1.
Org Lett
; 14(8): 2150-3, 2012 Apr 20.
Article
in English
| MEDLINE
| ID: mdl-22475318
ABSTRACT
The first asymmetric total synthesis and determination of the absolute configuration for the neuroactive marine macrolide palmyrolide A is described. The highlight of the synthesis is macrocyclization via trans-enamide formation catalyzed by copper(I) iodide and cesium carbonate. Comparison with the authentic spectral data confirms the synthesis of (+)-ent-palmyrolide A.