ABSTRACT
Renal cell carcinomas (RCC) can be subclassified for general purposes into clear cell, papillary cell, chromophobe cell carcinomas and oncocytomas. Other tumours such as collecting duct, medullary, mucinous tubular and spindle cell and associated with Xp 11.2 translocations/TFE 3 gene fusion, are much less common. There is also a residual group of unclassified cases. Previous studies have shown that RCC has high glycolytic rates, and expresses GLUT transporters, but no distinction has been made among the different subtypes of renal cell tumours and their grades of malignancy. In clear renal cell carcinoma (cRCC) glycogen levels increase, glycolysis is activated and gluconeogenesis is reduced. The clear cell subtype of RCC is characterized histologically by a distinctive pale, glassy cytoplasm and this appearance of cRCC is due to abnormalities in carbohydrate and lipid metabolism, and this abnormality results in glycogen and sterol storage. Several isoforms of glucose carriers (GLUTs) have been identified. We show here in a panel of 80 cRCC samples a significant correlation between isoform 5 (GLUT5) and many pathological parameters such as grade of differentiation, pelvis invasion and breaking capsule. GLUT5 expression also appears to associate more strongly with the clear cell RCC subtype. These data suggest a role for the GLUT5 isoform in fructose uptake that takes place in cRCC cells and which subsequently leads to the malignant RCC progression.
Subject(s)
Carcinoma, Renal Cell/metabolism , Glucose Transporter Type 5/metabolism , Kidney Neoplasms/metabolism , Biomarkers, Tumor/metabolism , Carcinoma, Renal Cell/diagnosis , Carcinoma, Renal Cell/pathology , Carcinoma, Renal Cell/surgery , Disease Progression , Female , Fructose/metabolism , Humans , Immunohistochemistry , Kidney Neoplasms/diagnosis , Kidney Neoplasms/pathology , Kidney Neoplasms/surgery , Male , Middle Aged , Models, Biological , Neoplasm Staging/methods , Prognosis , Retrospective Studies , Tissue Array AnalysisABSTRACT
OBJECTIVE: To report a case of choriocarcinoma of the bladder during the different periods of its evolution. The anatomopathological study showing dedifferentiation of a transitional cell tumor is presented and the histogenesis of this rare tumor is discussed. METHODS: A case of a rapidly progressing transitional cell tumor of the bladder that dedifferentiated into choriocarcinoma is presented. The pathological findings of the first resections of the transitional cell tumor that progressed to choriocarcinoma are presented and the histogenesis is discussed. RESULTS/CONCLUSIONS: Choriocarcinoma of the bladder is very rare, highly malignant and carries a poor prognosis. Its origin is widely accepted to be in the dedifferentiation of a transitional cell tumor. The use of immunohistochemistry and the positivity of HCG support the diagnosis.
Subject(s)
Carcinoma, Papillary/pathology , Carcinoma, Transitional Cell/pathology , Choriocarcinoma/pathology , Urinary Bladder Neoplasms/pathology , Biomarkers, Tumor/analysis , Carcinoma, Papillary/surgery , Carcinoma, Transitional Cell/surgery , Cell Differentiation , Choriocarcinoma/chemistry , Choriocarcinoma/secondary , Chorionic Gonadotropin/analysis , Cystectomy , Disease Progression , Fatal Outcome , Humans , Lung Neoplasms/secondary , Male , Middle Aged , Neoplasm Proteins/analysis , Prostatectomy , Retrospective Studies , Urinary Bladder Neoplasms/chemistry , Urinary Bladder Neoplasms/surgery , Urinary DiversionABSTRACT
Objetivos: Presentar un caso clínico de coriocarcinoma vesical en distintos momentos de su evolución con estudio anatomo patológico amplio en donde parece demostrarse la postura de la desdiferenciación de un tumor de células transicionales.Destacar por su extraordinaria infrecuencia y rareza al coriocarcinoma vesical, el cual plantea la duda y la discusión sobre su histogénesis debatida por varios autores.Métodos Y Resultados: Se presenta un caso clínico de un tumor vesical de células transicionales que evoluciona progresiva y rápidamente, desdiferenciándose en un coriocarcinoma. Se presenta el estudio anatomo patológico de las primeras resecciones del tumor de células transicionales y su evolución hacia coriocarcinoma. Se presenta la discusión sobre la histogénesis.Conclusiones: El coriocarcinoma vesical es extremadamente raro e infrecuente, con alto grado de malignidad y mal pronóstico. Su origen mas ampliamente aceptado se encuentra en la desdiferenciación de un tumor de células transicionales. El empleo de la inmunohistoquímica y la positividad para HCG apoya el diagnostico (AU)
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