Search | VHL Regional Portal

Lung hypoplasia and surfactant system immaturity induced in the fetal rat by prenatal exposure to nitrofen.

Alfanso, L F; Arnaiz, A; Alvarez, F J; Qi, B; Diez-Pardo, J A; Vallis-i-Soler, A; Tovar, J A.

Biol Neonate ; 69(2): 94-100, 1996.

Article in English | MEDLINE | ID: mdl-8713654

ABSTRACT

We studied the biochemical maturity of the lungs of fetuses born to rats exposed to nitrofen on day 9.5 of gestation. In comparison with controls, nitrofen-treated fetuses had pulmonary hypoplasia (decreased lung/body weight), lung hypocellularity (low DNA content) and cellular atrophy (low protein/DNA and phospholipid/DNA) on gestational days 19 and 21. Treated animals with congenital diaphragmatic hernia (CDH) also had cell atrophy and surfactant immaturity (decreased disaturated phosphatidylcholine/DNA) near term. Our data demonstrate that nitrofen causes lung hypoplasia and some degree of surfactant system immaturity that is particularly prominent in fetuses with CDH.

Subject(s)

Lung/drug effects , Phenyl Ethers/toxicity , Prenatal Exposure Delayed Effects , Pulmonary Surfactants/metabolism , Animals , Female , Hernias, Diaphragmatic, Congenital , Lung/abnormalities , Lung/embryology , Male , Phosphatidylcholines/metabolism , Phospholipids/metabolism , Pregnancy , Rats , Rats, Wistar

Necrotising entercolitis. Increased incidence in infants receiving nasoduodenal feeding.

Vazquez, C; Arroyos, A; Vallis I Soler, A.

Arch Dis Child ; 55(10): 826, 1980 Oct.

Article in English | MEDLINE | ID: mdl-6776900

Subject(s)

Carbamoyl-Phosphate Synthase (Ammonia)/deficiency , Enteral Nutrition/adverse effects , Enterocolitis, Pseudomembranous/etiology , Infant, Newborn, Diseases/etiology , Ligases/deficiency , Carbamoyl-Phosphate Synthase (Ammonia)/analysis , Humans , Infant , Infant, Newborn

ABSTRACT

Subject(s)

Subject(s)

SEND TO:

SELECTION OF CITATIONS

SEARCH DETAIL