ABSTRACT
Blood lead levels (PbB), delta-ALA dehydratase activity (ALAD) and erythrocytic protoporphyrin (EPP) values were studied in heavy wine and spirit drinkers. Results were compared in both groups and with a control group (teetotalers). Results in all cases are expressed as arithmetic means +/- SD. PbB values found in the three groups were statistically different inter se: wine group, 195 +/- 82 microg l(-1); spirits group, 159 +/- 69 microg l(-1); teetotalers, 72 +/- 43 microg l(-1). ALAD was significantly lower in the drinker groups (wine 26.9 plus minus 11.4 U l(-1)and spirits 28.3 plus minus 11.6 U l(-1))vs the control group (48.3 plus minus 13.5 U l(-1)). Differences in EPP levels in the three groups were only significant between the teetotaler and the wine drinker groups. Our findings indicate that, in heavy drinkers (more than 2 liters of wine per day), not only are lead levels increased in the blood but there are also biochemical alterations that affect the heme biosynthetic pathway, which should be taken into account in treatment for alcoholics.
Subject(s)
Alcohol Drinking/adverse effects , Lead/blood , Porphobilinogen Synthase/metabolism , Protoporphyrins/metabolism , Alcoholic Beverages/adverse effects , Erythrocytes/drug effects , Erythrocytes/metabolism , Humans , MaleABSTRACT
En 207 ninos contaminados por via percutanea con acetato de fenilmercurio por contacto con panales procesados en lavanderias, se realizaron como estudio de rutina radiografias de metafisis de rodillas y munecas observandose en 116 de ellos (56%) lineas de detencion del crecimiento de Park. La frecuencia de esta observacion sugiere que la exposicion repetida al mercurio condiciona episodios de detencion del crecimiento oseo seguidos de etapas de normalizacion
Subject(s)
Infant, Newborn , Infant , Child, Preschool , Humans , Comparative Study , Growth Disorders , Bone Diseases, Developmental , Mercury Poisoning , RadiographyABSTRACT
En 207 ninos contaminados por via percutanea con acetato de fenilmercurio por contacto con panales procesados en lavanderias, se realizaron como estudio de rutina radiografias de metafisis de rodillas y munecas observandose en 116 de ellos (56%) lineas de detencion del crecimiento de Park. La frecuencia de esta observacion sugiere que la exposicion repetida al mercurio condiciona episodios de detencion del crecimiento oseo seguidos de etapas de normalizacion
