ABSTRACT
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Subject(s)
Humans , Male , Adolescent , Toxocariasis/diagnosis , Eye Infections, Parasitic/diagnosis , Toxocariasis/drug therapy , Toxocariasis/microbiology , Eye Infections, Parasitic/pathology , Albendazole/therapeutic use , Anthelmintics/therapeutic use , Adrenal Cortex Hormones/therapeutic useSubject(s)
Anemia, Aplastic/therapy , Bone Marrow Transplantation , Eye Infections, Parasitic/diagnosis , Toxocara canis/immunology , Toxocariasis/diagnosis , Adolescent , Adrenal Cortex Hormones/therapeutic use , Albendazole/therapeutic use , Anemia, Aplastic/complications , Animals , Anthelmintics/therapeutic use , Antibodies, Helminth/blood , Dogs/parasitology , Drug Therapy, Combination , Emergencies , Eye Infections, Parasitic/blood , Eye Infections, Parasitic/complications , Humans , Immunocompromised Host , Immunosuppressive Agents/adverse effects , Immunosuppressive Agents/therapeutic use , Male , Socioeconomic Factors , Toxocariasis/blood , Toxocariasis/complications , Toxocariasis/drug therapyABSTRACT
PURPOSE: To compare myopia progression in children randomized to MiSight contact lenses (CLs) versus children corrected with single-vision spectacles (SV) over a 2-year period. METHODS: Subjects aged 8 to 12 with myopia (-0.75 to -4.00 D sphere) and astigmatism (< -1.00 D cylinder) were assigned to the lens study group (MiSight) or the control group (single vision). Measurements of visual acuity and subjective refraction were taken at 6-month intervals, and axial length, anterior chamber, corneal power, and cycloplegic autorefraction were measured at the baseline, 12-month, and 24-month visits. RESULTS: Eighty-nine subjects were recruited. Forty-fix children were assigned to the MiSight group, and 33 to the single-vision spectacle group. In total, 74 children completed the clinical trial, with the following parameters at the beginning of the study: n = 41 in the MiSight group (age: 11.01 ± 1.23 years, spherical equivalent: -2.16 ± 0.94 D, gender: male: 21, female: 20) and n = 33 in the single-vision group (age: 10.12 ± 1.38 years, spherical equivalent: -1.75 ± 0.94 D, gender: male: 12, female: 21). After 2 years of follow-up, myopia progressed slowly in the MiSight group compared to the control group (0.45 D vs 0.74 D, p < 0.001) and there was less axial elongation in the MiSight group compared to the single-vision group (0.28 mm vs 0.44 mm, p < 0.001). Therefore, use of MiSight CLs produced lower myopia progression (39.32%) and lower axial growth of the eye (36.04%) at 2 years compared to spectacle use. CONCLUSIONS: MiSight contact lens wear reduces axial elongation and myopia progression in comparison to distance single-vision spectacles in children. ClinicalTrials.gov Identifier: NCT01917110.
