ABSTRACT
The Holy Shroud is a relic of great historical importance that, according to catholic tradition, represents the "Sudarium" i.e. the "Sindon" of Jesus Christ. By several techniques, the most recent studies try to establish a well defined dating of the Holy Shroud. In addition an attempt is also made to find out the best mean to preserve the relic. We have to this purpose performed microbiological tests on specimens (Dusts) from the Holy Shroud establishing the microbic content in various spots. Besides few exceptions, the bacteria and fungi found on the Shroud and related objects are common and spread in all the areas examined.
Subject(s)
Bacteria/isolation & purification , Christianity , Dust/analysis , Mortuary Practice/history , History, AncientABSTRACT
The antibacterial activity of NaFosfomicin and of two of its aminoacidic derivatives -Lisin-Fosfomycin and Arginin-Fosfomycin- has been determined "in vitro" as MICs and MBCs, on different groups of Bacteria. The results obtained were then statistically analyzed - according to the "t of Student" - in a comparative evaluation of the values between NaFosfomycin-Lisin-Fosfomycin (F-LF); NaFosfomycin-Arginin-Fosfomycin (F-AF); Lisin-Fosfomycin-Arginin-Fosfomycin (LF-AF). From these comparisons, the data found demonstrated no significant differences among the three compounds, for Proteus, Coliforms and Pseudomonas groups, while Salmonella and Staphylococcus Genera showed good differences (P less than 0.05) from the comparison F-AF.
Subject(s)
Anti-Bacterial Agents/pharmacology , Arginine/pharmacology , Bacteria/drug effects , Fosfomycin/pharmacology , Lysine/pharmacology , Drug Combinations , Microbial Sensitivity TestsABSTRACT
Experiments were conducted to explore the possibility that bacterial strains treated with subminimal inhibitory concentrations (sub-MICs) of fosfomycin might induce immune responses different from those induced by intact, untreated bacteria. A preliminary study was done with a strain of Salmonella wien. The immune response in rabbits immunized with bacteria that had been exposed to either the sub-MIC or the minimal inhibitory concentration (MIC) of fosfomycin was compared with that in rabbits immunized with S. wien not exposed to the drug. The titers of antibody to S. wien in rabbits immunized with abnormal, sub-MIC-treated bacteria were higher than those in rabbits immunized with either MIC-treated or untreated S. wien. This difference was seen not only with the total antigen of Salmonella but also with somatic (O) and flagellar (H) antigens.
Subject(s)
Anti-Bacterial Agents/administration & dosage , Antibodies, Bacterial/analysis , Fosfomycin/administration & dosage , Salmonella/immunology , Agglutination Tests , Animals , Immunoglobulin G/analysis , Immunoglobulin M/analysis , Male , Mercaptoethanol/pharmacology , Rabbits , Salmonella/drug effectsABSTRACT
Among the cephalosporin antibiotics, a relatively new derivative of Cefamandole has been studied, the sodium salt of its formyl ester, Cefamandole nafate. It has shown a broad spectrum of antibiotic activity against a wide variety of Gram-positive and Gram-negative Bacteria (127 strains); the susceptibility was good even with beta-lactamase-producing bacteria. Good protective doses (PD50) were found after mice infections with Staphylococcus aureus and Salmonella wien. The pharmacokinetics of Cefamandole carried out comparatively in 5 human volunteers and in laboratory animals exhibited high levels, especially in the urines.
