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Vopr Virusol ; 33(2): 181-4, 1988.
Article in Russian | MEDLINE | ID: mdl-3137727

ABSTRACT

Preparations of human alpha- and gamma-interferon differing by the method of production and purification had different capacity of activating phagocytosis of blood polymorphonuclear leukocytes from patients with dermatoses. Native preparations of alpha- and gamma-interferon had the highest phagocytosis-activating potency. A high level of this activity was also demonstrated with human leukocyte interferon II for injections purified by highly specific methods. A concentrated preparation of human leukocyte interferon for injections with a specific activity above 1 million IU/1 mg of protein and recombinant alpha 2-interferon (reaferon) exhibited minimal phagocytosis activating effect.


Subject(s)
Interferon Type I/pharmacology , Interferon-gamma/pharmacology , Phagocytosis/drug effects , Cells, Cultured , Dose-Response Relationship, Drug , Humans , Interferon alpha-2 , Interferon-alpha , Neutrophils/drug effects , Neutrophils/immunology , Recombinant Proteins/pharmacology , Stimulation, Chemical
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