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1.
Microbiome ; 9(1): 43, 2021 02 14.
Article in English | MEDLINE | ID: mdl-33583433

ABSTRACT

BACKGROUND: Chitin ranks as the most abundant polysaccharide in the oceans yet knowledge of shifts in structure and diversity of chitin-degrading communities across marine niches is scarce. Here, we integrate cultivation-dependent and -independent approaches to shed light on the chitin processing potential within the microbiomes of marine sponges, octocorals, sediments, and seawater. RESULTS: We found that cultivatable host-associated bacteria in the genera Aquimarina, Enterovibrio, Microbulbifer, Pseudoalteromonas, Shewanella, and Vibrio were able to degrade colloidal chitin in vitro. Congruent with enzymatic activity bioassays, genome-wide inspection of cultivated symbionts revealed that Vibrio and Aquimarina species, particularly, possess several endo- and exo-chitinase-encoding genes underlying their ability to cleave the large chitin polymer into oligomers and dimers. Conversely, Alphaproteobacteria species were found to specialize in the utilization of the chitin monomer N-acetylglucosamine more often. Phylogenetic assessments uncovered a high degree of within-genome diversification of multiple, full-length endo-chitinase genes for Aquimarina and Vibrio strains, suggestive of a versatile chitin catabolism aptitude. We then analyzed the abundance distributions of chitin metabolism-related genes across 30 Illumina-sequenced microbial metagenomes and found that the endosymbiotic consortium of Spongia officinalis is enriched in polysaccharide deacetylases, suggesting the ability of the marine sponge microbiome to convert chitin into its deacetylated-and biotechnologically versatile-form chitosan. Instead, the abundance of endo-chitinase and chitin-binding protein-encoding genes in healthy octocorals leveled up with those from the surrounding environment but was found to be depleted in necrotic octocoral tissue. Using cultivation-independent, taxonomic assignments of endo-chitinase encoding genes, we unveiled previously unsuspected richness and divergent structures of chitinolytic communities across host-associated and free-living biotopes, revealing putative roles for uncultivated Gammaproteobacteria and Chloroflexi symbionts in chitin processing within sessile marine invertebrates. CONCLUSIONS: Our findings suggest that differential chitin degradation pathways, utilization, and turnover dictate the processing of chitin across marine micro-niches and support the hypothesis that inter-species cross-feeding could facilitate the co-existence of chitin utilizers within marine invertebrate microbiomes. We further identified chitin metabolism functions which may serve as indicators of microbiome integrity/dysbiosis in corals and reveal putative novel chitinolytic enzymes in the genus Aquimarina that may find applications in the blue biotechnology sector. Video abstract.


Subject(s)
Aquatic Organisms/microbiology , Bacteria/metabolism , Chitin/metabolism , Geologic Sediments/microbiology , Metagenomics , Microbiota , Seawater/microbiology , Animals , Anthozoa/microbiology , Bacteria/enzymology , Bacteria/genetics , Chitinases/genetics , Chitinases/metabolism , Microbiota/genetics , Oceans and Seas , Phylogeny , Porifera/microbiology , Symbiosis
2.
Nurse Pract ; 26(9): 14-5, 19-20, 23-7; quiz 27-9, 2001 Sep.
Article in English | MEDLINE | ID: mdl-11577531

ABSTRACT

Attention deficit hyperactivity disorder (ADHD) is a chronic childhood disorder characterized by inattention, distractibility, impulsivity, and restlessness. ADHD symptoms impair the child's ability to function at home, in school, and in the community. When ADHD is untreated, the child is at increased risk for school failure, substance abuse, and psychiatric disorders. New clinical practice guidelines from the American Academy of Pediatrics specify diagnosis and treatment for childhood ADHD, including psychosocial interventions, psychopharmacology, educational modifications, skill training, and social support.


Subject(s)
Attention Deficit Disorder with Hyperactivity/therapy , Attention Deficit Disorder with Hyperactivity/nursing , Child , Humans , Nurse Practitioners , Pediatric Nursing
3.
Geriatr Nurs ; 22(6): 294-8, 2001.
Article in English | MEDLINE | ID: mdl-11780002

ABSTRACT

A patient's desire to discuss end-of-life (EOL) choices may be among the most stressful situations for clinicians. Research confirms the importance of discussions between caregivers and patients or their surrogates about options for current and future care. Often, terminally ill patients want to discuss EOL options to avoid undue suffering, pain, and other symptoms and want some reassurance that caregivers can provide effective physical, psychosocial, and spiritual care. Patients often approach nurses first and ask for their assistance before they ask other professionals; they are more likely to ask nurses in home care than in other settings.


Subject(s)
Terminal Care , Decision Making , Humans , Quality of Life , Terminal Care/psychology , Treatment Refusal
5.
Nurse Pract ; 25(5): 18-9, 23-6, 29-30 passim; quiz 34-5, 2000 May.
Article in English | MEDLINE | ID: mdl-10826135

ABSTRACT

An estimated 18% to 25% of female primary care and prenatal patients suffer from intimate partner violence, and 31% to 44% of women report some abuse during their lifetimes. Violence is often unreported because women fear the batterer's reprisals, time-consuming court procedures, shame, blame, and unreliable legal sanctions. Screening for domestic violence should be a routine aspect of health care. Clinicians must ask direct questions about violence and detect subtle and overt clues. This article presents the historical context of violence and examines screening, evaluation, treatment, and ethics.


Subject(s)
Domestic Violence , Battered Women/statistics & numerical data , Crisis Intervention , Diagnosis , Domestic Violence/statistics & numerical data , Ethics, Medical , Female , Humans , Incidence , Interviews as Topic , Male , Physical Examination , Terminology as Topic , United States/epidemiology
6.
Med Law ; 19(4): 793-813, 2000.
Article in English | MEDLINE | ID: mdl-11289648

ABSTRACT

Clinical challenges occur when patients consider suicide. Despite improved treatment, people with cancer have an increased risk of suicide. While previous research examined patients' perspectives, this study describes the nurse's perspective of difficulty of caring for suicidal patients. Suicidal ideas constitute common psychiatric complications of cancer, however we know little of the nurse's difficulties in care giving. As part of a larger study of oncology nurses' knowledge, we randomly surveyed 1,200 clinical oncology nurses and 434 returned completed questionnaires (37%). This paper describes content analysis of oncology nurses' narratives about their difficulties responding to suicidal patients. Six categories emerged: religious/other values, uncomfortable feelings, inadequate knowledge, personal experiences, and weight of professional responsibility which made it difficult for most nurses to care for suicidal patients. Some nurses reported they had no difficulties. Care giving is also difficult because the patient's right to choose suicide may conflict with the nurse's professional obligation to prevent suicide.


Subject(s)
Attitude of Health Personnel , Neoplasms/nursing , Neoplasms/psychology , Nurse-Patient Relations , Suicide/psychology , California , Canada , Ethics, Nursing , Humans , Social Values
7.
Nurse Pract ; 23(11): 38, 43-4, 47 passim, 1998 Nov.
Article in English | MEDLINE | ID: mdl-9834504

ABSTRACT

Childhood seizures are encountered frequently in the primary care setting. Seizures can cause considerable embarrassment and discomfort--as well as dangerous consequences--if not properly treated. Accurate diagnosis often depends on history and a parent's or teacher's clear and reliable description of the seizure. About two-thirds of properly treated patients achieve seizure remission within 10 years of diagnosis. In this article, the authors review standards of treatment and present the latest findings on the treatment of epilepsy. The goal of pharmacologic treatment is to reduce the frequency of seizures with few adverse effects. Because all antiepileptic drugs affect cognition to same degree, diminishing the potential cognitive and psychosocial effects of epilepsy is also a treatment goal. Commonly used and new antiepileptic drugs are discussed. Patient education is an important part of care and requires discussion of beliefs about epilepsy, lifestyle, self-esteem, and resources.


Subject(s)
Anticonvulsants/therapeutic use , Epilepsy/drug therapy , Epilepsy/nursing , Primary Health Care , Child , Cognition , Epilepsy/psychology , Female , Humans , Life Style , Nurse Practitioners , Patient Education as Topic , Self Concept , United States
8.
AORN J ; 68(2): 252-8, 260-4, 1998 Aug.
Article in English | MEDLINE | ID: mdl-9706237

ABSTRACT

Patients' end-of-life decisions challenge nurses. Often, aggressive, life prolonging strategies create ethical dilemmas for nurses when patients decide to stop treatment. In Oregon, assisted suicide is legal and will have a profound effect on nursing practice. When a patient considers suicide, nurses need to examine the patient's mental health, symptom management, and rational decision-making ability. Evaluation of suicide risk is a priority. Nurses need to recognize that medical land psychological symptoms often trigger thoughts of suicide, but prompt treatment of pain and symptoms also reduces suicide risk. Ethical issues and guidelines for management of patients considering suicide and evaluation of rationality are presented.


Subject(s)
Ethics, Nursing , Suicide , Terminally Ill/psychology , Thinking , Aged , Depression/etiology , Depression/nursing , Female , Humans , Palliative Care , Patient Advocacy , Suicide/psychology , Suicide, Assisted/psychology
9.
Cancer Nurs ; 20(3): 168-77, 1997 Jun.
Article in English | MEDLINE | ID: mdl-9190091

ABSTRACT

Although depressive disorders are common among 20-25% of people with cancer, they are frequently unrecognized. Untreated depression in the presence of comorbid conditions may result in more frequent clinic visits, increased costs, extended hospitalization, and reduced compliance and quality-of-life. Oncology clinicians need not have psychiatric expertise to play a major role in the detection and treatment of depression and in the prevention of suicide. Using early detection and screening tools, the nurse can identify depressed patients and can collaborate in their treatment. Approximately 80-90% of depressed patients are effectively treated with psychotherapy, and/or pharmacologic, or somatic, interventions. Failure to diagnose or reluctance to treat depression among patients with cancer is a common error and can increase morbidity and mortality.


Subject(s)
Depressive Disorder/diagnosis , Depressive Disorder/therapy , Neoplasms/psychology , Adult , Antidepressive Agents/therapeutic use , Depressive Disorder/etiology , Female , Humans , Mass Screening , Middle Aged , Nursing Assessment , Psychiatric Status Rating Scales , Psychotherapy , Social Support
10.
Nurs Outlook ; 45(2): 93, 1997.
Article in English | MEDLINE | ID: mdl-9127351
11.
J Assoc Nurses AIDS Care ; 8(2): 72-82, 1997.
Article in English | MEDLINE | ID: mdl-9152892

ABSTRACT

Alfredo's story is part of a larger phenomenological study of nursing, self care, and HIV disease that incorporated the anthropological tradition of reconstructing a life-story in the person's own words. This exemplar emphasizes Alfredo's shifts perspective organized around three turnings, or shifts in perspective, which are illustrated with narrative text and discussed. The three turnings include becoming HIV-infected, becoming a positive force, and reclaiming self. Implications for nursing include the importance of story telling in life history, the value of knowing the patient as a person, the positive impact of negative events, and the educational impact of a paradigm case.


Subject(s)
HIV Infections/psychology , Adaptation, Psychological , Autobiographies as Topic , HIV Infections/nursing , Humans , Male , Patient Care Planning , Suicide/psychology , United States
12.
J Assoc Nurses AIDS Care ; 8(1): 51-67, 1997.
Article in English | MEDLINE | ID: mdl-9085249

ABSTRACT

Many people with HIV suffer from depression, which responds to antidepressants, counseling, education, and cognitive strategies. Untreated depression hinders treatment compliance and increases risk of suicide. Management and complications of major depression are described. The evaluation of rational suicide is examined. Clinicians who treat this population need to respond therapeutically to patients with depression and suicidal ideas.


Subject(s)
Antidepressive Agents/therapeutic use , Depressive Disorder/therapy , HIV Infections/psychology , Antidepressive Agents/adverse effects , Counseling , Depressive Disorder/etiology , Depressive Disorder/physiopathology , Humans , Psychotherapy , Risk Factors , Suicide/psychology
13.
Nurse Pract ; 21(8): 26, 32-4, 37-8, passim, 1996 Aug.
Article in English | MEDLINE | ID: mdl-8871988

ABSTRACT

Anxiety is one of the common yet underdiagnosed mental health problems of Americans; as many as 20% of people seeking primary care have symptoms of treatable anxiety disorders. Untreated anxiety increases costly visits to urgent care. Clinicians need to screen for anxiety among patients at risk who have physical symptoms such as shortness of breath, nervousness, gastrointestinal upset, palpitations, muscle aches, tension, and insomnia. Other diagnostic clues include restlessness, nervousness, phobias, trembling, fatigue, and shaking. Onset typically occurs in the 20s but may occur at any age. Symptoms of two anxiety disorders, generalized anxiety disorder (GAD) and panic disorder, are discussed. A combination of treatments including antidepressant and anxiolytic medications, behavioral treatments, education (e.g., self-management, relaxation), and counseling (e.g., coping strategies) have high success rates; psychiatric consultations or referrals are useful.


Subject(s)
Anxiety , Panic Disorder , Anxiety/diagnosis , Anxiety/physiopathology , Anxiety/therapy , Diagnosis, Differential , Humans , Panic Disorder/diagnosis , Panic Disorder/physiopathology , Panic Disorder/therapy , Primary Health Care/methods , Psychotherapy/methods , Psychotropic Drugs/therapeutic use
15.
Clin Nurs Res ; 3(4): 316-33, 1994 Nov.
Article in English | MEDLINE | ID: mdl-7703866

ABSTRACT

The stigma attached to suicide, and a qualitative analysis of psychiatric patients' suicide messages that emerged from a study of psychological characteristics and communications of suicidal psychiatric patients, are described. In this retrospective study, the suicide messages from clinical records of 25 suicide completers and a matched cohort of suicide attempters from a Veterans Affairs Medical Center were analyzed. A qualitative method developed by Leenaars in 1992 was used to examine themes in suicide messages. Analysis indicated that clear suicidal messages are sent by most psychiatric patients, and that some useful distinctions exist between messages of completers and attempters. Suicide messages offer worthwhile indicators of suicide that assist clinicians in their therapeutic and preventive roles. The themes of the psychiatric patients' suicide messages included unbearable psychological pain, interpersonal relations, and aggression-rejection. The present study enhances clinicians' recognition of themes in suicide messages and improves the estimation of suicide risk among psychiatric patients.


Subject(s)
Communication , Mental Disorders/psychology , Stereotyping , Suicide/psychology , Adult , Aged , Case-Control Studies , Humans , Male , Mental Disorders/nursing , Middle Aged
16.
J Assoc Nurses AIDS Care ; 5(6): 19-29, 1994.
Article in English | MEDLINE | ID: mdl-7865803

ABSTRACT

Suicidal acts among people with HIV disease exceed those among the general population. Stress from the HIV diagnosis, treatment, and medications can lead to depression, which increases suicide risk. High quality care of depressed persons depends on sound scientific knowledge of evaluation of suicide. Incidence, epidemiology, risk factors, evaluation, and treatment of suicidal people are the core of this article. A patient's comment, "I'd be better off dead," deserves investigation as a cry for help and a clue to impending suicide.


Subject(s)
Depression/psychology , HIV Infections/psychology , Nursing Assessment , Suicide/psychology , Adult , Depression/diagnosis , Depression/nursing , Female , HIV Infections/nursing , Humans , Male , Nurse-Patient Relations , Risk Assessment , Suicide Prevention
17.
Am J Orthopsychiatry ; 64(4): 614-21, 1994 Oct.
Article in English | MEDLINE | ID: mdl-7847577

ABSTRACT

A patient's suicide may evoke the therapist's personal grief and influence professional competence or suicide prevention skills. The incidence of suicide by patients in therapy is examined and empirical studies of therapist response--which commonly includes grief, guilt, self-blame, anger, fear, and self-doubt--are reviewed. Bereavement theories and support programs are described.


Subject(s)
Attitude of Health Personnel , Bereavement , Professional-Patient Relations , Psychotherapy , Suicide/psychology , Adaptation, Psychological , Female , Humans , Liability, Legal , Male , Middle Aged , Psychotherapy/legislation & jurisprudence , Social Support , Suicide/legislation & jurisprudence , Suicide Prevention
18.
Cancer Nurs ; 17(4): 318-25, 1994 Aug.
Article in English | MEDLINE | ID: mdl-7954379

ABSTRACT

Bereavement, a well-established threat to health and work performance, is one of the most universal human responses that nurses experience. Because patient death is frequent, oncology nurses commonly experience bereavement; they may identify with the family, feel sad at the death, or feel awkward in responding to a death. After patients die, nurses manage bereavement tasks such as making sense of the death, managing mild to intense emotions, and realigning relationships. These tasks become more difficult when multiple deaths are encountered or when a conflict about the death occurs. Understanding theories, models, tasks, and factors influencing their bereavement may help nurses to facilitate their own grief and to reduce bereavement overload. The purpose of this article is to review knowledge and factors that influence nurses' bereavement and offer guidelines for managing grief. Information for this article was derived from several sources: (a) a review of existing literature; (b) clinical experience; and (c) analysis of personal inventories from over 300 nurses attending the authors' bereavement workshops.


Subject(s)
Attitude of Health Personnel , Attitude to Death , Bereavement , Neoplasms/nursing , Nurses/psychology , Adaptation, Psychological , Affect , Existentialism , Humans , Models, Psychological , Neoplasms/psychology , Nurse-Patient Relations , Oncology Nursing/methods , Terminal Care/methods , Terminal Care/psychology
19.
Cancer Pract ; 2(3): 209-16, 1994.
Article in English | MEDLINE | ID: mdl-8055025

ABSTRACT

Nurses' knowledge of suicide has been underinvestigated. This article summarizes a survey of oncology nurses' knowledge and misconceptions about suicide. Nurses' knowledge of risk factors, suicide potential, and management of a suicidal patient were examined after nurses read a vignette about a suicidal patient with cancer. Analysis included descriptive statistics and content analysis. Approximately 20% of nurses underestimated the patient's suicide risk. Nurses correctly identified an average of three of eight risk factors, but 61% misidentified worries and fears as suicide risk factors or indicators of suicide risk. More than 60% of nurses correctly identified saying goodbye, giving away a treasured object, being a widower, and wishing to be dead as risk factors. Few knew that race/ethnicity (3.23%), male gender (23.66%), and age (31.18%) were risk factors. Undiagnosed mental disorders also increase suicide risk. Physicians and nurses often fail to ask oncology patients about depression, and depressed patients often report only physical symptoms and minimize their depression or suicidal ideas. Before committing suicide, 8 of 10 suicidal people had asked for better management of their physical symptoms, but their suicide risk was not detected. After recognizing any indicator of suicide risk, a nurse should assess risk factors, detect clues, and estimate individual lethality. Few (15.12%) nurses asked about a suicide plan as a nursing assessment, and 37% of the nurses used consultation. Less than one-third of nurses recommended providing safety, protecting the patient, or taking suicide precautions. Such evidence indicates the need for education to enhance knowledge and skill building to improve the interviewing and care of suicidal patients.


Subject(s)
Health Knowledge, Attitudes, Practice , Neoplasms/psychology , Nursing Staff, Hospital , Patient Care Planning , Suicide , Adult , Female , Humans , Male , Middle Aged , Nursing Assessment , Nursing Staff, Hospital/education , Nursing Staff, Hospital/psychology , Risk Factors , Suicide/psychology , Suicide/statistics & numerical data
20.
Cancer Pract ; 2(1): 65-71, 1994.
Article in English | MEDLINE | ID: mdl-8055008

ABSTRACT

The stress, diagnosis, and treatment of cancer cause substantial psychiatric morbidity that is treatable. Chemotherapy or other cancer treatments cause 40% to 60% of patients' emotional distress. Major depression develops in approximately 25% of patients with cancer, and less severe depressive symptoms develop in many patients, but fewer than half of the patients with symptoms are offered treatment. Alleviating major depression improves the quality of life for these patients with cancer. These patients, particularly during terminal illness, have an increased risk of suicide. Clinicians proficient in psychosocial assessment can detect subtle signs, monitor risk factors, reduce major depression with cognitive strategies, and prevent complications. Untreated major depression lowers life expectancy and treatment compliance and increases risk of suicide and cardiac disease. In this article, incidence of major depression among patients with cancer is discussed. Guidelines for diagnosis, correcting myths, and detecting major depression are suggested. Effective cognitive strategies for intervention are described; medical treatment is briefly reviewed. Detection and evaluation of suicide risk are discussed.


Subject(s)
Depressive Disorder/diagnosis , Neoplasms/psychology , Cognitive Behavioral Therapy , Depressive Disorder/epidemiology , Depressive Disorder/etiology , Depressive Disorder/therapy , Humans , Incidence , Nursing Assessment , Risk Factors
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