ABSTRACT
During the last 25 years, the clinical and experimental activity in nuclear medicine at Erasme hospital has been influenced by the implementation of positron emission tomography (PET) in 1990 as a method of brain functional investigation. The activity of the PET/biomedical cyclotron unit has been dedicated to various subjects in neurology, neurosciences, psychiatry, oncology and cardiology. This has been made possible by developments in radiochemistry. The radiochemistry laboratory has designed and produced original tracers such as 9-[(3-[18F]fluoro-1-hydroxy-2-propoxy)-methyl]guanine (FHPG), a tracer of viral thymidine kinase activity in gene therapy protocols. We have brought new applications of PET, such as its integration into stereotactic neurosurgical and radioneurosurgical techniques in order to improve their diagnostic and therapeutic performance in neurooncology. We have also conducted multiple studies on brain physiology and pathophysiology, in particular with the use of functional and metabolic brain mapping methods and the use of tracers of neurotransmission systems. The Department of nuclear medicine has also performed studies on bone metabolism and investigated in vivo imaging methods of infectious and immune processes.
Subject(s)
Nuclear Medicine Department, Hospital , Belgium , Biomedical Research , Cyclotrons , Hospitals, University , Humans , Tomography, Emission-ComputedABSTRACT
Patients with pure cerebellar cortical atrophy (CCA) present isolated cerebellar signs, whereas patients with sporadic olivopontocerebellar atrophy (sOPCA) present various combinations of cerebellar and extracerebellar signs. However, the differential diagnosis between these two forms of cerebellar degeneration is often a challenge for the clinician. Therefore, any test helping in this differential diagnosis might have a potential clinical interest. In this study, our goal was to investigate the adaptation to increased inertia in patients with sOPCA exhibiting combined cerebellar and pyramidal signs, during the performance of fast wrist flexions. We found that these patients exhibited a hypermetria which remained unchanged after addition of inertia, because they were unable to increase neither their agonist activity (launching force), nor their antagonist activity (braking force). This contrasts with our previous findings in patients with CCA. In these latter, the hypermetria worsened when the inertial load of the hand increased because those patients were able to increase their agonist activity, but not their antagonist activity. The adaptation to inertia might thus help to differentiate CCA and sOPCA.
Subject(s)
Joints/physiopathology , Movement/physiology , Olivopontocerebellar Atrophies/physiopathology , Adult , Aged , Cerebellar Diseases/physiopathology , Electromyography , Female , Hand/physiology , Humans , Magnetic Resonance Imaging , Male , Middle Aged , Muscle, Skeletal/physiopathology , Pyramidal Tracts/physiopathologyABSTRACT
An automatic system allowing repetitive bolus injection of oxygen-15-labeled water for PET studies is described in this report. The production of this radiopharmaceutical by the 16O(p,pn)15O nuclear reaction on H2(16O), its purification and delivery nearby the PET camera, the injection system, and the quality controls are presented.
