Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Colon/drug effects , Colonic Diseases/chemically induced , Diclofenac/adverse effects , Intestinal Mucosa/drug effects , Ulcer/chemically induced , Aged, 80 and over , Colon/diagnostic imaging , Colon/pathology , Colonic Diseases/diagnosis , Colonic Diseases/drug therapy , Colonoscopy , Female , Ferric Compounds/therapeutic use , Humans , Intestinal Mucosa/diagnostic imaging , Intestinal Mucosa/pathology , Maltose/analogs & derivatives , Maltose/therapeutic use , Proton Pump Inhibitors/therapeutic use , Tomography, X-Ray Computed , Treatment Outcome , Ulcer/diagnosis , Ulcer/drug therapySubject(s)
Cholestasis, Extrahepatic/etiology , Common Bile Duct , Diverticulum/complications , Duodenal Diseases/complications , Aged, 80 and over , Cholangiopancreatography, Magnetic Resonance , Cholestasis, Extrahepatic/diagnostic imaging , Cholestasis, Extrahepatic/therapy , Common Bile Duct/diagnostic imaging , Conservative Treatment , Diverticulum/diagnostic imaging , Diverticulum/therapy , Duodenal Diseases/diagnostic imaging , Duodenal Diseases/therapy , Female , Humans , Tomography, X-Ray Computed , Treatment OutcomeSubject(s)
Device Removal/methods , Equipment Failure , Gastroplasty/instrumentation , Gastroscopy/methods , Laparoscopy , Silicones , HumansABSTRACT
BACKGROUND AND OBJECTIVES: Faecal calprotectin is a valuable noninvasive marker for inflammatory bowel disease (IBD). The aim of our study was to determine the correlation between six different calprotectin assays and compare their performance for diagnosis and follow up of IBD. METHODS: Thirty-one patients with suspected IBD and 31 patients in follow up were included. We determined calprotectin by means of three rapid immmunochromatographic tests, two enzyme-linked immunosorbent assays, and one automated fluoroimmunoassay. Results were correlated with endoscopic and histological findings. RESULTS: Although all methods correlated significantly, slopes and intercepts differed extensively, with up to 5-fold quantitative differences between assays. Sensitivity and specificity for diagnosis of IBD were 82-83 and 84-89%, respectively. For follow up, sensitivity in detecting mild ulcerative colitis was 71-100%. In moderate-to-severe ulcerative colitis, sensitivity was 100% for all assays. Specificity was 67-86% in both subgroups. In Crohn's disease, only moderate-to-severe disease could be differentiated from remission, with sensitivity 83-86% and specificity 75% for all tests. CONCLUSIONS: All calprotectin assays showed comparable clinical performance for diagnosis of IBD. For follow up, performance was acceptable, except for mild Crohn's disease. Because of the large quantitative differences, further efforts are needed to standardize calprotectin assays.
ABSTRACT
CMV colitis in an immunocompetent host is a rare occurrence. We report a case of CMV colitis after biliopancreatic diversion surgery. The diagnosis of primary CMV infection with CMV colitis was based on histological examination of tissues biopsies obtained at colonoscopy, serology positive for CMV-IgM and CMV-IgG antibodies and a good response to systemic gancyclovir treatment. Malnutrition and colonic mucosal damage, both consequences of biliopancreatic diversion surgery, were thought to be predisposing factors. To our knowledge this is the first report in the English language literature of an association between CMV colitis and status following biliopancreatic diversion surgery.
