Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 7 de 7
Filter
Add more filters










Database
Language
Publication year range
1.
Am J Obstet Gynecol ; 165(5 Pt 1): 1552-7, 1991 Nov.
Article in English | MEDLINE | ID: mdl-1659787

ABSTRACT

The therapeutic effect of a single, oral dose of itraconazole was studied in rats inoculated intravaginally with Candida albicans and in which an established vaginal infection was present. We used light microscopy, transmission and scanning electron microscopy to document the structural alterations in the 3 days after treatment. The most important observations include the speed (within 24 hours) with which itraconazole inhibits the further penetration of the fungus into the vaginal squamous epithelium, the ability of the drug to reach and structurally alter intracellularly located fungal elements, and the prolonged drug effect of a single dose leading to complete eradication of the fungus from the vagina within 3 days.


Subject(s)
Antifungal Agents/therapeutic use , Candida albicans/drug effects , Candidiasis, Vulvovaginal/drug therapy , Ketoconazole/analogs & derivatives , Administration, Oral , Animals , Candida albicans/ultrastructure , Candidiasis, Vulvovaginal/pathology , Female , Itraconazole , Ketoconazole/therapeutic use , Microscopy, Electron , Rats , Rats, Inbred Strains
2.
Antimicrob Agents Chemother ; 17(6): 922-8, 1980 Jun.
Article in English | MEDLINE | ID: mdl-6250469

ABSTRACT

Ketoconazole, an orally active antimycotic drug, is a potent inhibitor of ergosterol biosynthesis in Candida albicans when added to culture media which support yeast or mycelial growth or to cultures containing outgrown mycelium. This inhibition coincides with accumulation of sterols with a methyl group at C-14 and can thus be attributed to an interference with one of the reactions involved in the removal of the 14 alpha-methyl group of lanosterol. When administered to rats infected with C. albicans, ketocanazole also inhibits fungal synthesis of ergosterol. A six-times-higher dose is required to effect cholesterol synthesis by rat liver.


Subject(s)
Antifungal Agents/pharmacology , Candida albicans/metabolism , Ergosterol/biosynthesis , Imidazoles/pharmacology , Piperazines/pharmacology , Animals , Candida albicans/drug effects , Candida albicans/growth & development , Cell Membrane/drug effects , Cholesterol/metabolism , Cholesterol/physiology , Culture Media , Dose-Response Relationship, Drug , Female , Ketoconazole , Lanosterol/metabolism , Lanosterol/physiology , Rats , Sterols/biosynthesis , Sterols/isolation & purification , Time Factors
3.
J Med Chem ; 19(9): 1148-55, 1976 Sep.
Article in English | MEDLINE | ID: mdl-978678

ABSTRACT

The synthesis of 1-(2-alkyl-2-phenylethyl)-1H-imidazoles was accomplished starting from the corresponding phenylacetonitriles. Via alkylation, esterification, and sodium borohydride reduction-in the presence of lithium iodide-beta-phenylalconols were obtained. Mesylation of these alcohols and refluxing with imidazole in dimethylformamide furnished title compounds, which were active in vitro against dermatophytes, yeasts, other fungi, and gram-positive bacteria and in vivo as well as in vitro against Candida albicans.


Subject(s)
Antifungal Agents/chemical synthesis , Imidazoles/chemical synthesis , Animals , Antifungal Agents/therapeutic use , Bacteria/drug effects , Candidiasis/drug therapy , Fungi/drug effects , Guinea Pigs , Imidazoles/pharmacology , Imidazoles/therapeutic use , Microbial Sensitivity Tests , Structure-Activity Relationship
4.
Sabouraudia ; 13 Pt 1: 63-73, 1975 Mar.
Article in English | MEDLINE | ID: mdl-1091999

ABSTRACT

The growth of Candida albicans was studied in control cultures and in the presence of miconazole or clotrimazole. Each drug prolonged the lag phase and reduced the total final population. Although miconazole, at the low concentrations used, was a less potent inhibitor than clotrimazole in the main logarithmic phase, it was more fungicidal. The antifungal activity of miconazole on C. albicans was inversely proportional to the number of cells inoculated in the media. The effects of miconazole on growth depended on the nutrients in the medium and were most pronouncedwhen it was added to cultures of C. albicans in the lag and main logarithmic phase of growth. The growth inhibitory effects of sub-fungicidal doses of micronazole (smaller than or equal to 10-6 M) on C. albicans seemed to be reversible.


Subject(s)
Antifungal Agents/pharmacology , Candida albicans/growth & development , Clotrimazole/pharmacology , Imidazoles/pharmacology , Miconazole/pharmacology , Benzene Derivatives , Candida albicans/drug effects , Cell Count , Cell Division/drug effects , Cell Survival , Culture Media , Time Factors
SELECTION OF CITATIONS
SEARCH DETAIL
...