19.4% thought that a stroke came on gradually and only 51.9% thought immediate presentation was crucial. 20.8% of patients had heard of thrombolysis. CONCLUSION: Community knowledge of ischaemic stroke needs to be enhanced so that individuals present earlier, leading to timely management.
Subject(s)
Ischemic Attack, Transient/psychology , Stroke/psychology , Aged , Attitude to Health , Awareness , Early Diagnosis , Emergency Service, Hospital/statistics & numerical data , Female , Humans , Ischemic Attack, Transient/therapy , Male , Patient Acceptance of Health Care/statistics & numerical data , Prospective Studies , Risk Factors , Stroke/therapy , Surveys and QuestionnairesABSTRACT
The neu oncogene, identified in ethylnitrosourea-induced rat neuroglioblastomas, had strong homology with the erbB gene that encodes the epidermal growth factor receptor. This homology was limited to the region of erbB encoding the tyrosine kinase domain. It was concluded that the neu gene is a distinct novel gene, as it is not coamplified with sequences encoding the EGF receptor in the genome of the A431 tumor line and it maps to human chromosome 17.
Subject(s)
Antigens, Neoplasm/genetics , DNA, Neoplasm/genetics , Neoplasm Proteins/genetics , Oncogenes , Receptors, Cell Surface/genetics , Animals , Chromosome Mapping , Chromosomes, Human, 16-18 , ErbB Receptors , Genes , Genetic Linkage , Humans , Neuroblastoma/genetics , Neuroglia , RatsABSTRACT
A series of rat neuro/glioblastomas all contain the same transforming gene (neu) which induces synthesis of a tumour antigen of relative molecular mass (Mr) 185,000 (p185). The neu oncogene bears homology to erb-B and the tumour antigen, p185, is serologically related to the epidermal growth factor (EGF) receptor. The two proteins, EGF receptor and p185 appear to be distinct, as they coexist in nontransformed Rat-1 cells.
