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[Krebs cycle in tissue of rats subjected to combined effect of hypercapnia, hypoxia and cooling]. / Tsiki krebsa v takniakh krys, podvergnutykh sochetannomy vozdeistviiu giperkapnii, gipoksii i okhlazhdeniia

Baev, V I; Drukina, M A; Valeeva, G A; Volkova, Z A.

Ukr Biokhim Zh ; 47(3): 352-7, 1975.

Article in Russian | MEDLINE | ID: mdl-1216351

ABSTRACT

The content of the Krebs cycle substrates and activity of dehydrogenases corresponding to them were studied in the brain and myocardium tissues of the non-linear male rats adapted to acute hypoxia under conditions of the altered gas medium. The content of malate and succinic acid was studied in the liver and skeletal muscles only. In the brain the total activity of malate dehydrogenase (MDH, EC 1.1.1.37, 1.1.1.39) alpha-ketoglutarate dehydrogenase (KDH, EC 1.2.4.2) pyruvate dehydrogenase (PDH, EC 1.2.4.1) and isocitrate dehydrogenase (ICDH, EC 1.1.1.41-42) is shown to be decreased and kept to be lowered in all the periods of the study. No essential shifts in the activity of these dehydrogenases were found in the myocardium. The activity of succinate dehydrogenase (SDH, EC 1.3.99.1) in both tissues lowers 48 h after the effect of the mentioned factors. Simultaneously the greatest changes in the level of the substrates were observed in the myocardium, in the brain they were less developed. In the liver the content of malate increases without pronounced changes in the amount of succinic acid and in the skeletal muscles the level of malate and succinic acid lowers.

Subject(s)

Acclimatization , Citric Acid Cycle , Hypercapnia/metabolism , Hypoxia/metabolism , Animals , Brain/metabolism , Isocitrate Dehydrogenase/metabolism , Ketoglutarate Dehydrogenase Complex , Liver/metabolism , Malate Dehydrogenase/metabolism , Male , Myocardium/metabolism , Organ Specificity , Pyruvate Dehydrogenase Complex/metabolism , Rats , Succinate Dehydrogenase/metabolism

[The effect of cooling in a changing gaseous milieu on the ammonia forming and binding systems of the brain]. / Vliianie okhlazhdeniia v usloviiakh izmenennoi gozovoi sredy na sistemy obrazovaniia i sviazyvaniia ammiaka v golovnom mozge

Korostovtseva, N V; Valeeva, G A; Baev, V I.

Fiziol Zh SSSR Im I M Sechenova ; 61(3): 449-53, 1975 Mar.

Article in Russian | MEDLINE | ID: mdl-1126503

Subject(s)

Ammonia/metabolism , Brain/metabolism , Carbon Dioxide , Cold Temperature , Oxygen , Adaptation, Physiological , Alanine/metabolism , Amides/metabolism , Ammonia/biosynthesis , Animals , Aspartic Acid/metabolism , Glutamates/metabolism , Glutamine/metabolism , Male , Rats , Respiration , gamma-Aminobutyric Acid/metabolism

[Separation and quantitative determination of free amino acids in the tissues and blood by electrophoresis combined with thin layer chromatography]. / Razdelenie i kolichestvennoe opredelenie svobodnykh aminokislot v tkaniiakh i syvorotke krovi metodom elektroforeza v sochetanii s khromatografiei v tonkom sloe

Valeeva, G A; Baev, V I.

Lab Delo ; (7): 418-22, 1975.

Article in Russian | MEDLINE | ID: mdl-57315

Subject(s)

Amino Acids/analysis , Amino Acids/blood , Animals , Brain Chemistry , Child , Child, Preschool , Chromatography, Thin Layer , Electrophoresis, Cellulose Acetate , Humans , Male , Rats

[Correlation of nitrogen, carbohydrate and lipid metabolic indices in rats cooled under conditions of an altered gaseous environment]. / O sootnoshenii pokazatelei azotistogo, uglevodnogo i lipidnogo obmenov u krys, okhlazhdennykh v usloviiakh izmennoi gazovoi sredy

Baev, V I; Valeeva, G A; Bulakh, E I.

Ukr Biokhim Zh ; 46(5): 596-601, 1974.

Article in Russian | MEDLINE | ID: mdl-4463507

Subject(s)

Carbohydrate Metabolism , Hypothermia/metabolism , Lipid Metabolism , Nitrogen/metabolism , Acute Disease , Animals , Free Radicals , Hypoxia/metabolism , Male , Rats , Time Factors

[Amidation of brain proteins during the cooling of the warm-blooded organism under conditions of an altered gaseous medium]. / Amidirovanie belkov mozga pri okhlazhdenii teplokrovnogo organizama v usloviiakh izmenennoi gazovoi sredy

Valeeva, G A; Baev, V I.

Ukr Biokhim Zh ; 46(3): 333-5, 1974.

Article in Russian | MEDLINE | ID: mdl-4836938

Subject(s)

Brain/metabolism , Hypothermia, Induced , Proteins/metabolism , Amides/analysis , Amination , Ammonia/analysis , Animals , Brain Chemistry , Deamination , Hypercapnia/metabolism , Hypoxia/metabolism , Male , Rats , Time Factors

[Ammonia and glutamine concentrations in the brain of mice subjected to chilling, hypercapnia and hypoxia]. / Soderzhanie ammiaka i gliutamina v golovnom mozge krys pri okhlazhdenii, giperkapnii i gipoksii.

Korostovtseva, N V; Baev, V I; Valeeva, G A; Brattseva, S A.

Fiziol Zh SSSR Im I M Sechenova ; 59(5): 713-7, 1973 May.

Article in Russian | MEDLINE | ID: mdl-4778085

Subject(s)

Ammonia/metabolism , Brain/metabolism , Cerebellum/metabolism , Glutamine/metabolism , Hypercapnia/metabolism , Hypothermia, Induced , Hypoxia/metabolism , Adaptation, Physiological , Animals , Brain Chemistry , Hypercapnia/complications , Hypoxia/complications , Male , Mice , Recurrence , Time Factors

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