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Bioorg Med Chem Lett
; 15(3): 497-500, 2005 Feb 01.
Article
in English
| MEDLINE
| ID: mdl-15729771
ABSTRACT
We describe the synthesis and SAR of a new class of CCR2 antagonists based on 2-mercaptoimidazole scaffold. The initial lead 1a was optimized to the 3,4-disubstituted analogues 1p-(S) and 1q-(S), which have IC(50) values in the MCP-1 induced Ca-flux below 0.01 microM.
