ABSTRACT
The epidermal growth factor receptor (EGFR) antagonist, cetuximab, has recently been shown to enhance the effects of radiotherapy, and reports to date indicate that this effect occurs without any change in the pattern and severity of toxicity usually associated with head and neck radiation and/or chemotherapy (CT) administration. Moreover, several studies have reported that the expression of EGFR is strongly linked to poor outcome in patients undergoing therapy. Therefore, the presence of the EGFR in almost all cases of head and neck carcinoma offers a new therapeutic opportunity to most patients. In this paper, we report a review of the major studies dealing with the use of cetuximab in advanced head and neck cancer.
Subject(s)
Antibodies, Monoclonal/therapeutic use , Antineoplastic Agents/therapeutic use , Carcinoma, Squamous Cell/drug therapy , Head and Neck Neoplasms/drug therapy , Animals , Antibodies, Monoclonal, Humanized , Carcinoma, Squamous Cell/radiotherapy , Carcinoma, Squamous Cell/secondary , Cetuximab , Clinical Trials, Phase I as Topic , Clinical Trials, Phase II as Topic , Head and Neck Neoplasms/pathology , Head and Neck Neoplasms/radiotherapy , Humans , Neoplasm Recurrence, Local , Radiation-Sensitizing Agents/therapeutic useABSTRACT
A multicenter randomized study comparing high dose of mitomycin and epirubicin given as hepatic intra-arterial chemotherapy (HIAC) combined with caval chemofiltration (CF) versus low doses of the same drugs in unresectable liver metastases from colorectal cancer showed a significant improvement in the survival rate of the 20 patients treated with high dose compared to the 22 patients treated with low doses with a 1 year survival of 69% vs 39%. The median survival was 17 vs 11 months and the responses were 65% vs 33%. Toxicity was colangitis in 50% of patients considered. The extrahepatic progression was similar in the two groups (7/20 vs 8/22).
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/administration & dosage , Colorectal Neoplasms/pathology , Infusions, Intra-Arterial/methods , Liver Neoplasms/drug therapy , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Epirubicin/administration & dosage , Filtration , Humans , Liver Neoplasms/mortality , Liver Neoplasms/secondary , Mitomycin/administration & dosage , Prospective Studies , Survival RateSubject(s)
Antigens, Surface/analysis , Leukemia, Myeloid, Acute/classification , Acute Disease , Adolescent , Adult , Aged , Child , Child, Preschool , Female , France , Humans , Leukemia/classification , Male , Middle Aged , Phenotype , United Kingdom , United StatesABSTRACT
Isoelectrofocusing was carried out in the LKB Multiphor apparatus with pH 4-6.5 carrier ampholines using polyacrylamide gel slabs. Specimens of purified antithrombin III (AT-III), normal plasma and serum were isoelectrofocused. Microheterogeneity was shown by three preparations of purified AT; the protein was separated in at least six bands, three large bands were located in the pH range 4.9-5.2, one intermediate band at pH 4.85, other thinner bands were located in the pH range 4.55-4.80. The microheterogeneity of AT-III was confirmed in purified preparations as well as in plasma and in serum by crossed immunoelectrofocusing. The pattern of purified preparations, normal plasma and serum were very similar; only minor, quantitative differences were noticed. Plasma from a patient with congenital AT-III deficiency showed an abnormal pattern.
Subject(s)
Antithrombin III , Humans , Immunoelectrophoresis, Two-Dimensional , Isoelectric FocusingABSTRACT
The behaviour of the factor VIII/von Willebrand factor complex (VIII:C, VIIIR:Ag and VIIIR:RCof) was investigated in 23 patients with secretory myeloma, in 2 patients with non-secretory myeloma and in 5 patients with macroglobulinemia. In most patients (21 of 25 patients with plasma cell myeloma and 2 of 5 patients with macroglobulinemia) VIIIR:Ag was increased usually without corresponding increases in VIII:C and VIIIR:RCof. There was no correlation between the VIIIR:Ag levels and paraprotein Ig type or level nor with the presence or the absence of Bence Jones proteins in serum and urine. Furthermore, increased levels of VIIIR:Ag were found in patients with non-secretory myeloma. In general, VIIIR:Ag was higher in patients with extensive bone lesions and there was a significant correlation between cell mass and the VIIIR:Ag level. The crossed-immunoelectrophoresis of plasmas with discrepant VIIIR:Ag and VIIIR:RCof showed variation from the normal pattern.
Subject(s)
Factor VIII/analysis , Multiple Myeloma/blood , Antigens/analysis , Factor VIII/immunology , Humans , Immunoelectrophoresis, Two-Dimensional , Multiple Myeloma/diagnosis , Multiple Myeloma/diagnostic imaging , Radiography , Waldenstrom Macroglobulinemia/blood , von Willebrand Factor/analysisABSTRACT
It was the purpose of this study to examine the effect of 1,4-bis[3-(3,4,5-trimethoxybenzoyl-oxy)propyl]-perhydro-1,4-diazepine (dilazep) on platelet function in vivo, compared with that of dipyridamole. 15 patients were given oral doses of 300 mg dilazep daily, and another 15 patients received oral doses of 450 mg dipyridamole daily. Blood was withdrawn 2 and 4 weeks after the start of treatment, in each case 2 h after administration of the drug. The results were as follows: bleeding time was prolonged in both groups; there was a percentage reduction of circulating platelet aggregates in both groups, but this was statistically significant in the dilazep group only; platelet aggregation was decreased in both groups, several parameters (minimum dose required to induce aggregation, collagen lag phase) were statistically significantly improved in the dilazep group only; platelet malondialdehyde production was unchanged; no changes were demonstrated in platelet shape, fibrinogen concentration, partial thromboplastin time, or prothrombin activity.
Subject(s)
Azepines/pharmacology , Dilazep/pharmacology , Dipyridamole/pharmacology , Adult , Aged , Female , Fibrinogen/metabolism , Humans , Male , Malondialdehyde/blood , Middle Aged , Partial Thromboplastin Time , Platelet Aggregation/drug effects , Platelet Count , Prothrombin Time , Time FactorsABSTRACT
Five patients affected by aseptic dural sinus thrombosis have been treated with a combination of heparin sodium and urokinase. In all of them, the therapy was followed by complete clinical recovery. Postoperative cerebral angiography showed patency of the involved sinuses in all.
Subject(s)
Endopeptidases/administration & dosage , Heparin/administration & dosage , Sinus Thrombosis, Intracranial/drug therapy , Urokinase-Type Plasminogen Activator/administration & dosage , Adolescent , Adult , Brain/diagnostic imaging , Cerebral Angiography , Child , Drug Therapy, Combination , Female , Humans , Infusions, Parenteral , Male , Middle Aged , Sinus Thrombosis, Intracranial/diagnosis , Sinus Thrombosis, Intracranial/diagnostic imaging , Tomography, X-Ray ComputedABSTRACT
Percentage of megathrombocytes, platelet regeneration time (PRT) and platelet-Associated IgG (Pl-A-IgG) were investigated in 12 patients with clinical features consistent with idiopathic thrombocytopenic purpura and in 11 patients with thrombocytopenia associated with chronic liver disease. Bone marrow smears were also examined and megakaryocytes classified into stages I-III according to the current principle. Of 12 patients with idiopathic thrombocytopenic purpura the percentage of megathrombocytes was increased in 9, PRT reduced in 10, and Pl-A-IgG increased in 8 patients. A statistically significant correlation was found between the percentage of megathrombocytes and the level of Pl-A-IgG. A slight correlation was also found between PRT and the percentage of megathrombocytes, while a significant correlation was found between megakaryocytes in stage I and the percentage of megathrombocytes, suggesting that growth of megakaryocytes probably contributes to platelet heterogeneity. In patients with thrombocytopenia and chronic liver disease, the percentage of megathrombocytes was in the normal range. A moderately increased level of Pl-A-IgG was found only in patients with active chronic hepatitis, PRT was reduced only in a few patients, while most of them also showed an increase of Pl-A-IgG.
