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Angew Chem Int Ed Engl
; 62(5): e202213692, 2023 Jan 26.
Article
in English
| MEDLINE
| ID: mdl-36377668
ABSTRACT
We report that axially chiral biaryl boronic esters can be generated with control of atroposelectivity by a Binol-mediated dynamic thermodynamic resolution process. These intermediates can be progressed to enantioenriched products through stereoretentive functionalization of the carbon-boron bond. Finally, we have exploited this method in the first highly stereoselective total synthesis of P-streptonigrin.