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Platelets ; 22(1): 77-8, 2011.
Article in English | MEDLINE | ID: mdl-20873964

ABSTRACT

We report a case with a hypersensitivity reaction to clopidogrel that resolved after clopidogrel discontinuation and recurred on rechallenge. The reaction included fever, tachycardia, rash and mild angioedema. As an alternative to clopidogrel, the more potent thienopyridine prasugrel was administered without any signs of an allergic reaction in the hours, days and weeks following administration.


Subject(s)
Drug Hypersensitivity/prevention & control , Piperazines/therapeutic use , Purinergic P2Y Receptor Antagonists/adverse effects , Thiophenes/therapeutic use , Ticlopidine/analogs & derivatives , Aged , Angioedema , Clopidogrel , Drug Hypersensitivity/physiopathology , Exanthema , Fever , Humans , Male , Piperazines/administration & dosage , Prasugrel Hydrochloride , Purinergic P2Y Receptor Antagonists/administration & dosage , Tachycardia , Thiophenes/administration & dosage , Thrombosis/prevention & control , Ticlopidine/administration & dosage , Ticlopidine/adverse effects
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