ABSTRACT
It has been established that ratibol, retabolil and solasodin in doses 5 and 10 mg/kg proved to have a slight anticoagulative effect. The same effect has been observed during 20 days of oral retabolil and solasodin intake. Ratibol was characterized by a two-step action. All three steroids activated factors II, VII, XIII and diminished factor I concentration. These changes were accomplished with the fall of antithrombin activity and decrease in resistance to streptokinase. The fibrinolysis level has been raised under the effect of the steroids studied.
Subject(s)
Androstenols/pharmacology , Blood Coagulation/drug effects , Nandrolone/analogs & derivatives , Solanaceous Alkaloids/pharmacology , Animals , Female , Fibrinolysis/drug effects , Male , Nandrolone/pharmacology , Nandrolone Decanoate , Prothrombin Time , RabbitsABSTRACT
Oral ratibol (10 mg/kg) produced in rabbits a decrease of blood coagulability (increased the time of thromboelastogram reaction, reduced the activity of prothrombin complex according to Quick, tolerance to heparin and activity of factors II, VII, XIII and concentration of factor I). The drug administration (1 mg/kg) for 20 days caused at the first stage a decrease and at the second stage an increase of blood coagulability. At a single and 20-day administration ratibol enhanced the fibrinolytic activity, reduced the resistance of fibrin clot to streptokinase and increased the antithrombin activity.
