Electrocardiographic phenotype of exercise-induced arrhythmogenic cardiomyopathy: A retrospective observational study.

Introduction: The right ventricle can be susceptible to pathologic alterations with exercise. This can cause changes to the ECG. Our aim was to identify the electrocardiographic phenotype of exercise induced (ExI) arrhythmogenic cardiomyopathy (ACM). Methods: A retrospective analysis of ECGs at rest, peak exercise and 1 min of recovery in four groups of individuals was performed: Arrhythmogenic Cardiomyopathy with genetic confirmation (Gen-ACM; n = 16), (genetically negative) ExI-ACM (n = 15), control endurance athletes (End; n = 16) and sedentary individuals (Sed; n = 16). The occurrence of ventricular arrhythmias (VA) and, at each stage, QRS duration, Terminal Activation Delay (TAD), the ratio of the sum of the QRS durations in the right precordials (V1-V3) over that in the left precordials (V4-V6; R/L duration ratio), the presence of complete RBBB and T-wave inversion (TWI) beyond lead V2 were evaluated. Results: At rest, complete RBBB was exclusively found in Gen-ACM (6%) and ExI-ACM (13%). No epsilon waves were identified. TWI beyond V2 was uniquely present in Gen-ACM (73%) and ExI-ACM (38%; p < 0.001). VA was present in Gen-ACM (88%); ExI-ACM (80%), End (25%) and Sed (19%; p < 0.001). The presence of R/L duration ratio of >1.2 and TAD ≥ 55 ms were not significantly different over the four groups (p = 0.584 and p = 0.218, respectively). At peak exercise the most striking finding was a significant decrease of the R/L duration ratio in individuals with ACM, which was the result of lateral precordial QRS prolongation. Conclusion: ExI-ACM shares important ECG-features with Gen-ACM, suggesting a similar underlying pathogenesis regardless of the presence or absence of desmosomal mutations.

Giant left circumflex coronary artery aneurysm with fistula to the right atrium.

Coronary artery fistulae are rare cardiac anomalies with a prevalence of 0.2% of all the patients undergoing coronary angiography. The majority of them are congenital and generally origin from the right coronary artery. Occasionally acquired (mostly iatrogenic) fistulae can develop. Although frequently subclinical, symptoms of angina and congestive heart failure may occur. We present an unusual well-illustrated case of a strongly dilated circumflex coronary artery with formation of two giant aneurysms and fistulous communication towards the right atrium.

Debulking of stage IVA thymoma.

We present a debulking procedure for the removal of a stage IVA thymoma in a patient with myasthenia gravis (MG). This included thymectomy to remove the primary thymoma, resection of an anterior paracardial mass, a posterior pleural mass, partial pleurectomy, resection of phrenic nerve and wedge excisions of the right upper, middle and lower lobes.

Prognostic factors and genetic markers in thymoma.

In this literature review prognostic factors and genetic markers that play a role in the staging of thymomas are discussed. The effect on prognosis of different factors, such as paraneoplastic syndromes, age, gender, classification, capsular invasion and surgical treatment, is evaluated. There is no generally accepted pathological classification of thymomas. More recently developed surgical techniques such as video-assisted or robotic thoracic surgery require longer follow-up times to determine whether they have equal long-term results compared to the classical surgical techniques. Many genetic markers have been described but at the present time no definite guidelines can be provided regarding screening and staging of thymomas.