ABSTRACT
We studied the sensitivity for Toxocara Canis (ELISA technique) in 5 cases of retinoblastoma confirmed by anatomopathological examination. Some presented with a positive reaction in serum and/or in aqueous. Now that surgical technique are available that permit to functionally save eyes affected by toxocariasis, we felt that a safe and reliable differential diagnosis between toxocariasis and retinoblastoma is of major importance. A positive ELISA test even in the aqueous fluid does'nt seem reliable enough for that purpose. We concluded to the necessity to include in preoperative tests some more invasive techniques such as aqueous tap for dosage of lactico-dehydrogenases or vitreous biopsy for cytological examination, at least for the most difficult cases with a positive ELISA test.
Subject(s)
Eye Diseases/diagnosis , Eye Neoplasms/diagnosis , Larva Migrans, Visceral/diagnosis , Retinoblastoma/diagnosis , Aqueous Humor/enzymology , Aqueous Humor/immunology , Child, Preschool , Clinical Enzyme Tests , Diagnosis, Differential , Enzyme-Linked Immunosorbent Assay , Eye Neoplasms/pathology , Female , Humans , Infant , L-Lactate Dehydrogenase/analysis , Male , Retinoblastoma/pathology , Vitreous Body/pathologyABSTRACT
Iris angiography and photofluorometry of the aqueous were performed on 44 normal subjects equally distributed between 15 and 65 years of age. Hemoglobin AIc determinations were performed in 20 of these persons. Leakage from the pupillary margin was present in 20% of the eyes studied. In all cases of leakage, the dye faded quickly after the initial peak concentration. No leakage was observed from radial iris vessels. Photofluorometric readings of the aqueous 60 minutes after injection increased significantly with age. Hemoglobin AIc measurements were observed to correlate significantly with aqueous fluorescein concentration. Both these observations may reflect an altered permeability of biologic membranes associated with aging.
