Therapeutic efficiency of early and late administration of surfactant-BL during bleomycin-induced damage to rat lungs.

Surfactant-BL was administered to rats via the inhalation route from day 1 or day 8 after intratracheal injection of bleomycin. Bronchoalveolar lavage and morphological characteristics of the lungs were compared. Administration of surfactant-BL at the early terms efficiently reduced the severity of bleomycin-induced alveolitis and atelectases.

[Clinical studies of radiation-sensitizing effects of metronidazole in patients with cancer of the uterine body]. / Klinicheskie issledovaniia radiosensibiliziruiushchego deistviia metronidazola u bol'nykh rakom tela matki.

The local use of MZ solved in DMSO makes it possible to reach high MZ concentrations (by order 6000-8000 mu g/g) in tumor tissue in the absence of a toxic effect of the drug resulting from its small doses. The results of investigation of radiation pathomorphosis show that the local use of MZ solved in DMSO enhances the damaging effect of radiation on a tumor. Some traits revealed in MZ diffusion (a raised concentration at the serous membrane) must undoubtedly lead to increased efficacy of radiation exposure in zones, responsible for local therapeutic failures. It will permit a considerable increase in the efficacy of radiation therapy of patients with cancer of the uterine body.

[Local use of metronidazole in dimethyl sulfoxide in the radiation therapy of cervical cancer]. / Lokal'noe primenenie metronidazola v dimetilsul'fokside pri luchevoi terapii raka sheiki matki.

A method of the local use of metronidazole dissolved in dimethylsulfoxide (DMSO) for cervix uteri cancer patients was worked out. Applications of 1-2 g of metronidazole were well tolerated by the patients. Metronidazole concentrations in cervical tumors were high (about 1000 micrograms/g), in the blood they did not exceed 16 micrograms/ml. Experiments showed that metronidazole in DMSO diffused in the tissue, its concentrations at a distance of 2-3 cm from the surface were 180-260 micrograms/g. The local use of metronidazole in DMSO caused an increase in the rate of tumor radiation regression.

[Role of cytoplasmic receptors in the lympholytic action of glucocorticoids and ionizing radiation]. / Izuchenie roli tsitoplazmaticheskikh retseptorov v limfoliticheskom deistvii gliukokortikoidov i ioniziruiushchego izlucheniia.

Exposure of thymocytes to 4 Gy X-radiation causes a marked change in the kinetics of accumulation of glucocorticoids in cells. The hormone-binding activity of the cytoplasmic receptors does not differ from the control level. Progesterone, a glucocorticoid antagonist, and aurin tricarboxylic acid, an inhibitor of protein receptors, protect thymocytes from the effect of glucocorticoids and ionizing radiation. It is assumed that the cytoplasmic receptor system is involved in the realization of the radiation effect.

[Relationship between the structural state of chromatin and the biosynthesis of rapidly labeling nuclear RNA in the thymuses of rats subjected to total x-irradiation]. / Sootnoshenie strukturnogo sostoianiia khromatina i biosinteza bystrometiashchikhsia iadernykh RNK v timuse krys, podvergnutykh obshchemu rentgenovskomu oblucheniiu

Accumulation of polydeoxyribonucleotides (PDN) was studied in thymus of rats, subjected to total body X-ray irradiation at doses 400 and 800 rad. The content of PDN correlated with the time of treatment; its low-polymer components prevailed after irradiation with 800 rad. Protein/DNA ratio was decreased in DNP within 30 min after the irradiation and it returned to the initial level within 4 hrs. Capacity of DNP to make a complex with actinomycin D was inhibited within 30 min; however it exceeded the control level within 4 hrs after irradiation. Biosynthesis of nuclear RNA, estimated by incorporation of 14C-uridine, was distinctly decreased within the whole experimental period.