ABSTRACT
Moyamoya syndrome is a rare chronic progressive disease of brain vessels in which certain arteries in the brain are constricted. During the disease a collateral circulation develops around the blocked vessels to compensate for the blockage, and on angiography these collateral vessels have the appearance of a "puff of smoke". Moyamoya syndrome is extremely rare disease, especially outside of Japan We describe a clinical case of a 27-year-old patient from Tomsk with Moyamoya disease. The clinical features are an acute stroke in the right middle cerebral artery with dysarthria and paralysis of VII and XII cranial nerves. The diagnosis of moyamoya is suggested by MRI-angiogram results in accordance to the diagnostic criteria.
Subject(s)
Brain Ischemia/diagnosis , Moyamoya Disease/diagnosis , Adult , Brain/pathology , Brain Ischemia/complications , Dysarthria/diagnosis , Dysarthria/etiology , Facial Nerve Diseases/diagnosis , Facial Nerve Diseases/etiology , Humans , Hypoglossal Nerve Diseases/diagnosis , Hypoglossal Nerve Diseases/etiology , Magnetic Resonance Angiography , Male , Middle Cerebral Artery/pathology , Moyamoya Disease/complications , Moyamoya Disease/surgery , Treatment OutcomeSubject(s)
Lymphocytes/metabolism , Muscular Diseases/metabolism , Polysaccharides, Bacterial/metabolism , Receptors, Cell Surface/metabolism , Streptococcus pyogenes/metabolism , Thymus Gland/metabolism , Adolescent , Child , Child, Preschool , Humans , Lymphocytes/drug effects , Lymphocytes/pathology , Microscopy, Phase-Contrast , Microscopy, Ultraviolet , Muscular Diseases/pathology , Receptors, Cell Surface/drug effects , Thymectomy , Thymus Gland/drug effects , Thymus Gland/pathologyABSTRACT
Increased level of cytogenetic damages was observed in lymphocytes of 10 patients with muscular dystrophy (Duchenne, Erba, Landuzi--Degerin). Analysis of DNA repair synthesis revealed inhibition of this process in lymphocytes of 10 patients observed. On the other hand, decreased reactivation of vaccinia virus and increased level of virus mutagenesis induced by 4-nitroquinoline-1-oxide and bleomycin was noted in the experiments with lymphocytes of 3 patients observed.
Subject(s)
DNA Repair , Genes , Lymphocytes/metabolism , Muscular Dystrophies/genetics , 4-Nitroquinoline-1-oxide/toxicity , DNA/biosynthesis , Humans , Lymphocytes/microbiology , Mutagens , Vaccinia virus/genetics , Virus Activation/drug effectsABSTRACT
Immunofluorescence was used to demonstrate that in progressive muscular dystrophy, myoid cells in the patients' thymus undergo profound changes which affect the processes of their formation, differentiation and maturation. Pronounced changes in the myoid cells were disclosed in two forms of myopathy. These changes lie in the increased number of myoid antigens in Erb's myopathy, whereas in Duchenne's myopathy, they manifest in the diminution of the number of myoid antigens in the internal environment of the thymus. It is suggested that the differences in the pattern of changes in the myoid cells, apart from other factors, apparently govern the peculiarity of the pathological process in the two forms of muscular dystrophy.
