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J Nat Prod ; 69(12): 1793-5, 2006 Dec.
Article in English | MEDLINE | ID: mdl-17190462

ABSTRACT

The absolute configuration of the two stereocenters of (+)-sporotricale (2a), a bioactive phthalide secondary metabolite, was determined through circular dichroism and by applying Mosher's method. The structure of 6-hydroxysporotricale (2c), isolated from cultures in vitro of Sporotrichum laxum, was also elucidated.


Subject(s)
Antineoplastic Agents/chemistry , Benzofurans/chemistry , Sporothrix/chemistry , Animals , Antineoplastic Agents/isolation & purification , Antineoplastic Agents/pharmacology , Benzofurans/isolation & purification , Benzofurans/pharmacology , Chickens , Chorioallantoic Membrane/drug effects , Drug Screening Assays, Antitumor , Endothelial Cells/drug effects , Fibroblast Growth Factors/drug effects , Molecular Structure , Neovascularization, Physiologic/drug effects , Stereoisomerism , Zygote/drug effects
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