Liver versus cardiothoracic transplant candidates and their pretransplant psychosocial and behavioral risk profiles: good neighbors or complete strangers?

Research concerning pretransplant psychosocial and behavioral characteristics in different organ transplant groups is limited. The aim was to assess relevant psychosocial and behavioral pretransplant factors in heart, lung and liver transplant candidates, and their differences among groups. One hundred and eighty-six transplant candidates (i.e. 71 lung, 33 heart and 82 liver) were included (93% response rate). Demographics, clinical variables, co-morbidity, anxiety, depression, personality traits, received social support and adherence with the therapeutic regimen were assessed using validated self-report instruments and chart review. Because of significant differences in gender, age and co-morbidity among groups, analyses were controlled for these factors. Lung (8.2 +/- 4.2) and heart (7.6 +/- 3.5) transplant candidates tended to report more depressive symptoms than liver transplant candidates (6.5 +/- 4.8) (P = 0.05). Groups were comparable for other factors, except for liver transplant candidates being more frequently active smokers (22%) compared with heart (3%) and lung candidates (0%), and more heart (36.4%) and lung candidates (33.3%) drinking alcohol than liver transplant candidates (6.3%). Psychosocial and behavioral characteristics are comparable among pretransplant candidates. Instead of performing the pretransplant psychosocial and behavioral screening in an organ-specific fashion, our data support the use of a more general screening protocol.

Clinicopathological features of focal nodular hyperplasia-like nodules in 130 cirrhotic explant livers.

OBJECTIVES: Focal nodular hyperplasia-like nodules (FNH-like nodules) are focal lesions occurring in liver cirrhosis and are morphologically very similar to classical FNH in an otherwise normal liver. They are sometimes misdiagnosed as hepatocellular carcinoma (HCC) on imaging because both types of lesions show arterial-phase enhancement. Although the morphological, immunohistochemical, and imaging features of FNH-like nodules are well-known, their pathogenesis and role in hepatocarcinogenesis have not been studied in detail. Therefore, we performed a detailed pathological evaluation of 130 cirrhotic explant livers and correlated these data with the clinical features of the patients. METHODS: All cirrhotic explant livers were uniformly sliced at 5-mm intervals and all detected focal lesions were microscopically classified according to internationally accepted criteria. The obtained data regarding FNH-like nodules were then correlated with other pathological findings and with clinical data obtained during pretransplant evaluation and recorded in a database. RESULTS: FNH-like nodules were present in 15% of patients and their small size (75% of cases < 1 cm) appears to preclude detection by imaging in almost all cases. The presence of esophageal varices and pretransplant treatment with chemoembolization were independently and significantly associated with the presence of FNH-like nodules. There were no associations between FNH-like nodules on the one hand and low-grade dysplastic nodules, high-grade dysplastic nodules, and HCCs on the other hand. CONCLUSIONS: The clinicopathological features of FNH-like nodules support the hypothesis that vascular alterations in liver cirrhosis play an important role in their pathogenesis and that FNH-like nodules do not have an increased risk of malignant transformation.

Implementation of an intervention plan designed to optimize donor referral in a donor hospital network.

CONTEXT: The shortage of donor organs remains the most important factor of waiting list mortality in organ transplantation worldwide. Donor detection is influenced by the legal system, family refusal, and underreporting caused by erroneous knowledge of donation criteria and lack of familiarity with the procedure. OBJECTIVE: To identify possible key factors of donor referral patterns within an existing cooperation with donor hospitals and donor units across the Dutch-speaking part of Belgium, an area of approximately 3 million inhabitants. An intervention plan to optimize the cooperation and procedure quality and efficiency was designed. DESIGN: The intervention plan was based on 3 essential principles in donor referral by donor reporters, information on donor criteria, facilitation of the donor procedure, and communication between donor reporters and the transplant center. The interventions were structured to optimize all 3 of these principles. Two successive periods of 4 years were retrospectively compared. PARTICIPANTS: Data were collected retrospectively on donor referral behavior from a total of 37 donor hospitals and donor units over an 8-year period. MAIN OUTCOME MEASURES: The referrals were reviewed for potential donors, effective donors, percentage of effective donors, refusal rate of relatives, number of tissue donors, impact on local and national transplant programs, and national donor numbers. RESULTS: Data showed a significant positive impact on donor referrals and donor referral behavior (+27% potential donors, +30% effective donors, +172.7% tissue donors, -7% family refusals rates, +9.63% national donors). The results stress the importance of reduced workload and optimization of communication and information availability in an existing donor hospital network.