ABSTRACT
Rats were subjected to surfactant-BL inhalations at the early and late phases of bleomycininduced alveolitis. In both regimens, the drug reduced the severity of inflammation. In the acute phase of alveolitis, the therapeutic effect of inhalation was accompanied by activation of the synthesis of fine lose collagen fibrils. In the late phase of alveolitis, inhalation of surfactant-BL thickened the fibrils and diminished their population in alveolar walls.
Subject(s)
Bleomycin/toxicity , Collagen/metabolism , Lung/metabolism , Lung/pathology , Pulmonary Alveoli/metabolism , Pulmonary Alveoli/pathology , Pulmonary Surfactants/toxicity , Animals , Lung/drug effects , Male , Pulmonary Alveoli/drug effects , Rats , Rats, WistarABSTRACT
Rats were exposed to inhalation of surfactant-BL starting from the first or eighth day after intratracheal administration of bleomycin. At the early stages, the preparation effectively attenuated damage to ultrastructural components of the lung tissue and reduced the severity and extent of subsequent pulmonary pathology.
Subject(s)
Lung Injury/drug therapy , Lung/drug effects , Pulmonary Surfactants/administration & dosage , Administration, Inhalation , Animals , Bleomycin/administration & dosage , Cattle , Drug Administration Schedule , Fibrillar Collagens/analysis , Leukocytes/drug effects , Leukocytes/pathology , Lung/pathology , Lung Injury/chemically induced , Lung Injury/pathology , Macrophages/drug effects , Macrophages/pathology , Pulmonary Surfactants/isolation & purification , Rats , Time FactorsABSTRACT
A ten year experience gained in radiotherapy with radio modifiers of 480 patients with cancer of the cervix uteri and of 189 ones with endometrial cancer carried out at the Central Research Roentgeno-Radiological Institute of the Russian Academy of Medical Sciences is analyzed. Local administration of metromidasole with dimethysulfoxide essentially enhanced the detrimental effect of radiation on the tumor. This is reflected in a higher incidence of local control in radiotherapy of patients with cancer of the cervix and corpus uteri. A reduced incidence and degree of radiation injury to organs adjacent to the uterus was observed.