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1.
Br J Nutr ; 101(7): 961-6, 2009 Apr.
Article in English | MEDLINE | ID: mdl-19353762

ABSTRACT

A study was conducted in healthy elderly living independently in senior housing to assess the impact of a probiotic yoghurt supplement on small intestinal bacterial overgrowth. Twenty-three participants with positive and thirteen participants with negative hydrogen breath test were studied before and after a period of 4 weeks of probiotic yoghurt administration. Intestinal permeability, plasma endotoxin levels, phagocytic activity of leucocytes, cytokine production by monocytes and free radical response of neutrophils were determined. Intestinal permeability was similar for the two groups and was unaffected by probiotic treatment. Both plasma endotoxin levels and the basal phagocytic activity of leucocytes decreased after yoghurt intake in the two groups. Exposure of monocytes and neutrophils ex vivo led to an increased cytokine response and free radical response, respectively. The normalisation of the various cytokine responses was more apparent in the group with positive breath test. In addition, the plasma levels of lipoplysaccharide binding protein and soluble CD14, lipoplysaccharide pattern recognition receptors and surrogate markers of lipoplysaccharide permeability were diminished by the end of the study. In conclusion, probiotic administration in the elderly normalises the response to endotoxin, and modulates activation markers in blood phagocytes, and therefore may help reduce low-grade chronic inflammation.


Subject(s)
Bacterial Infections/diet therapy , Ileitis/diet therapy , Intestinal Mucosa/microbiology , Intestine, Small , Probiotics/administration & dosage , Yogurt , Administration, Oral , Aged , Aged, 80 and over , Bacterial Infections/diagnosis , Bacterial Translocation , Breath Tests , Case-Control Studies , Cytokines/metabolism , Endotoxemia/diet therapy , Female , Follow-Up Studies , Humans , Ileitis/diagnosis , Ileitis/microbiology , Intestinal Absorption , Leukocytes, Mononuclear/metabolism , Male , Middle Aged , Neutrophils/metabolism , Phagocytosis , Reactive Oxygen Species/analysis , Statistics, Nonparametric
2.
Am J Orthod Dentofacial Orthop ; 134(4): 480-3, 2008 Oct.
Article in English | MEDLINE | ID: mdl-18929264

ABSTRACT

INTRODUCTION: In orthodontics, facial esthetics is assumed to be related to golden proportions apparent in the ideal human face. The aim of the study was to analyze the putative relationship between facial esthetics and golden proportions in white adolescents. METHODS: Seventy-six adult laypeople evaluated sets of photographs of 64 adolescents on a visual analog scale (VAS) from 0 to 100. The facial esthetic value of each subject was calculated as a mean VAS score. Three observers recorded the position of 13 facial landmarks included in 19 putative golden proportions, based on the golden proportions as defined by Ricketts. The proportions and each proportion's deviation from the golden target (1.618) were calculated. This deviation was then related to the VAS scores. RESULTS: Only 4 of the 19 proportions had a significant negative correlation with the VAS scores, indicating that beautiful faces showed less deviation from the golden standard than less beautiful faces. Together, these variables explained only 16% of the variance. CONCLUSIONS: Few golden proportions have a significant relationship with facial esthetics in adolescents. The explained variance of these variables is too small to be of clinical importance.


Subject(s)
Beauty , Face/anatomy & histology , Adolescent , Cephalometry , Child , Humans , Malocclusion/pathology , Maxillofacial Development , Photography, Dental , Prognosis , Reference Standards , White People
3.
Cleft Palate Craniofac J ; 45(3): 284-8, 2008 May.
Article in English | MEDLINE | ID: mdl-18452361

ABSTRACT

OBJECTIVE: To study the effect of infant orthopedics on satisfaction in motherhood. DESIGN: Prospective two-arm randomized controlled trial in parallel with three participating academic cleft palate centers. Treatment allocation was concealed and was performed by means of a computerized balanced allocation method. SETTING: Cleft palate centers of Amsterdam, Nijmegen, and Rotterdam, the Netherlands. PATIENTS: Two groups of infants with complete unilateral cleft lip and palate and no other malformations. INTERVENTIONS: Group IO+ (n = 27) wore passive maxillary plates during the first year of life, group IO- (n = 27) did not. MAIN OUTCOME MEASURE(S): Mean satisfaction scores were obtained from completed questionnaires at 6, 24, and 58 weeks of age. A 4-point scale was used (1 = very satisfactory to 4 = very unsatisfactory). RESULTS: The range of the mean scores for the individual items on the questionnaires for both groups ranged between 1.1 and 2.4. No differences were found between groups. Mothers appear to be satisfied in motherhood, least satisfied with the available time for themselves, and very satisfied with hugging and walking their babies. No differences were found between groups. CONCLUSIONS: Results from the present study show that infant orthopedics, with a passive plate during the first year of life, in children with a unilateral cleft lip and palate has no influence on the mothers' satisfaction in motherhood.


Subject(s)
Cleft Lip/therapy , Cleft Palate/therapy , Mothers/psychology , Orthotic Devices , Parenting/psychology , Humans , Infant , Orthopedic Procedures , Personal Satisfaction , Prospective Studies , Social Support , Surveys and Questionnaires
4.
Eur J Orthod ; 30(2): 141-6, 2008 Apr.
Article in English | MEDLINE | ID: mdl-18263888

ABSTRACT

The aim of the study was to evaluate the influence of the characteristics of panel members, the effects of gender and Angle Class of adolescent patients on their change in facial aesthetics following orthodontic treatment, and to assess the optimal panel size for epidemiological studies on changes in facial aesthetics after orthodontic treatment. A panel of 74 adult laymen (35 males and 39 females) and a panel of 87 orthodontists (37 males and 50 females) evaluated sets of three post-treatment standardized photographs (one frontal, one three-quarter smiling, and one lateral) of 64 adolescent orthodontic patients in relation to the pre-treatment sets of the same patient on a five-point scale. The main effects of professional background, age, gender, and geographic region of the panel members on the aesthetic scores, as well as their first order interactions were evaluated by multilevel models. Professional background, age, gender, and geographical region of panel members have an influence on the evaluation of the change of facial aesthetics following orthodontic treatment. The effect of gender and Angle Class of the patients on the scores was evaluated by two-way analysis of variance. There was no difference in the mean scores for boys and girls. Improvement of facial aesthetics by orthodontic treatment was significant for Class I, Class II division 1, and Class II division 2 patients, but not for Class III patients. Based on the intraclass correlation coefficient, a panel of nine randomly selected orthodontists, a panel of 14 randomly selected laymen, or a mixed panel of 13 individuals is sufficient to obtain reliable results in the aesthetic evaluation of adolescent faces, using photographs and a five-point scale.


Subject(s)
Esthetics, Dental , Malocclusion/therapy , Adolescent , Adult , Age Factors , Aged , Analysis of Variance , Dentists , Female , Humans , Male , Middle Aged , Orthodontics, Corrective , Outcome Assessment, Health Care , Photography, Dental , Residence Characteristics , Sex Factors
5.
Am J Orthod Dentofacial Orthop ; 133(2): 188.e1-8, 2008 Feb.
Article in English | MEDLINE | ID: mdl-18249280

ABSTRACT

INTRODUCTION: Many guidelines, norms, and ideal ratios and angles for attractive faces have been proposed in the literature. The aim of this study was to test the hypothesis that facial attractiveness in adolescents is related to ideal angles and ratios, as indicated in the literature. METHODS: Seventy-six laypeople viewed sets of photographs of 64 adolescents and rated them on a visual analog scale (VAS) from 0 to 100. The facial esthetic value of each subject was calculated as a mean VAS score. Three observers recorded the positions of 61 landmarks, and 45 were found to have acceptable reproducibility. Based on these 45 landmarks, 27 ideal ratios on frontal photographs and 26 ideal angles on lateral photographs were identified in the literature. These ratios and angles were calculated on each photograph, and their deviation from the ideal targets in the literature were determined. Each deviation was related to the VAS score. RESULTS: Two ratios and 3 angles had a significant negative correlation with the VAS scores, indicating that beautiful faces have less deviation from the ideal target than less beautiful faces. Together, these variables explained 28.7% of the variance. CONCLUSIONS: Few "ideal" ratios and angles have a significant relationship with facial esthetics in adolescents.


Subject(s)
Beauty , Esthetics, Dental , Face/anatomy & histology , Adolescent , Cephalometry , Child , Female , Humans , Male , Malocclusion/psychology , Photography, Dental , Reference Standards
6.
Cleft Palate Craniofac J ; 45(1): 81-6, 2008 Jan.
Article in English | MEDLINE | ID: mdl-18215102

ABSTRACT

OBJECTIVE: To test the reliability of some cephalometric measurements in unilateral cleft lip and palate patients. Measurements with A, ANS, and PNS, were compared to measurements performed with alternatives for point A, ANS, and PNS: A1, A2, ANS1, ANS2, and PNS1. PATIENTS: One hundred sixty-four children with complete unilateral cleft lip and palate (UCLP), with a lateral head film taken at age 4 to 6 years. MEAN OUTCOME MEASURES: Intraobserver and interobserver reliability for cephalometric measurements including A, ANS, PNS or their alternatives: Dahlberg errors, systematic errors, and Pearson correlation coefficients were calculated. RESULTS: The measurements using ANS and PNS or their alternatives, were comparable. The systematic error between observers for measurements using A2 was less than for measurements using A or A1. The scatterplot of point A showed a slightly better distribution of the points than the plots of A1 and A2. CONCLUSIONS: Although the landmarks A, ANS, and PNS are hard to trace in UCLP patients with tooth germs in the anterior maxilla, no better landmarks were found in this study. Cephalometric studies using A, ANS, and PNS in UCLP patients should be interpreted with caution.


Subject(s)
Cephalometry/methods , Cleft Lip/diagnostic imaging , Cleft Palate/diagnostic imaging , Facial Bones/diagnostic imaging , Maxillofacial Development , Age Factors , Child , Child, Preschool , Cleft Lip/therapy , Cleft Palate/therapy , Facial Bones/abnormalities , Functional Laterality , Humans , Image Processing, Computer-Assisted/methods , Radiography , Reproducibility of Results , Retrospective Studies , Skull/anatomy & histology , Skull/diagnostic imaging
7.
J Public Health Dent ; 67(3): 179-84, 2007.
Article in English | MEDLINE | ID: mdl-17899905

ABSTRACT

OBJECTIVES: This study was undertaken to test the hypotheses that using the atraumatic restorative treatment (ART) approach results in lower patient anxiety and that lower anxiety leads to higher restoration/extraction ratios. METHODS: The test group of dental operators (n = 9) was trained in ART The control group (n = 11) was not, and did not apply ART The Short Form of the Dental Subscale of the Children's Fear Survey Schedule (CFSS-SF) and Corah's Dental Anxiety Scale (DAS) were used to assess patient anxiety after ART (test group) and after traditional restorations (control group). The restoration/extraction ratio calculated for primary (children) and permanent dentitions (adults) per operator was based on 12-month treatment statistics. Dental anxiety assessments were analysed using ANOVA. Differences were compared using the t-test and corrected for confounding factors (ANCOVA). The Pearson correlation coefficient was used to measure the correlation between dental anxiety levels and restoration/extraction ratios. RESULTS: The mean CFSS-SF score for test-group children was statistically significantly lower than for the control-group children. The mean DAS score for test-group adults was statistically significant lower than the control. No significant correlation was observed between dental anxiety level and restoration/extraction ratio per operator for both dentitions in both groups. CONCLUSION: The first hypothesis was accepted; the second, rejected. Although dental anxiety scores were lower both in child and in adult patients treated by ART than in those who received traditional restorative treatments, this positive effect had not resulted in higher restoration/extraction ratios.


Subject(s)
Dental Anxiety/prevention & control , Dental Cavity Preparation/methods , Dental Restoration, Permanent/methods , Tooth Extraction/methods , Adolescent , Adult , Ambulatory Care , Analysis of Variance , Child , Dental Clinics , Dental Restoration, Permanent/statistics & numerical data , Humans , Manifest Anxiety Scale , Minimally Invasive Surgical Procedures , Public Health Dentistry , South Africa , Tooth Extraction/statistics & numerical data
8.
Am J Orthod Dentofacial Orthop ; 132(2): 165-70, 2007 Aug.
Article in English | MEDLINE | ID: mdl-17693365

ABSTRACT

INTRODUCTION: Although it is well known that treatment with fixed appliances increases the risk of enamel demineralization, little information is available about preventive measures that orthodontists actually use. This study was executed to survey measures used in orthodontic practices to prevent decalcifications during fixed appliance treatment, and to compare these measures with the available evidence-based information. METHODS: A questionnaire was sent to all privately practicing orthodontists in the Netherlands who were affiliated with the Dutch Dental Association. RESULTS: Of 229 orthodontists, 178 (78%) returned the questionnaires. Most of the orthodontists had a basic practice protocol for preventing demineralizations at the start of treatment. This protocol nearly always included oral hygiene instructions. If demineralizations occurred, 99% of the orthodontists took extra measures. Comparing the measures applied in the orthodontic practices with the evidence from a systematic review, a number of differences became apparent. The additional use of chlorhexidine or toothpaste with a high fluoride concentration (which has been demonstrated to have an inhibitive effect) is rarely prescribed. Fluoride rinse is prescribed most often, although there is not any high-quality, long-term study that demonstrates a caries preventive effect in orthodontic patients. Sixty-eight percent of the orthodontists considered it necessary to develop a practice guideline for preventing demineralizations. CONCLUSIONS: Orthodontists do not implement the available evidence in order to prevent enamel demineralizations during fixed-appliance treatment. A practice guideline incorporating this information should be developed.


Subject(s)
Cariostatic Agents/therapeutic use , Fluorides/therapeutic use , Orthodontics, Corrective/methods , Practice Guidelines as Topic , Practice Patterns, Dentists'/standards , Tooth Demineralization/prevention & control , Dentin-Bonding Agents/chemistry , Dentin-Bonding Agents/therapeutic use , Evidence-Based Medicine/methods , Humans , Netherlands , Oral Hygiene/education , Oral Hygiene/methods , Orthodontic Appliances/adverse effects , Surveys and Questionnaires , Tooth Demineralization/drug therapy
9.
Oral Health Prev Dent ; 5(1): 55-61, 2007.
Article in English | MEDLINE | ID: mdl-17366762

ABSTRACT

PURPOSE: To estimate the survival of retention of sealant extension to occlusal ART restorations over 6.3 years; and to test the null-hypothesis that there is no difference in dentine caries lesion development in sealant extension to ART restorations in comparison with sealant free extensions to amalgam restorations in occlusal surfaces over 6.3 years. MATERIALS AND METHODS: In a parallel group design, 318 and 254 grade 2 children were randomly assigned to the ART and amalgam group respectively. Eight dentists placed 925 evaluatable single- and multiple-surfaces restorations. A total of 424 sealed extensions to occlusal ART and 284 sealant free extensions to occlusal amalgam restorations were available for analyses. The modified actuarial method was used to estimate survival percentages. The jackknife method was applied to calculate the SE in the cumulative survival percentages. RESULTS: After 6.3 years, 11.2% (SE = 2.2%) of sealant extensions were fully retained and 16.7% (SE = 2.8%) were partially retained. After 6.3 years, 86.4% (SE = 2.2%) of the sealed pits and fissures adjacent to occlusal ART restorations and 89.9% (SE = 2.4%) of non-sealed pits and fissures adjacent to occlusal amalgam restorations were free of dentine caries lesions. Neither this difference nor those at earlier evaluation years were statistically significant (p > 0.05). CONCLUSION: Sealing pits and fissures adjacent to occlusal ART restorations did not result in a caries preventive benefit over non-sealed pits and fissures adjacent to occlusal amalgam restorations in this group of children over 6.3 years.


Subject(s)
Dental Amalgam , Dental Caries/prevention & control , Dental Restoration, Permanent/methods , Pit and Fissure Sealants/therapeutic use , Child , DMF Index , Dental Amalgam/chemistry , Dental Bonding , Dental Caries/therapy , Dentin/pathology , Female , Follow-Up Studies , Glass Ionomer Cements/chemistry , Humans , Longitudinal Studies , Male , Surface Properties , Survival Analysis
10.
Eur J Oral Sci ; 114(6): 449-55, 2006 Dec.
Article in English | MEDLINE | ID: mdl-17184224

ABSTRACT

This systematic review aimed to determine the caries-inhibiting effect of chlorhexidine (CHX) varnishes on the permanent dentition of children, adolescents and young adults, and to explore two possibly related factors, namely application frequency and the time between evaluation and the last application. The literature search identified 14 publications of randomized controlled trials or controlled clinical trials where the effect of CHX varnish was compared with placebo controls or controls that received no preventive treatment. To obtain uniform outcome effects, the prevented fraction and 95% confidence intervals of caries increment were calculated. Owing to insufficient data presentation, only eight publications were included. Another two publications were included after receiving additional data from the authors. This systematic review did not result in a meta-analysis as an overall prevented fraction could not be computed because of the large variation of outcome results. The variation could not be explained by the time between evaluation and last application but might be explained by application frequency. It is tentatively concluded that CHX varnish has a moderate caries-inhibiting effect when applied every 3-4 months. However, this effect seems to have diminished by around 2 yr after the last application. There is no evidence for a caries-inhibiting effect of CHX varnish with longer intervals between applications.


Subject(s)
Anti-Infective Agents, Local/administration & dosage , Cariostatic Agents/administration & dosage , Chlorhexidine/administration & dosage , Dental Caries/prevention & control , Adolescent , Adult , Child , Controlled Clinical Trials as Topic , Humans , Paint , Research Design , Time Factors
11.
Cleft Palate Craniofac J ; 43(6): 665-72, 2006 Nov.
Article in English | MEDLINE | ID: mdl-17105327

ABSTRACT

OBJECTIVE: Evaluation of the effect of infant orthopedics on maxillary arch dimensions in the deciduous dentition in patients with unilateral cleft lip and palate. DESIGN: Prospective two-arm randomized controlled clinical trial with three participating cleft palate centers. SETTING: Cleft palate centers of the Radboud University Nijmegen Medical Center, Academic Center of Dentistry Amsterdam, and University Medical Center Rotterdam, the Netherlands. PATIENTS: Children with complete unilateral cleft lip and palate (n = 54) were included. INTERVENTIONS: Patients were randomly divided into two groups. Half of the patients (IO+) had a presurgical orthopedic plate until surgical closure of the soft palate at the age of 52 weeks; the other half (IO-) did not undergo presurgical orthopedics. MEAN OUTCOME MEASURES: Maxillary arch dimensions were assessed on dental casts at 4 and 6 years of age with measurements for arch width, arch depth, arch length, arch form, and the vertical position of the lesser segment. Contact and collapse were assessed also. RESULTS: There were no clinically significant differences found between IO+ and IO- for any of the variables. CONCLUSIONS: Infant orthopedics had no observable effect on the maxillary arch dimensions or on the contact and collapse scores in the deciduous dentition at the ages of 4 and 6 years. Considering the Dutchcleft results to date, there is no need to perform infant orthopedics for unilateral cleft lip and palate patients.


Subject(s)
Cleft Lip/therapy , Cleft Palate/therapy , Dental Arch/pathology , Maxilla/pathology , Orthodontic Appliances , Tooth, Deciduous , Alveolar Process/pathology , Cephalometry , Child , Child, Preschool , Cleft Lip/surgery , Cleft Palate/surgery , Female , Follow-Up Studies , Humans , Infant , Lip/surgery , Male , Palate, Hard/surgery , Palate, Soft/surgery , Prospective Studies , Reproducibility of Results
12.
Cleft Palate Craniofac J ; 43(6): 659-64, 2006 Nov.
Article in English | MEDLINE | ID: mdl-17105328

ABSTRACT

OBJECTIVE: To study the effect of infant orthopedics on facial appearance. DESIGN: Prospective two-arm randomized controlled trial in parallel with three participating academic cleft palate centers. Treatment allocation was concealed and performed by means of a computerized balanced allocation method. SETTING: Cleft Palate Centers of Amsterdam, Nijmegen, and Rotterdam, the Netherlands. PATIENTS: Infants with complete unilateral cleft lip and palate, no other malformations. INTERVENTIONS: One group (IO(+)) wore passive maxillary plates during the first year, the other group (IO(-)) did not. MAIN OUTCOME MEASURE(S): Two metrical response modalities were used (i.e., visual analog scales and reference scores) to score facial appearance. Full face and cropped photographs were compared with reference photographs and were judged. The photographs were judged by 45 judges, 24 laypeople, and 21 professionals. Transformation of the scores into z scores was applied to compare and to pool both response modalities. The validity of each individual judge was evaluated, as was the reliability of the scales. Differences between the treatment groups were evaluated by means of t tests. RESULTS: Photographs were available of 41 subjects, 21 with and 20 without infant orthopedics. No significant differences were found between groups. Mean z-score values for the full-face photographs were: group IO(+) = 0.10 (SD = 0.73) and group IO(-) = -0.03 (SD = 0.48); for the cropped photographs were: group IO(+) = 0.12 (SD = 0.71) and group IO(-) = -0.06 (SD = 0.55). CONCLUSIONS: Infant orthopedics have no effect on facial appearance.


Subject(s)
Cleft Lip/therapy , Cleft Palate/therapy , Esthetics , Face , Orthodontic Appliances , Attitude to Health , Cleft Lip/pathology , Cleft Lip/surgery , Cleft Palate/pathology , Cleft Palate/surgery , Female , Follow-Up Studies , Humans , Infant , Infant, Newborn , Male , Photography , Prospective Studies , Reproducibility of Results , Treatment Outcome
13.
Angle Orthod ; 76(5): 768-72, 2006 Sep.
Article in English | MEDLINE | ID: mdl-17029508

ABSTRACT

OBJECTIVE: The purpose of this investigation was to study the relationship between vertical skeletal growth pattern and dental maturation in children with long or short anterior facial height. MATERIALS AND METHODS: The sample consisted of the records of 312 Dutch children (153 boys and 159 girls, aged 9-12.9 years, with a mean chronological age of 11.3 years). The subjects were selected according to their lower anterior facial height as a percentage of the total facial height. Two groups, one with long and the other with short anterior facial height, were formed for further comparison. Dental age, according to Demirjian's dental maturity score, was determined for each subject. The power of the study was 79% (2-sided test) and 87% (1-sided test). RESULTS: There was no statistically significant difference in dental age score between the two extreme groups. The subjects with short anterior facial height demonstrated a slight tendency toward more advanced dental age. CONCLUSIONS: The difference in dental age between long and short facial types is not big enough to be clinically relevant.


Subject(s)
Facial Bones/growth & development , Odontogenesis/physiology , Vertical Dimension , Age Determination by Skeleton , Age Determination by Teeth , Cephalometry/methods , Child , Chin/pathology , Female , Humans , Incisor/pathology , Male , Malocclusion/pathology , Mandible/pathology , Maxilla/pathology , Nasal Bone/pathology
14.
Cleft Palate Craniofac J ; 43(5): 612-5, 2006 Sep.
Article in English | MEDLINE | ID: mdl-16986989

ABSTRACT

OBJECTIVE: To assess dental age in children with a complete unilateral cleft lip and palate and to compare this with a noncleft control group. DESIGN: Two-group, mixed-longitudinal cohort study. SETTING: Cleft group from an academic center for cleft lip and palate treatment. Noncleft control group from the same population. PATIENTS: Participants included 70 Caucasian children with a full complement of teeth and a complete unilateral cleft lip and palate (45 boys and 25 girls) from the Cleft Palate Craniofacial Center at the Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands. The control group (90 boys and 91 girls) was taken from the Nijmegen Growth Study. MAIN OUTCOME MEASURE: Dental age was assessed on orthopantomograms. In the unilateral cleft lip and palate group, linear interpolation in individual age curves was applied to obtain the dental age at 5, 9.5, and 14 years of age. For these ages, a comparison was made with the noncleft control group. RESULTS: Boys and girls with a unilateral cleft lip and palate showed a significant delay in dental age, as compared with their noncleft peers at all three ages. This delay was more pronounced in boys than in girls. The gender effect was significant at chronological ages 5 and 14 years. CONCLUSIONS: Children with a complete unilateral cleft lip and palate have a delay in dental age, compared with noncleft children.


Subject(s)
Age Determination by Teeth/methods , Cleft Lip , Cleft Palate , Mandible/diagnostic imaging , Maxillofacial Development , Adolescent , Case-Control Studies , Child , Child, Preschool , Cleft Lip/diagnostic imaging , Cleft Palate/diagnostic imaging , Cohort Studies , Female , Humans , Longitudinal Studies , Male , Sex Factors
15.
Int Dent J ; 56(6): 345-51, 2006 Dec.
Article in English | MEDLINE | ID: mdl-17243467

ABSTRACT

The number of publications reporting on the survival of ART sealants and ART restorations has increased considerably in recent years. A systematic investigation of their longevity is therefore warranted. Based on three exclusion criteria, a literature search in the electronic libraries Pubmed and Medline revealed 28 eligible publications for inclusion in a meta-analysis. High mean survival rates for single-surface ART restorations using high-viscosity glass-ionomer in primary dentitions over 3 years were found (95% after 1 year to 86% after 3 years). These rates were statistically significantly higher than for those of multiple-surface ART restorations in primary dentitions (p<0.0001). High mean survival rates for single-surface ART restorations using high-viscosity glass-ionomer in permanent dentitions over 6 years were found (97% after 1 year to 72% after 6 years). The mean annual failure rates for single-surface ART restorations using high-viscosity glass-ionomer in primary and permanent dentitions and for multiple-surface ART restorations in primary dentitions are 4.7%, 4.7% and 17%, respectively. The number of studies reporting on the retention and caries preventive effect of ART sealants was low. It is concluded that single-surface ART restorations using high-viscosity glass-ionomer in both primary and permanent dentitions show high survival rates. Medium-viscosity glass-ionomer should not be used for ART restorations.


Subject(s)
Acrylic Resins/chemistry , Dental Caries/therapy , Dental Materials/chemistry , Dental Restoration Failure , Dental Restoration, Permanent/methods , Silicon Dioxide/chemistry , Confidence Intervals , Dental Caries/prevention & control , Dentition, Permanent , Humans , Survival Analysis , Tooth, Deciduous
16.
Plast Reconstr Surg ; 116(5): 1255-62, 2005 Oct.
Article in English | MEDLINE | ID: mdl-16217465

ABSTRACT

BACKGROUND: The goal of this study was to assess determinants for treatment outcome in unilateral cleft lip and palate, evaluated according to the Great Ormond Street London and Oslo (GOSLON) Yardstick and 5-year-index ratings by means of a meta-analysis. METHODS: Multiple databases were searched for publications in which patient groups were evaluated by GOSLON ranking or the GOSLON-like 5-year index. From the 15 selected publications, the following background variables could be extracted and were evaluated as determinants for treatment outcome in unilateral cleft lip and palate: year of birth, average age of the patient at the time of GOSLON classification, racial background, presence of Simonart's band, infant orthopedics, palatal closure before the age of 3 versus palatal closure at a later age, bone graft, and number of surgeons. RESULTS: The total number of patients included in the meta-analysis was 1236. Patients whose soft and hard palate were closed before the age of 3 presented significantly poorer (p = 0.003) GOSLON scores (mean score, 2.9; SD 0.4) than patients whose palate was closed at a later age (mean GOSLON score, 2.3; SD 0.2). CONCLUSIONS: Delayed palatal closure generally results in better dental arch relationships than early palatal closure. Well-designed, randomized clinical trials are required for further investigation of the optimal timing for palatal closure.


Subject(s)
Cleft Lip/surgery , Cleft Palate/surgery , Age Factors , Child, Preschool , Dental Arch/physiopathology , Humans , Malocclusion/classification , Palate, Hard/surgery , Treatment Outcome
17.
Cleft Palate Craniofac J ; 42(5): 512-6, 2005 Sep.
Article in English | MEDLINE | ID: mdl-16149832

ABSTRACT

OBJECTIVE: To evaluate dental arch relationships of patients with unilateral cleft lip and palate (UCLP) treated with a two-stage palatal closure and to compare them with the six centers from the Eurocleft study that used various treatment protocols. DESIGN: Repeated-measures study. SETTING: Cleft Palate Craniofacial Unit of Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands. PATIENTS: Records of 9-year-old children with complete unilateral cleft lip and palate (n = 43) were included. INTERVENTIONS: The dental arch relationships of these patients were assessed by applying the Goslon Yardstick and subsequently compared with the Goslon outcome of the six-center Eurocleft study. MEAN OUTCOME MEASURES: Statistics of intra- and interexaminer agreement. RESULTS: For the Nijmegen UCLP group, 9% of dental arch relationships had a Goslon score of 1, 52% had a score of 2, 30% has a score of 3, 9% had a score of 4, and none had a score of 5. The mean Nijmegen Goslon score showed no significant differences with Eurocleft centers A, B, and E, which achieved the best treatment results, but did significantly differ from Goslon outcomes of Eurocleft centers D (p < .001), C, and F (p < .01), which had relatively poor treatment outcome. CONCLUSIONS: Treatment outcome of the patients in the Nijmegen UCLP group treated with two-stage palatal closure was comparable with the results of the Eurocleft centers with the best outcome. Treatment protocol could not explain differences in the quality of treatment results.


Subject(s)
Cleft Lip/surgery , Cleft Palate/surgery , Palate/surgery , Age Factors , Bone Transplantation , Child , Clinical Protocols , Dental Arch/pathology , Humans , Multicenter Studies as Topic , Observer Variation , Palate/pathology , Palate, Hard/pathology , Palate, Hard/surgery , Reproducibility of Results , Treatment Outcome
18.
Cleft Palate Craniofac J ; 42(2): 171-7, 2005 Mar.
Article in English | MEDLINE | ID: mdl-15748108

ABSTRACT

OBJECTIVE: To study the effects of infant orthopedics (IO) on feeding, weight, and length. DESIGN: Prospective two-arm randomized controlled trial in three academic Cleft Palate Centers. Treatment allocation was concealed and performed by means of a computerized balanced allocation method. SETTING: Cleft Palate Centers of Amsterdam, Nijmegen, and Rotterdam, the Netherlands. PATIENTS: Infants with complete unilateral cleft lip and palate (UCLP), no other malformations. INTERVENTIONS: One group (IO+) wore passive maxillary plates during the first year of life, but the other group (IO-) did not. All other interventions were the same for both groups. MAIN OUTCOME MEASURES: Bottle feeding velocity (mL/min) at intake, 3, 6, 15, and 24 weeks (T0 to T24); weight-for-age, length-for-age, and weight-for-length using z scores; reference values from the Netherlands' third nationwide survey on growth. RESULTS: Feeding velocity increased with time from 2.9 to 13.2 mL/min in the IO- group and from 2.6 to 13.8 mL/min in the IO+ group; no significant differences were found between groups. Weight-for-age, length-for-age, and weight-for-length (z scores) did not differ significantly between groups, but overall the infants with unilateral cleft lip and palate in both groups had significantly lower mean z scores for weight-for-age and height-for-age than the reference during the first 14 months, and had lower mean values for weight-for-length after soft palate closure. CONCLUSION: Infant orthopedics with the aim of improving feeding and consequent nutritional status in infants with unilateral cleft lip and palate can be abandoned.


Subject(s)
Cleft Palate/therapy , Infant Nutrition Disorders/prevention & control , Orthodontics, Preventive , Palatal Obturators , Body Height , Body Weight , Bottle Feeding , Breast Feeding , Cleft Lip/therapy , Humans , Infant , Nutritional Status , Regression Analysis
19.
Cleft Palate Craniofac J ; 41(6): 633-41, 2004 Nov.
Article in English | MEDLINE | ID: mdl-15516167

ABSTRACT

OBJECTIVE: Evaluation of the effect of infant orthopedics (IO) on the occlusion of the deciduous dentition in patients with unilateral cleft lip and palate (UCLP). DESIGN: Prospective, two-arm, randomized, controlled clinical trial with three participating cleft palate centers (Dutchcleft). SETTING: Cleft Palate Centers of the University Medical Center Nijmegen, Academic Center of Dentistry Amsterdam, and Dijkzigt University Hospital Rotterdam, The Netherlands. PATIENTS: Children with complete UCLP (n = 54) were included. INTERVENTIONS: In a concealed allocation procedure, half of the patients was randomized to wear a plate till surgical closure of the soft palate (IO+), and the other half (IO-) did not have a plate. MEAN OUTCOME MEASURES: Dental arch relationships were assessed at 4 and 6 years of age with the 5-year-old index; the Huddart-score; and measurements of overjet, overbite, and sagittal occlusion. RESULTS: There were no significant differences found between the IO+ and IO- groups for the 5-year-old index; the Huddart-score; and overjet, overbite, and sagittal occlusion. CONCLUSIONS: IO had no observable effect on the occlusion in the deciduous dentition at 4 and 6 years of age. Considering the occlusion only, there is no need to perform IO in children with UCLP.


Subject(s)
Cleft Lip/complications , Cleft Palate/complications , Dental Occlusion , Malocclusion/prevention & control , Orthodontics, Preventive/instrumentation , Child , Child, Preschool , Female , Humans , Male , Malocclusion/etiology , Observer Variation , Preoperative Care , Prospective Studies , Reproducibility of Results , Tooth, Deciduous , Treatment Outcome
20.
Cleft Palate Craniofac J ; 41(6): 646-50, 2004 Nov.
Article in English | MEDLINE | ID: mdl-15516169

ABSTRACT

OBJECTIVE: To investigate the reliability of using photographs of study casts as an alternative to casts for rating dental arch relationships. DESIGN: Repeated-measures study. SETTING: Cleft Palate Center of the University Medical Center Nijmegen, Nijmegen, The Netherlands. PATIENTS: Records of children with complete unilateral cleft lip and palate (UCLP) (n = 49) at the age of 9 years were included. MEAN OUTCOME MEASURE(S): Statistics of intra- and interexaminer agreement. RESULTS: No significant differences were found between the rating of dental casts and photographs of dental casts, using the Goslon Yardstick. CONCLUSIONS: Photographs of dental casts provide a consistent, reproducible method for rating dental arch relationships in patients with UCLP at the age of 9 years and provide a reliable alternative to the application of the Goslon Yardstick on dental casts.


Subject(s)
Cleft Lip/complications , Cleft Palate/complications , Jaw Relation Record/methods , Malocclusion/diagnosis , Models, Dental , Photography, Dental , Child , Dental Arch/pathology , Dental Occlusion , Humans , Malocclusion/etiology , Observer Variation , Reproducibility of Results
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