ABSTRACT
Vesico-ureteral reflux (VUR) is a frequent condition, but in most instances, the precise cause is unknown. We here review the evidence of a genetic aetiology of VUR, inherited as an autosomal dominant trait, with variable expression. We discuss the possible pathogenetic relationship between VUR and other types of uropathies and possible strategies towards the identification of genes underlying VUR are presented. The isolation of the gene(s) responsible for uropathies will not only lead to a better insight into the embryology of the urological system, the pathogenesis of uropathies, but also to a renewed interest from clinicians in congenital uropathies.
Subject(s)
Chromosome Aberrations/genetics , Genes, Dominant/genetics , Vesico-Ureteral Reflux/genetics , Child , Chromosome Disorders , Female , Humans , Kidney/abnormalities , Male , Pedigree , Ureter/abnormalities , Ureteral Obstruction/geneticsABSTRACT
The wearable version of the Novacor left ventricular assist system has been implanted in a 44-year-old man as a bridge to retransplantation. Apart from a temporary right ventricular failure, the postoperative course was smooth and the patient underwent retransplantation after 95 days of support. Expected complications like infection or bleeding could be avoided or minimized.