1.
Biofizika
; 50(2): 281-8, 2005.
Article
in Russian
| MEDLINE
| ID: mdl-15856986
ABSTRACT
Based on the analysis of kinetic scheme of blocking of open channels at any number of blocker binding sites, the dependence of current on blocker concentration was found. A variant of this dependence for a trapping blocker was also found. The restrictions of the applicability of the Hill equation and the necessity of taking into account the dependence of the concentration of demi-maximal blocker action (IC50) on the concentration of agonist were shown.