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Acta Haematol ; 99(1): 18-21, 1998.
Article in English | MEDLINE | ID: mdl-9490560

ABSTRACT

B-cell chronic lymphocytic leukaemia (B-CLL) is characterized by a high frequency of infections, including those of viral aetiology. Previous reports have demonstrated a specific immunologic response to influenza virus vaccine in B-CLL patients with normal IgG levels. In this study, we have evaluated different immunophenotypically defined B and T cell subsets in 18 B-CLL patients before immunization with killed-influenza-virus vaccine. A correlation between immunological response to vaccination and both absolute numbers of CD4+/CD45RA+ naive T cells and CD5- B cells was found. These data may suggest a supporting role of the CD4+/CD45RA+ T cell subset in the specific antibody response to vaccination with influenza virus vaccine in B-CLL patients.


Subject(s)
CD4-Positive T-Lymphocytes/immunology , Influenza Vaccines/immunology , Leukemia, Lymphocytic, Chronic, B-Cell/immunology , T-Lymphocyte Subsets/immunology , Adult , Aged , Antibodies, Viral/biosynthesis , Female , Flow Cytometry , Humans , Immunophenotyping , Leukemia, Lymphocytic, Chronic, B-Cell/pathology , Leukocyte Common Antigens/metabolism , Male , Middle Aged
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