ABSTRACT
Interstitial lung diseases are a broad, diverse, challenging group of diseases, most of them chronic whose prognosis is not good. In the last two decades there have been considerable advances in the knowledge of the epidemiology, pathological and genetic bases and treatment of several of these diseases. This article summarizes and presents updated information about their classification, new knowledge on genetics and treatments in idiopathic pulmonary fibrosis, advances in the diagnosis and management of hypersensitivity pneumonitis and a review of the broad spectrum of interstitial diseases associated with connective tissue diseases. Several clinical trials are currently underway whose results will be available in the coming years and will provide more information and tools to improve the treatment of these patients.
Subject(s)
Lung Diseases, Interstitial/classification , Lung Diseases, Interstitial/diagnosis , Prognosis , Connective Tissue Diseases/diagnosis , Diagnosis, Differential , Idiopathic Pulmonary Fibrosis/diagnosis , Alveolitis, Extrinsic Allergic/diagnosisABSTRACT
Interstitial lung diseases are a broad, diverse, challenging group of diseases, most of them chronic whose prognosis is not good. In the last two decades there have been considerable advances in the knowledge of the epidemiology, pathological and genetic bases and treatment of several of these diseases. This article summarizes and presents updated information about their classification, new knowledge on genetics and treatments in idiopathic pulmonary fibrosis, advances in the diagnosis and management of hypersensitivity pneumonitis and a review of the broad spectrum of interstitial diseases associated with connective tissue diseases. Several clinical trials are currently underway whose results will be available in the coming years and will provide more information and tools to improve the treatment of these patients.
Subject(s)
Lung Diseases, Interstitial/classification , Lung Diseases, Interstitial/diagnosis , Alveolitis, Extrinsic Allergic/diagnosis , Connective Tissue Diseases/diagnosis , Diagnosis, Differential , Idiopathic Pulmonary Fibrosis/diagnosis , PrognosisABSTRACT
Lipoid pneumonia is an unusual cause of aspiration pneumonia with diverse radiologic manifestations. One of these are pulmonary nodules in which the main differential diagnosis is pulmonary carcinoma. We report an 85 years old male, an 85 years old female and a 34 years old male in whom percutaneous biopsies of suspicious nodules were compatible with lipoid pneumonia.
Subject(s)
Humans , Male , Female , Adult , Aged, 80 and over , Pneumonia, Lipid/diagnostic imaging , Pneumonia, Lipid/pathology , Biopsy , Tomography, X-Ray ComputedABSTRACT
Lipoid pneumonia is an unusual cause of aspiration pneumonia with diverse radiologic manifestations. One of these are pulmonary nodules in which the main differential diagnosis is pulmonary carcinoma. We report an 85 years old male, an 85 years old female and a 34 years old male in whom percutaneous biopsies of suspicious nodules were compatible with lipoid pneumonia.
Subject(s)
Pneumonia, Lipid/diagnostic imaging , Adult , Aged, 80 and over , Biopsy , Female , Humans , Male , Pneumonia, Lipid/pathology , Tomography, X-Ray ComputedABSTRACT
In renal transplants patients, metastatic pulmonary calcifications have been reported occasionally when the grafts are dysfunctional and rarely when they are functioning normally. We report a male who received a renal allograft in 1994 at the age of 61 years. Nineteen years later a routine chest X ray showed diffuse infiltrates and a CT scan showed diffuse calcifications in both lungs. These were interpreted as metastatic pulmonary calcifications. The last available laboratory determinations were a serum creatinine of 1.4 mg/dl and urinary protein excretion of 255 mg/24 hours. No further studies were done since the patient experienced a sudden death due to an acute myocardial infarction.
Subject(s)
Aged, 80 and over , Humans , Male , Calcinosis/etiology , Kidney Transplantation/adverse effects , Lung Diseases/etiology , Calcinosis/diagnosis , Creatinine/blood , Fatal Outcome , Lung Diseases/diagnosis , Proteinuria/blood , Renal Insufficiency, Chronic/complications , Renal Insufficiency, Chronic/surgery , Tomography, X-Ray Computed , Transplantation, Homologous/adverse effectsABSTRACT
In renal transplants patients, metastatic pulmonary calcifications have been reported occasionally when the grafts are dysfunctional and rarely when they are functioning normally. We report a male who received a renal allograft in 1994 at the age of 61 years. Nineteen years later a routine chest X ray showed diffuse infiltrates and a CT scan showed diffuse calcifications in both lungs. These were interpreted as metastatic pulmonary calcifications. The last available laboratory determinations were a serum creatinine of 1.4 mg/dl and urinary protein excretion of 255 mg/24 hours. No further studies were done since the patient experienced a sudden death due to an acute myocardial infarction.
