ABSTRACT
BACKGROUND: Uncontrolled treatment-resistant hypertension (TRH), i.e., blood pressure (BP, mm Hg) ≥140/≥90mm Hg in and out of office on ≥3 different BP medications at optimal doses, is common and has a poor prognosis. Aldosterone antagonist (AA) and renin-guided therapy (RGT) are effective strategies for improving BP control in TRH but have not been compared. METHODS: A comparative effectiveness TRH pilot study of AA vs. RGT was conducted in 4 primary care clinics with 2 each randomized to AA or RGT. The primary outcome was change in clinic BP defined by means of 5 automated office BP values. Eighty-nine patients with apparent TRH were screened and 44 met criteria for true TRH. RESULTS: Baseline characteristics of 20 patients in the AA (70% Black, 45% female, mean age: 57.4 years) and 24 patients in RGT (79% Black, 50% female, 57.8 years) arms were similar with baseline BP 162±5/90±3 vs. 153±3/84±3, respectively, P = 0.11/0.20. BP declined to 144±5/86±4 in AA vs. 132±4/75±3 in RGT, P = 0.07/0.01; BP was controlled to JNC7 (Seventh Joint National Committee Report) goal in 25% vs. 62.5%, respectively, P < 0.01. Although BP changes from baseline, the primary outcome, were not different (-17.6±5.1/-4.0±3.0 AA vs. -20.4±3.8/-9.7±2.0 RGT, P = 0.65/0.10.), more BP medications were added with AA than RGT (+0.9±0.1 vs. +0.4±0.1 per patient, P < 0.01). CONCLUSIONS: In this TRH pilot study, AA and RGT lowered BP similarly, although fewer additional medications were required with RGT. A larger comparative effectiveness study could establish the utility of these treatment strategies for lowering BP of uncontrolled TRH patients in primary care.
Subject(s)
Hypertension/drug therapy , Mineralocorticoid Receptor Antagonists/administration & dosage , Primary Health Care , Angiotensin I/blood , Female , Humans , Hypertension/blood , Male , Middle Aged , Pilot Projects , Renin/metabolismABSTRACT
BACKGROUND: In January 2002, Infection control professionals for Spartanburg Regional Healthcare System held a planning retreat focused on patient safety. The main challenge discussed was the control of antibiotic-resistant organisms. Rounds on the patient care units had revealed compliance issues with the current isolation procedures. The team developed a process improvement project coined the Effective Processes in Infection Control Project (EPIC). With a broad challenge of antibiotic resistance, the focus was narrowed to isolation precautions for methicillin-resistant Staphylococcus aureus (MRSA). METHODS: The initial stage of the EPIC project was education, followed by routine unit rounds to monitor compliance. A tool was developed to provide immediate feedback for the nursing units. Summary reports were generated for clinical directors as a method of accountability for unit leadership. Rates for facility-acquired MRSA were monitored and compared with MRSA days at risk. RESULTS: Over a 1-year period of increased accountability, the facility-acquired rate of MRSA decreased by 30%, even though the days at risk increased. The decrease was maintained during year 2. CONCLUSIONS: The results of this project point to the importance of accountability with isolation precautions in the effort to combat the spread of MRSA in the hospital setting.