Development of a New Microextraction Fiber Combined to On-Line Sample Stacking Capillary Electrophoresis UV Detection for Acidic Drugs Determination in Real Water Samples.

A new analytical method coupling a (off-line) solid-phase microextraction with an on-line capillary electrophoresis (CE) sample enrichment technique was developed for the analysis of ketoprofen, naproxen and clofibric acid from water samples, which are known as contaminants of emerging concern in aquatic environments. New solid-phase microextraction fibers based on physical coupling of chromatographic supports onto epoxy glue coated needle were studied for the off-line preconcentration of these micropollutants. Identification and quantification of such acidic drugs were done by capillary zone electrophoresis (CZE) using ultraviolet diode array detection (DAD). Further enhancement of concentration sensitivity detection was achieved by on-line CE "acetonitrile stacking" preconcentration technique. Among the eight chromatographic supports investigated, Porapak Q sorbent showed higher extraction and preconcentration capacities. The screening of parameters that influence the microextraction process was carried out using a two-level fractional factorial. Optimization of the most relevant parameters was then done through a surface response three-factor Box-Behnken design. The limits of detection and limits of quantification for the three drugs ranged between 0.96 and 1.27 µg∙L-1 and 2.91 and 3.86 µg∙L-1, respectively. Recovery yields of approximately 95 to 104% were measured. The developed method is simple, precise, accurate, and allows quantification of residues of these micropollutants in Genil River water samples using inexpensive fibers.

Una aproximacón cualitativa a la violencia hacia la mujer en un asentamiento humano de Villa el Salvador / A qualitative aproximacon violence against women in a human settlement of Villa el Salvador

De acuerdo al modelo ecológico, la violencia hacia la mujer es determinada por diversos factores que interactúan entre sí, de esta manera influyen en su aparición y mantenimiento diversos elementos de la esfera personal de los miembros de la familia así como factores sociales, económicos y culturales del contexto familiar.Desde esta perspectiva, se realizó un estudio cualitativo en el que intervinieron 33 mujeres madres de un asentamiento humano (AAHH) del distrito de villa el salvador. A través de grupos focales, se exploraron las principales características de la violencia hacia las mujeres en la zona, los factores que la detienen y las creencias que mantienen a la mujer en una relación violenta. Se describen los principales hallazgos los cuales son fundamentados con extractos del discurso de las mujeres. Finalmente se discuten los principales resultados tomando en cuenta las características de la zona de estudio.

Estudio preliminar del impacto socioeconómico sobre los puntajes de una batería multidimensional de aptitudes en niños preescolares / A preliminary study on the socioeconomic impact on the scores of a set of multidimensional aptitude tests in pre-school children

El presente estudio explora las relaciones entre nivel socioeconómico, género y tipo de centro educativo preescolar y el desempeño cognitivo de niños preescolares (N = 323) de Lima (Perú), con una prueba multidimensional de aptitudes. Con la aplicación de la técnica multivariada de análisis de perfiles se hallaron diferencias estadísticamente significativas y de moderada magnitud del efecto en los puntajes cognitivos, debidas a la ubicación del centro educativo; no se detectaron diferencias que se atribuyan al género y al tipo de centro. Se trabajó en base a tres hipótesis: La primera es la hipótesis de igualdad de niveles, en la que se examinan las diferencias que en promedio existen entre los dos grupos. La segunda es la hipótesis de igualdad de la dispersión, que examina si las variables de respuesta (puntajes en las subescalas) tienen la misma respuesta en promedio. Y la tercera, la hipótesis de paralelismo, que prueba si el patrón de elevaciones en el perfil es similar entre los dos grupos. Los resultados fueron evaluados con respecto a la consistencia interna y a la definición del nivel socioeconómico (ubicación geográfica). Se discuten las diferencias halladas en el aspecto socioeconómico y relacionándolas con la bibliografía sobre el tema y la utilidad de la batería multidimensional de aptitudes para niños preescolares. Es importante destacar que el estudio reporta información normativa acerca del desempeño de los niños preescolares, en lo que respecta al género y ubicación de los centros educativos y su carácter correlacional y la magnitud del efecto de los resultados.

The present study explores the relationship between socioeconomic level, gender and type of pre-school education center, and cognitive development in 323 pre-schoolers in Lima (Perú), using a multidimensional aptitude test. By applying the multivariate technique, we found statistical significant differences and medium size effects on the cognitive scores due to the educational center location, whereas gender and type of educational center differences were not found. The results were considered taking into account reliability levels and also according to the definition of socioeconomic levels. The differences found are discussed based on other articles as well as on the usefulness of the multidimensional aptitude tests for pre-schoolers. The sample consisted of 323 children of 5 years old, 167 boys and 156 girls, who go to both private and public pre-schools in a district of Lima. The proportion of public pre-school students (67.2%) was double the amount of private pre-school students (32.8%). Moreover, the private pre-schools had been recently formed (4 to 5 years before) and had children from families with a medium or medium to low socioeconomic level. In order to assess general and relevant aspects of pre-school learning, we applied a pre-school diagnostic test (De la Cruz, 1991), which can be used at a pre-school level (4-5 year-olds). This test contains the following areas: Verbal concepts, Quantitative concepts and Auditive memory, Visual perceptual aptitude and Visual-motor coordination. It is a potentia test because the time varies from one student to another so as to allow every child to answer every item. Furthermore, it is also a maximum performance test because the student tries to obtain the best possible score. We contacted several educational centers (private and public) from three different districts in Lima which accepted to participate in this study. The time of application of the test varied considering: individual skills, the number of children in the collective application, the presence of a teacher's aide for the collective application, and the attitude and motivation of the students. We used MANOVA to analyze profiles, a post hoc univariate contrast, and effect size estimations such as Cohen's d. Our study was based on three hypotheses: The first hypothesis was on the equality of levels (variability between subjects) that explores the differences that exist between both groups separately. As a result, we found no correlation between test performance and gender or school location. However, when considering type of school (public or private), we did find significant differences in one scale: Auditive memory, which was higher in public schools. The second hypothesis was the equality of dispersion (within-group differences), to identify if the answer variables have the same answers on average. We found similarities regarding school conditions (public or private); but there were small differences between gender and school location. The third hypothesis was regarding parallelism, which tests whether the pattern of elevations on the profile is similar between the two groups or not. We did not find important statistical dispersions and the effect size was small. The results coincide with other studies on the correlation between gender and socioeconomic level, and cognitive development. Among some of the limitations of our study, we list the following: for example, we used the school location to determine the children's socioeconomic level. Therefore, there were also extreme scores (outliers), which could vary the central tendency estimations and the dispersion. However, they were not trimmed, since in a previous unreported analysis without these data, researchers found only minimum changes. We also had occasional difficulties in applying the tests, due to the children's disposition to participate as well as their reaction concerning the test situation, which could have added random error on the results. However, we presume their negative reactivity was reduced because of the playful manner in which the tests were presented. The results of our research shed normative information regarding the performance of preschoolers due to gender and location of their educational centers. It is important to emphasize correlations as well as effect size of the results so as not to reach erroneous conclusions.