Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 453
Filter
1.
SEMERGEN, Soc. Esp. Med. Rural Gen. (Ed. Impr.) ; 50(3): [102148], Abr. 2024. tab, ilus
Article in Spanish | IBECS | ID: ibc-232211

ABSTRACT

Existe evidencia que demuestra los beneficios de la práctica de actividad física (AF)/ejercicio para la madre después del parto. Sin embargo, este periodo posparto (PP) es, a menudo, una oportunidad perdida en el curso de la vida de las mujeres, para comenzar o reanudar la práctica de ejercicio físico, y obtener los grandes beneficios que esto les puede reportar. El objetivo de este artículo fue analizar los beneficios del ejercicio durante el PP; la prescripción de AF; las recomendaciones sobre el momento de reanudar su práctica; las barreras y facilitadores; el ejercicio físico realizado durante la lactancia materna; así como su papel en las enfermedades y molestias más frecuentes en este periodo, teniendo siempre presente que la labor del médico de atención primaria resulta fundamental para motivar y alentar a las mujeres para que lo practiquen después del parto. (AU)


There is evidence that demonstrates the benefits of practicing physical activity/exercise for the mother after childbirth. However, this postpartum period (PP) is often a missed opportunity in a lifetime for women to start or resume physical exercise and get the great benefits that it can bring them. The objective of this article was to analyze the benefits of physical exercise during PP; the prescription of physical exercise; recommendations on when to resume your practice; barriers and facilitators; physical exercise during breastfeeding; as well as its role in the most frequent illnesses and discomforts in this period, always keeping in mind that the work of the primary care doctor is essential to motivate and encourage women to perform physical exercise in the PP. (AU)


Subject(s)
Humans , Female , Exercise , Gestational Weight Gain , Primary Health Care , Breast Feeding , Physicians
3.
SEMERGEN, Soc. Esp. Med. Rural Gen. (Ed. Impr.) ; 50(1): [e102089], ene.- feb. 2024. tab
Article in Spanish | IBECS | ID: ibc-229441

ABSTRACT

El embarazo es uno de los momentos más importantes y difíciles por los que transcurre una mujer a lo largo de su vida. Supone un periodo de grandes necesidades de macro y micronutrientes para satisfacer las demandas del feto en desarrollo y evitar carencias, para así obtener el mejor resultado posible. Hoy en día, la mayoría de mujeres embarazadas o planeando estarlo conocen la importancia de obtener la cantidad requerida de ciertos tipos de nutrientes (proteínas, grasas, folato, etc.), así como evitar ciertos compuestos (alcohol, tabaco, fármacos, etc.) para evitar posibles complicaciones durante el embarazo. En los últimos años, con la mayor evidencia científica disponible, se ha ido demostrando como algunos de estos nutrientes podrían tener un papel más relevante del que se creía en el resultado óptimo del embarazo, siendo uno de estos nutrientes la colina. La suplementación con colina durante el embarazo ha demostrado ser un tratamiento no farmacológico capaz de mejorar cualidades tanto físicas (crecimiento) como mentales (memoria) del nuevo individuo. La colina se conoce como un nutriente esencial desde 1998 y varios estudios han demostrado su efectividad en modelos de roedores. La existencia de recientes publicaciones que versan sobre su aplicación en humanos hace necesaria la realización de una revisión sistemática. En esta revisión sistemática de la evidencia científica disponible desde el año 2012 hasta la actualidad que versa sobre la aplicación de un mayor consumo de colina mediante suplementación como tratamiento para mejorar los resultados del embarazo, su objetivo principal es determinar los efectos que puede tener en la cognición de los niños una intervención nutricional mediante suplementación de colina en madres embarazadas (AU)


Pregnancy is one of the most important and difficult moments that a woman goes through throughout her life. It is a period of great need for macro and micronutrients to meet the demands of the developing fetus and avoid deficiencies, in order to obtain the best possible result. Nowadays, most women who are pregnant or planning to become pregnant know the importance of getting the required amount of certain types of nutrients (proteins, fats, folate, etc.), as well as avoiding certain compounds (alcohol, tobacco, drugs, etc.) to avoid possible complications during pregnancy. In recent years, with the greatest scientific evidence available, it has been shown how some of these nutrients could have a more relevant role than previously believed in the optimal outcome of pregnancy. One of these nutrients being choline. Choline supplementation during pregnancy has been shown to be a non-pharmacological treatment capable of improving both physical (growth) and mental (memory) qualities of the new individual. Choline has been known as an essential nutrient since 1998 and several studies have shown its effectiveness in rodent models. The existence of recent publications that deal with its application in humans makes it necessary to carry out a systematic review. In this systematic review of the scientific evidence available from 2012 to the present that deals with the application of a higher intake of choline through supplementation as a treatment to improve pregnancy outcomes, its main objetive is to determine the effects that a nutritional intervention through choline supplementation in pregnant mothers can have on children's cognition (AU)


Subject(s)
Humans , Female , Pregnancy , Infant, Newborn , Dietary Supplements , Choline/administration & dosage , Lipotropic Agents/administration & dosage
4.
Semergen ; 50(3): 102148, 2024 Apr.
Article in Spanish | MEDLINE | ID: mdl-38064768

ABSTRACT

There is evidence that demonstrates the benefits of practicing physical activity/exercise for the mother after childbirth. However, this postpartum period (PP) is often a missed opportunity in a lifetime for women to start or resume physical exercise and get the great benefits that it can bring them. The objective of this article was to analyze the benefits of physical exercise during PP; the prescription of physical exercise; recommendations on when to resume your practice; barriers and facilitators; physical exercise during breastfeeding; as well as its role in the most frequent illnesses and discomforts in this period, always keeping in mind that the work of the primary care doctor is essential to motivate and encourage women to perform physical exercise in the PP.


Subject(s)
Exercise , Postpartum Period , Humans , Female , Prescriptions , Primary Health Care
5.
Semergen ; 50(1): 102089, 2024.
Article in Spanish | MEDLINE | ID: mdl-37862810

ABSTRACT

Pregnancy is one of the most important and difficult moments that a woman goes through throughout her life. It is a period of great need for macro and micronutrients to meet the demands of the developing fetus and avoid deficiencies, in order to obtain the best possible result. Nowadays, most women who are pregnant or planning to become pregnant know the importance of getting the required amount of certain types of nutrients (proteins, fats, folate, etc.), as well as avoiding certain compounds (alcohol, tobacco, drugs, etc.) to avoid possible complications during pregnancy. In recent years, with the greatest scientific evidence available, it has been shown how some of these nutrients could have a more relevant role than previously believed in the optimal outcome of pregnancy. One of these nutrients being choline. Choline supplementation during pregnancy has been shown to be a non-pharmacological treatment capable of improving both physical (growth) and mental (memory) qualities of the new individual. Choline has been known as an essential nutrient since 1998 and several studies have shown its effectiveness in rodent models. The existence of recent publications that deal with its application in humans makes it necessary to carry out a systematic review. In this systematic review of the scientific evidence available from 2012 to the present that deals with the application of a higher intake of choline through supplementation as a treatment to improve pregnancy outcomes, its main objetive is to determine the effects that a nutritional intervention through choline supplementation in pregnant mothers can have on children's cognition. For this, 9studies have been analyzed where the treatment given to pregnant women is revealed, this being choline supplementation in different modalities (choline chloride, choline bitartrate, and phosphatidylcholine) and the different effects produced in the children of these mothers who have resulted from these treatment modalities. We conclude by stating that choline supplementation during pregnancy appears to be effective in improving or increasing cognition in children.


Subject(s)
Choline , Dietary Supplements , Child , Female , Humans , Pregnancy , Choline/pharmacology , Choline/therapeutic use , Pregnant Women , Lactation , Micronutrients
6.
Bone ; 174: 116833, 2023 09.
Article in English | MEDLINE | ID: mdl-37385426

ABSTRACT

Skeletal muscle and bone interact at the level of mechanical loading through the application of force by muscles to the skeleton and more recently focus has been placed on molecular/biochemical coupling of these two tissues. We sought to determine if muscle and muscle-derived factors were essential to the osteocyte response to loading. Botox® induced muscle paralysis was used to investigate the role of muscle contraction during in vivo tibia compression loading. 5-6 month-old female TOPGAL mice had their right hindlimb muscles surrounding the tibia injected with either BOTOX® or saline. At four days post injections when muscle paralysis peaked, the right tibia was subjected to a single session of in vivo compression loading at ∼2600 µÎµ. At 24 h post-load we observed a 2.5-fold increase in ß-catenin signaling in osteocytes in the tibias of the saline injected mice, whereas loading of tibias from Botox® injected mice failed to active ß-catenin signaling in osteocytes. This suggests that active muscle contraction produces a factor(s) that is necessary for or conditions the osteocyte's ability to respond to load. To further investigate the role of muscle derived factors, MLO-Y4 osteocyte-like cells and a luciferase based ß-catenin reporter (TOPflash-MLO-Y4) cell line we developed were treated with conditioned media (CM) from C2C12 myoblasts (MB) and myotubes (MT) and ex vivo contracted Extensor Digitorum Longus (EDL) and Soleus (Sol) muscles under static or loading conditions using fluid flow shear stress (FFSS). 10 % C2C12 myotube CM, but not myoblast or NIH3T3 fibroblast cells CM, induced a rapid activation of the Akt signaling pathway, peaking at 15 min and returning to baseline by 1-2 h under static conditions. FFSS applied to MLO-Y4 cells for 2 h in the presence of 10 % MT-CM resulted in a 6-8 fold increase in pAkt compared to a 3-4 fold increase under control or when exposed to 10 % MB-CM. A similar response was observed in the presence of 10 % EDL-CM, but not in the presence of 10 % Sol-CM. TOPflash-MLO-Y4 cells were treated with 10 ng/ml Wnt3a in the presence or absence of MT-CM. While MT-CM resulted in a 2-fold activation and Wnt3a produced a 10-fold activation, the combination of MT-CM + Wnt3a resulted in a 25-fold activation of ß-catenin signaling, implying a synergistic effect of factors in MT-CM with Wnt3a. These data provide clear evidence that specific muscles and myotubes produce factors that alter important signaling pathways involved in the response of osteocytes to mechanical load. These data strongly suggest that beyond mechanical loading there is a molecular coupling of muscle and bone.


Subject(s)
Botulinum Toxins, Type A , Osteocytes , Female , Animals , Mice , Osteocytes/metabolism , Proto-Oncogene Proteins c-akt/metabolism , Phosphatidylinositol 3-Kinases/metabolism , beta Catenin/metabolism , Botulinum Toxins, Type A/metabolism , Botulinum Toxins, Type A/pharmacology , NIH 3T3 Cells , Muscle, Skeletal/metabolism , Paralysis/metabolism
7.
Rev. esp. med. nucl. imagen mol. (Ed. impr.) ; 42(1): 33-37, ene.-feb. 2023. tab
Article in Spanish | IBECS | ID: ibc-214746

ABSTRACT

El cáncer diferenciado de tiroides (CDT) representa la neoplasia endocrina más frecuente, registrándose un incremento en las últimas décadas. El carcinoma papilar es el subtipo histológico más frecuente y un gran número de casos se relaciona con tumores de pequeño tamaño y con poca repercusión clínica, detectados de manera incidental o como consecuencia de la disponibilidad de las técnicas diagnósticas. El «buen pronóstico» de la mayoría de los casos han mantenido desde hace años la controversia en el abordaje de estos pacientes, especialmente en dos aspectos básicos del protocolo terapéutico: la cirugía y la administración de radioyodo. Si bien en los pacientes metastásicos y de alto riesgo, la administración de terapia con 131I está ampliamente aceptada, en los pacientes de riesgo intermedio-bajo su uso está muy cuestionado. En este trabajo realizamos una revisión de la evidencia disponible sobre la terapia con radioyodo en los pacientes de bajo riesgo (AU)


Differentiated thyroid cancer (DTC) is the most frequent endocrine neoplasm, with an incidence that has increased in recent decades. Papillary carcinoma is the most frequent histological subtype and a large number of cases are related to tumors of small size and with little clinical repercussion that are detected incidentally or as a consequence of the availability of diagnostic techniques. Due to the “good prognosis” of the majority of cases, for years the approach to these patients has remained controversial, especially in relation to two basic aspects of the therapeutic protocol: surgery and the administration of radioiodine. While in metastatic and high-risk patients, the administration of 131I therapy is widely accepted, in intermediate-low risk patients its use is highly questioned. Here we review the available evidence on radioiodine therapy in low-risk patients (AU)


Subject(s)
Humans , Iodine Radioisotopes/therapeutic use , Thyroid Neoplasms/radiotherapy , Prognosis
9.
AJNR Am J Neuroradiol ; 43(9): 1350-1355, 2022 09.
Article in English | MEDLINE | ID: mdl-36574323

ABSTRACT

PURPOSE: To determine the accuracy of MR imaging for diagnosis of meningitis in infants. MATERIALS AND METHODS: Retrospective review of infants less than 1 year of age who underwent a brain MR imaging for meningitis from 2010-2018. Gold standard for diagnosis of bacterial meningitis was a positive bacterial CSF culture or a positive blood culture with an elevated CSF WBC count, and diagnosis of viral meningitis was a positive CSF PCR result and elevated CSF WBC count. Sensitivity, specificity, PPV, NPV, and accuracy for MR imaging diagnosis of meningitis were calculated. RESULTS: Two hundred nine infants with mean age 80 days (range 0-347 days) were included. There were 178 true positives with the most common pathogens being: Group B Streptococcus (58), E. coli (50), Streptococcus pneumoniae (21), H. influenzae (4); Herpes simplex virus 1 or 2 (18); Enterovirus (4); and other (23). There were 31 true negatives. Range of sensitivity, specificity, PPV, NPV, and accuracy of MR imaging for detection of meningitis was 67.4-83.5%, 92.3-95.7%, 95.0-98.6%, 33.3-76.5%, and 71.3-86.5% respectively. MR imaging sensitivity decreased after 10 days from time of presentation while specificity remained stable. Among individual MR imaging findings, leptomeningeal enhancement was the most sensitive finding, while cerebritis, infarction, ventriculitis, abscess, and intraventricular purulent material were the most specific findings. CONCLUSIONS: MR imaging of the brain demonstrates high specificity and moderate sensitivity for diagnosis among infants presenting with signs and symptoms of meningitis. The results reflect current standard of care for imaging of infants with meningitis however a selection bias for imaging of more severe meningitis may affect these results.


Subject(s)
Encephalitis , Meningitis, Bacterial , Infant , Humans , Escherichia coli , Meningitis, Bacterial/diagnostic imaging , Streptococcus pneumoniae , Streptococcus agalactiae , Magnetic Resonance Imaging , Sensitivity and Specificity
10.
SEMERGEN, Soc. Esp. Med. Rural Gen. (Ed. Impr.) ; 48(6): 423-430, sept, 2022. tab
Article in Spanish | IBECS | ID: ibc-211027

ABSTRACT

La actividad física durante el embarazo promueve la salud materna, fetal y neonatal. Los beneficios para la salud de la actividad física prenatal incluyen un riesgo reducido de aumento de peso gestacional excesivo, diabetes gestacional, preeclampsia, complicaciones del parto, parto prematuro, complicaciones del recién nacido y depresión posparto. Las principales guías de actividad física/ejercicio durante el embarazo recomiendan que todas las mujeres embarazadas sin contraindicaciones médicas u obstétricas se mantengan activas físicamente durante la gestación, con el objetivo de conseguir beneficios para su salud y, al mismo tiempo, reducir la posibilidad de complicaciones durante el embarazo. Analizamos en este artículo lo que la medicina basada en la evidencia (MBE) indica con respecto al ejercicio físico y el embarazo. Para ello, nos basamos en las diferentes Revisiones Cochrane existentes, así como en las principales Guías de práctica clínica y Documentos de consenso (AU)


Physical activity during pregnancy promotes maternal, fetal and neonatal health. The health benefits of prenatal physical activity include a reduced risk of excess gestational weight gain, gestational diabetes, preeclampsia, labor complications, preterm labor, newborn complications, and postpartum depression. The main guidelines for physical activity/exercise during pregnancy recommend that all pregnant women without medical or obstetric contraindications, remain physically active during the gestation, in order to achieve benefits for their health and at the same time reduce the possibility of complications during pregnancy. We analyze in this article what evidence based medicine (EBM) indicates regarding physical exercise and pregnancy. To do this, we draw on the different existing Cochrane reviews, as well as on the main Clinical practice guidelines and Consensus documents (AU)


Subject(s)
Humans , Female , Pregnancy , Evidence-Based Medicine , Pregnancy Complications/prevention & control , Exercise
11.
Rev. esp. cir. ortop. traumatol. (Ed. impr.) ; 66(4): 267-273, Jul - Ago 2022. tab, graf
Article in Spanish | IBECS | ID: ibc-204995

ABSTRACT

Introducción: La mejoría de la esperanza de vida está incrementando la incidencia de fractura de cadera en centenarios. Nuestro objetivo es comparar las características basales de una serie de centenarios con fractura de cadera frente a controles de menor edad, analizando si existen diferencias en cuanto a complicaciones, mortalidad intrahospitalaria y supervivencia a corto-medio plazo. Material y métodos: Estudio retrospectivo, tipo caso control, sobre 24 centenarios y 48 controles octogenarios con fractura de cadera. Se analizó la presencia de comorbilidades y el índice de Charlson, la demora quirúrgica, las complicaciones, la estancia hospitalaria y la mortalidad durante el ingreso. Al alta se valoró la mortalidad precoz, la supervivencia después del año y el retorno a la funcionalidad previa. Resultados: No se encontraron diferencias significativas en parámetros basales ni en comorbilidades (p>0,05), siendo el paciente tipo una mujer con fractura extracapsular. La estancia hospitalaria fue mayor en el grupo control (p=0,038) y la complicación más frecuente la anemia, que precisó transfusión sanguínea (23/24 en los centenarios, p<0,0001). La mortalidad intrahospitalaria y acumulada al año en los centenarios fue del 33 y el 67%, respectivamente, frente al 10 y 25% en octogenarios (p=0,017, OR=4,3 [1,224-15,101] y p=0,110]. Solo 2 pacientes centenarios consiguieron volver a caminar tras la intervención, frente a un 53,84% que volvió a la situación funcional previa en los controles (p=0,003). Conclusiones: Frente a un grupo control de pacientes de menor edad, la mortalidad intrahospitalaria y en el primer año tras una fractura de cadera es significativamente mayor en los centenarios y muy pocos recuperan la actividad previa a la fractura.(AU)


Introduction: Hip fractures in centenarians are rising due to the increase in life expectancy. The objective of this study is to compare the characteristics of centenarians’ hip fracture with a younger control group, and to analyze whether there are differences in terms of in-hospital mortality, complications, and short-medium-term survival between them. Material and methods: Retrospective case-control study, with a series of 24 centenarians and 48 octogenarians with a hip fracture. Comorbidities and Charlson index, surgical delay, complications and mortality during admission, and hospital stay were analyzed. At discharge, early mortality, survival after one year, and return to previous functionality were assessed. Results: No significant differences were found in baseline parameters or comorbidities (P>.05), and the type of was a woman with an extracapsular fracture. Hospital stay was longer in the control group (P=.038), and the most frequent complication was anemia requiring transfusion (23/24 in centenarians, P<.0001). In-hospital mortality and accumulated at one year in the centenarians was 33 and 67%, respectively, compared to 10 and 25% in the octogenarians (P=.017, OR=4.3 [1,224-15,101] and P=.110). Only 2 centenarian patients were able to walk again after the intervention, while in the control group 53.84% returned to the previous functional situation (P=.003). Conclusions: Compared to a control group of younger patients, in-hospital mortality and in the first year after a hip fracture is significantly higher in centenarians, and very few recover activity prior to the fracture.(AU)


Subject(s)
Humans , Male , Female , Aged, 80 and over , Hip Fractures/surgery , Hip Fractures/mortality , Aged, 80 and over , Life Expectancy , Comorbidity , Hip Fractures/complications , Length of Stay , Retrospective Studies , Orthopedics , Traumatology
12.
Rev. esp. cir. ortop. traumatol. (Ed. impr.) ; 66(4): T267-T273, Jul - Ago 2022. tab, graf
Article in English | IBECS | ID: ibc-204996

ABSTRACT

Introduction: Hip fractures in centenarians are rising due to the increase in life expectancy. The objective of this study is to compare the characteristics of centenarians’ hip fracture with a younger control group, and to analyze whether there are differences in terms of in-hospital mortality, complications, and short-medium-term survival between them. Material and methods: Retrospective case-control study, with a series of 24 centenarians and 48 octogenarians with a hip fracture. Comorbidities and Charlson index, surgical delay, complications and mortality during admission, and hospital stay were analyzed. At discharge, early mortality, survival after one year, and return to previous functionality were assessed. Results: No significant differences were found in baseline parameters or comorbidities (P>.05), and the type of was a woman with an extracapsular fracture. Hospital stay was longer in the control group (P=.038), and the most frequent complication was anemia requiring transfusion (23/24 in centenarians, P<.0001). In-hospital mortality and accumulated at one year in the centenarians was 33 and 67%, respectively, compared to 10 and 25% in the octogenarians (P=.017, OR=4.3 [1,224-15,101] and P=.110). Only 2 centenarian patients were able to walk again after the intervention, while in the control group 53.84% returned to the previous functional situation (P=.003). Conclusions: Compared to a control group of younger patients, in-hospital mortality and in the first year after a hip fracture is significantly higher in centenarians, and very few recover activity prior to the fracture.(AU)


Introducción: La mejoría de la esperanza de vida está incrementando la incidencia de fractura de cadera en centenarios. Nuestro objetivo es comparar las características basales de una serie de centenarios con fractura de cadera frente a controles de menor edad, analizando si existen diferencias en cuanto a complicaciones, mortalidad intrahospitalaria y supervivencia a corto-medio plazo. Material y métodos: Estudio retrospectivo, tipo caso control, sobre 24 centenarios y 48 controles octogenarios con fractura de cadera. Se analizó la presencia de comorbilidades y el índice de Charlson, la demora quirúrgica, las complicaciones, la estancia hospitalaria y la mortalidad durante el ingreso. Al alta se valoró la mortalidad precoz, la supervivencia después del año y el retorno a la funcionalidad previa. Resultados: No se encontraron diferencias significativas en parámetros basales ni en comorbilidades (p>0,05), siendo el paciente tipo una mujer con fractura extracapsular. La estancia hospitalaria fue mayor en el grupo control (p=0,038) y la complicación más frecuente la anemia, que precisó transfusión sanguínea (23/24 en los centenarios, p<0,0001). La mortalidad intrahospitalaria y acumulada al año en los centenarios fue del 33 y el 67%, respectivamente, frente al 10 y 25% en octogenarios (p=0,017, OR=4,3 [1,224-15,101] y p=0,110]. Solo 2 pacientes centenarios consiguieron volver a caminar tras la intervención, frente a un 53,84% que volvió a la situación funcional previa en los controles (p=0,003). Conclusiones: Frente a un grupo control de pacientes de menor edad, la mortalidad intrahospitalaria y en el primer año tras una fractura de cadera es significativamente mayor en los centenarios y muy pocos recuperan la actividad previa a la fractura.(AU)


Subject(s)
Humans , Male , Female , Aged, 80 and over , Hip Fractures/surgery , Hip Fractures/mortality , Aged, 80 and over , Life Expectancy , Comorbidity , Hip Fractures/complications , Length of Stay , Retrospective Studies , Orthopedics , Traumatology
13.
Semergen ; 48(6): 423-430, 2022 Sep.
Article in Spanish | MEDLINE | ID: mdl-35527186

ABSTRACT

Physical activity during pregnancy promotes maternal, fetal and neonatal health. The health benefits of prenatal physical activity include a reduced risk of excess gestational weight gain, gestational diabetes, preeclampsia, labor complications, preterm labor, newborn complications, and postpartum depression. The main guidelines for physical activity/exercise during pregnancy recommend that all pregnant women without medical or obstetric contraindications, remain physically active during the gestation, in order to achieve benefits for their health and at the same time reduce the possibility of complications during pregnancy. We analyze in this article what evidence based medicine (EBM) indicates regarding physical exercise and pregnancy. To do this, we draw on the different existing Cochrane reviews, as well as on the main Clinical practice guidelines and Consensus documents.


Subject(s)
Exercise , Pregnancy Complications , Evidence-Based Medicine , Female , Humans , Infant, Newborn , Pregnancy , Pregnancy Complications/therapy
14.
Exp Eye Res ; 219: 109019, 2022 06.
Article in English | MEDLINE | ID: mdl-35263654

ABSTRACT

PURPOSE: Retinitis pigmentosa (RP) patients commonly experience negative psychological states due to their progressive and unpredictable loss of vision and visual variations related to stress. The aim of this study was to examine hair cortisol concentrations (HCCs), which is usually associated with chronic stress, pretending to unveil possible associations between underlying psychological factors and disease severity in RP patients. METHODS: Seventy-eight RP patients and 148 healthy controls were included in this study. A complete ophthalmological exam was performed in all patients to grade into severity disease groups. Perceived stress and trait-anxiety were measured by the State-Trait Anxiety Inventory (STAI) questionnaire. RESULTS: Fifty-two (67%) patients had severe RP and 26 (33%) mild-moderate RP. Fifty-eight (58,9%) patients reported severely levels of stress and 18 (23.,1%) highly levels assessed by STAI questionnaire. RP patients exhibited higher HCCs (500.04 ± 120.99 pg/mg) than in controls (136.17 ± 60.51 pg/mg; p < 0.001). Severe RP patients had significant higher HCCs than mild-moderate patients differing in 274.27 pg/mg (p < 0.001). RP severity grade and perceived anxiety levels in the questionaries were not associated. Group differences were not affected by relevant covariates (age, grade of severity, stress status, and gender). CONCLUSIONS: HCC seems an effective biomarker associated with chronic stress in RP patients. This study shows that HCC in patients with RP are elevated compared to population-based controls, and association between HCC and RP severity was found. Future research is needed to characterize the effect of untreated negative psychological states on progression of the disease if any.


Subject(s)
Hydrocortisone , Retinitis Pigmentosa , Biomarkers , Hair , Humans , Retinitis Pigmentosa/diagnosis , Surveys and Questionnaires
17.
Rev. esp. cir. ortop. traumatol. (Ed. impr.) ; 66(1): T52-T59, Ene-Feb 2022. ilus, tab
Article in English | IBECS | ID: ibc-204933

ABSTRACT

Introduction: Life expectancy has risen, leading to an increase in acetabular fractures in fragile patients. Total hip arthroplasty with a reinforcement cage is a technically complex option, but allows fracture control and early mobilization. Our aim is to assess whether the use of Burch-Schneider cage in fragile patients with acetabular fractures allows immediate load stabilization without threatening the early survival of the arthroplasty. Material and methods: Descriptive study of a series of 14 patients with acetabular fractures treated by a reinforcement cage associated with autologous bonegraft plus a cemented acetabular cup, and mobilization and bearing. Judet Letournel fracture types, surgical delay, and complications during admission were analyzed. Following hospital discharge we recorded the incorporation of grafts according to Gie's classification, presence of calcifications according to Brooker, consolidation of the fracture, loosening of implants and functional aspects according to the HHS and Merlé D’Aubigné Postel score. Results: The most common fracture was both columns (6/14), with a surgical delay being of 11 days mean and 21,5 days of length of stay. One patient died after surgery. The mean follow-up was 34.4 months. All fractures healed and the bonegraft was incorporated in all cases. The mean HHS was 82 points and the Merle Score was 15/18. There were no complications related to arthroplasty. Conclusions: Total hip arthroplasty with Burch-Schneider cage on bonegraft and no added osteosynthesis is a good option of treatment of all types of displaced acetabular fractures in a fragile patient.(AU)


Introducción: El aumento de esperanza de vida está produciendo un incremento de fracturas de cotilo en el paciente anciano. La artroplastia total con anillo de refuerzo es una opción técnicamente compleja, pero permite el control de la fractura, la movilización y la deambulación precoz. Nuestro objetivo es valorar si el uso del anillo de Burch-Schneider en las fracturas de cotilo del paciente anciano permite la estabilización sin poner en riesgo la supervivencia precoz de la artroplastia. Material y métodos: Estudio descriptivo sobre una serie de 14 pacientes con fracturas de cotilo tratados mediante anillo de refuerzo asociado a autoinjerto más implante acetabular cementado e inicio precoz de movilización y deambulación. Se analizaron los tipos de fractura según la clasificación de Judet Letournel, la demora quirúrgica y las complicaciones durante el ingreso. Al alta se valoró la incorporación de injertos según la clasificación de Gie, la presencia de calcificaciones según Brooker, la consolidación de la fractura, la movilización de implantes y los aspectos funcionales según la escala de HHS y Merlé D’Aubigné Postel. Resultados: La fractura más frecuente fue la de ambas columnas (6/14), la demora quirúrgica media de 11 días y la estancia media de 21,5 días. Un paciente falleció en el postoperatorio inmediato. El seguimiento medio fue de 34,4 meses. Todas las fracturas consolidaron e incorporaron el injerto. El HHS medio fue de 82 puntos y el Merle Score de 15/18. No hubo complicaciones relativas a la artroplastia. Conclusiones: La artroplastia primaria de cadera con anillo de BS sobre injerto sin osteosíntesis añadida es una buena opción en el tratamiento de todo tipo de fracturas de cotilo desplazadas en paciente frágil.(AU)


Subject(s)
Middle Aged , Aged , Aged, 80 and over , Arthroplasty, Replacement, Hip , Acetabulum/injuries , Acetabulum/surgery , Autografts , Walking , Epidemiology, Descriptive , Traumatology , Orthopedics
18.
Rev. esp. cir. ortop. traumatol. (Ed. impr.) ; 66(1): 52-59, Ene-Feb 2022. ilus, tab
Article in Spanish | IBECS | ID: ibc-204934

ABSTRACT

Introducción: El aumento de esperanza de vida está produciendo un incremento de fracturas de cotilo en el paciente anciano. La artroplastia total con anillo de refuerzo es una opción técnicamente compleja, pero permite el control de la fractura, la movilización y la deambulación precoz. Nuestro objetivo es valorar si el uso del anillo de Burch-Schneider en las fracturas de cotilo del paciente anciano permite la estabilización sin poner en riesgo la supervivencia precoz de la artroplastia. Material y métodos: Estudio descriptivo sobre una serie de 14 pacientes con fracturas de cotilo tratados mediante anillo de refuerzo asociado a autoinjerto más implante acetabular cementado e inicio precoz de movilización y deambulación. Se analizaron los tipos de fractura según la clasificación de Judet Letournel, la demora quirúrgica y las complicaciones durante el ingreso. Al alta se valoró la incorporación de injertos según la clasificación de Gie, la presencia de calcificaciones según Brooker, la consolidación de la fractura, la movilización de implantes y los aspectos funcionales según la escala de HHS y Merlé D’Aubigné Postel. Resultados: La fractura más frecuente fue la de ambas columnas (6/14), la demora quirúrgica media de 11 días y la estancia media de 21,5 días. Un paciente falleció en el postoperatorio inmediato. El seguimiento medio fue de 34,4 meses. Todas las fracturas consolidaron e incorporaron el injerto. El HHS medio fue de 82 puntos y el Merle Score de 15/18. No hubo complicaciones relativas a la artroplastia. Conclusiones: La artroplastia primaria de cadera con anillo de BS sobre injerto sin osteosíntesis añadida es una buena opción en el tratamiento de todo tipo de fracturas de cotilo desplazadas en paciente frágil.(AU)


Introduction: Life expectancy has risen, leading to an increase in acetabular fractures in fragile patients. Total hip arthroplasty with a reinforcement cage is a technically complex option, but allows fracture control and early mobilization. Our aim is to assess whether the use of Burch-Schneider cage in fragile patients with acetabular fractures allows immediate load stabilization without threatening the early survival of the arthroplasty. Material and methods: Descriptive study of a series of 14 patients with acetabular fractures treated by a reinforcement cage associated with autologous bonegraft plus a cemented acetabular cup, and mobilization and bearing. Judet Letournel fracture types, surgical delay, and complications during admission were analyzed. Following hospital discharge we recorded the incorporation of grafts according to Gie's classification, presence of calcifications according to Brooker, consolidation of the fracture, loosening of implants and functional aspects according to the HHS and Merlé D’Aubigné Postel score. Results: The most common fracture was both columns (6/14), with a surgical delay being of 11 days mean and 21,5 days of length of stay. One patient died after surgery. The mean follow-up was 34.4 months. All fractures healed and the bonegraft was incorporated in all cases. The mean HHS was 82 points and the Merle Score was 15/18. There were no complications related to arthroplasty. Conclusions: Total hip arthroplasty with Burch-Schneider cage on bonegraft and no added osteosynthesis is a good option of treatment of all types of displaced acetabular fractures in a fragile patient.(AU)


Subject(s)
Humans , Male , Female , Middle Aged , Aged , Aged, 80 and over , Arthroplasty, Replacement, Hip , Acetabulum/injuries , Acetabulum/surgery , Autografts , Walking , Epidemiology, Descriptive , Traumatology , Orthopedics
19.
Rev Esp Cir Ortop Traumatol ; 66(4): 267-273, 2022.
Article in English, Spanish | MEDLINE | ID: mdl-34344619

ABSTRACT

INTRODUCTION: Hip fractures in centenarians are rising due to the increase in life expectancy. The objective of this study is to compare the characteristics of centenarians' hip fracture with a younger control group, and to analyze whether there are differences in terms of in-hospital mortality, complications, and short-medium-term survival between them. MATERIAL AND METHODS: Retrospective case-control study, with a series of 24 centenarians and 48 octogenarians with a hip fracture. Comorbidities and Charlson index, surgical delay, complications and mortality during admission, and hospital stay were analyzed. At discharge, early mortality, survival after one year, and return to previous functionality were assessed. RESULTS: No significant differences were found in baseline parameters or comorbidities (P>.05), and the type of was a woman with an extracapsular fracture. Hospital stay was longer in the control group (P=.038), and the most frequent complication was anemia requiring transfusion (23/24 in centenarians, P<.0001). In-hospital mortality and accumulated at one year in the centenarians was 33 and 67%, respectively, compared to 10 and 25% in the octogenarians (P=.017, OR=4.3 [1,224-15,101] and P=.110). Only 2 centenarian patients were able to walk again after the intervention, while in the control group 53.84% returned to the previous functional situation (P=.003). CONCLUSIONS: Compared to a control group of younger patients, in-hospital mortality and in the first year after a hip fracture is significantly higher in centenarians, and very few recover activity prior to the fracture.

20.
Rev Esp Cir Ortop Traumatol ; 66(1): 52-59, 2022.
Article in English, Spanish | MEDLINE | ID: mdl-34130928

ABSTRACT

INTRODUCTION: Life expectancy has risen, leading to an increase in acetabular fractures in fragile patients. Total hip arthroplasty with a reinforcement cage is a technically complex option, but allows fracture control and early mobilization. Our aim is to assess whether the use of Burch-Schneider cage in fragile patients with acetabular fractures allows immediate load stabilization without threatening the early survival of the arthroplasty. MATERIAL AND METHODS: Descriptive study of a series of 14 patients with acetabular fractures treated by a reinforcement cage associated with autologous bonegraft plus a cemented acetabular cup, and mobilization and bearing. Judet Letournel fracture types, surgical delay, and complications during admission were analyzed. Following hospital discharge we recorded the incorporation of grafts according to Gie's classification, presence of calcifications according to Brooker, consolidation of the fracture, loosening of implants and functional aspects according to the HHS and Merlé D'Aubigné Postel score. RESULTS: The most common fracture was both columns (6/14), with a surgical delay being of 11 days mean and 21,5 days of length of stay. One patient died after surgery. The mean follow-up was 34.4 months. All fractures healed and the bonegraft was incorporated in all cases. The mean HHS was 82 points and the Merle Score was 15/18. There were no complications related to arthroplasty. CONCLUSIONS: Total hip arthroplasty with Burch-Schneider cage on bonegraft and no added osteosynthesis is a good option of treatment of all types of displaced acetabular fractures in a fragile patient.

SELECTION OF CITATIONS
SEARCH DETAIL
...