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Eur J Clin Pharmacol ; 51(5): 355-8, 1997.
Article in English | MEDLINE | ID: mdl-9049574

ABSTRACT

OBJECTIVE: A randomised, controlled clinical trial was performed to study the long-term effect of gradual withdrawal from benzodiazepines on the daily functioning of residents of homes for the elderly. The planned sample size was not achieved due to recruitment and follow-up problems. RESULTS: The results in this small sample nevertheless suggest that gradual withdrawal from benzodiazepines is possible in residents of homes for the elderly, and that it can have a positive effect on their daily functioning. No major withdrawal symptoms were observed, although there was a decrease in sleep quality during withdrawal. CONCLUSION: The findings are promising for further research, but researchers should anticipate the problems inherent in executing a trial with institutionalised elderly subjects.


Subject(s)
Benzodiazepines/administration & dosage , Substance Withdrawal Syndrome , Aged , Aged, 80 and over , Cognition/drug effects , Double-Blind Method , Drug Utilization , Feasibility Studies , Female , Homes for the Aged , Humans , Male , Practice Patterns, Physicians' , Sleep Initiation and Maintenance Disorders/drug therapy , Time Factors
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