The possible predictive value of muscle ultrasound in the diagnosis of ICUAW in long-term critically ill patients.

PURPOSE: Intensive Care Unit acquired weakness (ICUAW) occurs commonly. Muscular ultrasonography allows visualization and classification of muscle characteristics. The aims of this study were to evaluate peripheral and respiratory muscles, their changes during long-term ICU stays, and the possible diagnostic predictive value of ICUAW as compared to the Medical Research Council strength score (MRC-SS). MATERIALS: 50 mechanically ventilated patients were enrolled. Within 48 h after ICU admission (T1), patients underwent muscular ultrasound (rectus femoris cross sectional area (RFCSA), pennation angle, diaphragm, and parasternal intercostal). All the same measures were repeated at days 3 (T3) and 7 (T7). Muscle strength assessment was performed using the MRC-SS. RESULTS: No significant differences were found regarding age, sex, weight, height, or BMI values, in those who developed ICUAW according to MRC-SS. The RF pennation angle, however, significantly changed between T7-T1 in patients who developed ICUAW and was. Found to be the best predictor of ICUAW. CONCLUSIONS: Quadriceps and respiratory muscles were altered within the first week of mechanical ventilation. The loss of pennation angle offers high diagnostic accuracy for ICUAW, allowing for an earlier diagnosis before patients became able to perform volitional tests.

Aicardi Syndrome: Key Fetal MRI Features and Prenatal Differential Diagnosis.

OBJECTIVE: This study was aimed to investigate the prenatal findings in Aicardi syndrome (AIC) by intrauterine magnetic resonance imaging (iuMRI) suggesting possible diagnostic criteria and differential diagnosis. METHODS: The iuMRI features of nine AIC confirmed cases were described and then compared with those of postnatal MRI. Furthermore, all iuMRI cases with both corpus callosum (CC) agenesis-dysgenesis and cortical malformation (AIC mimickers) were retrospectively reviewed and compared with iuMRI AIC cases, in order to identify possible neuroradiological predictors of AIC syndrome. For this purpose, Chi-square statistic and binary logistic regression analysis were performed. RESULTS: In all AIC cases, iuMRI was able to detect CC agenesis-dysgenesis and cortical development anomalies. Postnatal MRI revealed some additional findings mainly including further cystic lesions and in two cases small coloboma. A statistically significant difference between AIC and AIC mimicker were found regarding sex, nodular heterotopias, posterior fossa abnormalities, coloboma, and cortical gyration abnormalities. The most predictive variables in the logistic regression model were cortical gyration abnormalities, coloboma, and sex. CONCLUSION: The iuMRI findings may suggest prenatal diagnosis of AIC syndrome with significant impact on parental counseling. Among possible differential diagnoses, tubulinopathies emerged.