ABSTRACT
Ninety-one hay fever patients received either 0.5 mg/kg oxatomide b.i.d. or 0.4 mg/kg diphenhydramine b.i.d. in a two-month double-blind study. If necessary this dose could be doubled. The results showed that fewer oxatomide patients needed to double this starting dose and to use a nasal spray. Oxatomide proved to be more effective than diphenhydramine in limiting the severity of the hay fever attacks, as evidenced by the findings that oxatomide patients had fewer complaint-days, and that more of these patients were rated by the investigators to have excellent or good results. Apart from daytime fatigue, transient in several patients, no oxatomide-induced side-effects were found.
Subject(s)
Diphenhydramine/therapeutic use , Piperazines/therapeutic use , Rhinitis, Allergic, Seasonal/drug therapy , Adolescent , Adult , Child , Clinical Trials as Topic , Diphenhydramine/adverse effects , Double-Blind Method , Fatigue/chemically induced , Female , Humans , Male , Piperazines/adverse effectsABSTRACT
The authors describe an easy and fast way of nose provocation (aerosol provocation combined with passive anterior rhinomanometry). A comparative study between skin tests, lungprovocations and noseprovocations proves the usefulness of the method.
Subject(s)
Respiratory Function Tests/methods , Adolescent , Aerosols , Allergens , Child , Child, Preschool , Humans , Lung/physiopathology , Nose/physiopathology , Respiratory Hypersensitivity/diagnosis , Skin Tests , Vital CapacityABSTRACT
The authors make a comparative study in 55 CNLSD children and 10 healthy children. In all those children, provocation tests were performed as wel at the level of the skin, as at the level of the lung and nose. The provocation tests were performed with the following allergens: house dust, mites, human dander and pollen, and with histamine. Only in the control group (10 healthy children) no lung provocations with histamine were done. From the investigation follows that skin tests are not always reliable. Furthermore, in many cases a nose provocation test (combination of aerosole. Furthermore, in many cases a nose provocation test (combination of aerosol provocation with a allergen and PAR rhinomanometry) can replace a lung provocation test.
Subject(s)
Allergens , Respiratory Hypersensitivity/immunology , Skin Tests , Child , Chronic Disease , Dust , Histamine , Humans , Lung/immunology , Mites/immunology , Nose/immunology , PollenABSTRACT
The surgical closure of a naso-septal perforation is accompanied by many problems which can interfere with the good result. The authors describe a technique by which a naso-septal perforation can be closed by placing an obturator without performing any surgery.
Subject(s)
Nasal Septum , Nose Deformities, Acquired , Prostheses and Implants , Humans , Nasal Septum/surgery , Nose Deformities, Acquired/surgery , RhinoplastyABSTRACT
The authors describe a simple technique of anterior rhinomanometry. This technique in combination with a allergen aerosol provocation represents a functional test of the nose. The advantage of the method is the fact that in allergic people the provocation reacts directly on the shock tissues, representing a sure and repeatable method of diagnosis.
