1.
Antiviral Res
; 7(1): 35-42, 1987 Jan.
Article
in English
| MEDLINE
| ID: mdl-3026245
ABSTRACT
In poliovirus-infected cells, the viral protein and RNA synthesis were severely reduced, provided 3-methylquercetin was present between 1 and 2 h post-infection. Under these conditions, the virally induced host shut-off remained in effect. On the other hand, in uninfected HeLa cells, protein and RNA synthesis was inhibited only slightly by 3-methylquercetin. The inhibition of poliovirus cytopathogenicity in Vero cells by 3-methylquercetin exhibited a similar time dependence.
Subject(s)
Flavonoids/pharmacology , Flavonols , Poliovirus/drug effects , Protein Biosynthesis , Quercetin/pharmacology , RNA, Viral/biosynthesis , Viral Proteins/biosynthesis , Animals , Cytopathogenic Effect, Viral/drug effects , Electrophoresis, Polyacrylamide Gel , HeLa Cells , Humans , Poliovirus/genetics , Poliovirus/metabolism , Quercetin/analogs & derivatives , RNA, Viral/drug effects , Vero Cells
2.
Prog Clin Biol Res
; 213: 537-40, 1986.
Article
in English
| MEDLINE
| ID: mdl-3012584